Effect of zinc-chelating dipeptides on osteoblastic MC3T3-E1 cells: Activation of aminoacyl-tRNA synthetase

Yamaguchi, Masayoshi; Kishi, Seiko; Hashizume, Masayuki

doi:10.1016/0196-9781(94)90110-4

Cited by 68 publications

(45 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result suggests that the combination of genistein and zinc stimulates the transcriptional process in osteoblastic cells. Genistein or zinc has a stimulatory effect on protein synthesis at the transcriptional process (8,13,16). Presumably, the combination of genistein and zinc stimulates both transcriptional and translational activities in osteoblastic cells.…”

Section: Discussionmentioning

confidence: 99%

“…Genistein or zinc has been shown to activate aminoacyl-tRNA synthase, the rate-limiting enzyme of translational protein synthesis, and to stimulate protein synthesis in osteoblastic MC3T3-E1 cells (8,13,16). The cellular mechanism by which the combination of genistein and zinc has an anabolic effect on bone components in rats has not been determined.…”

Section: Discussionmentioning

confidence: 99%

“…This effect may involve the activation of aminoacyltRNA synthase by genistein and zinc, since these factors can increases the enzyme activity in the cytosol of osteoblastic cells in vitro (8,15,16).…”

Section: Discussionmentioning

confidence: 99%

“…Zinc can stimulate protein synthesis in osteoblastic cells in vitro by activating aminoacyl-tRNA synthetase (16). The oral administration of a zinc compound prevented bone loss in an animal model of osteoporosis (17).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Genistein and zinc synergistically enhance gene expression and mineralization in osteoblastic MC3T3-E1 cells

Uchiyama

Yamaguchi²

2007

Int J Mol Med

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genistein and zinc synergistically enhance gene expression and mineralization in osteoblastic MC3T3-E1 cells

Uchiyama

Yamaguchi²

2007

Int J Mol Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…The last full review (66) about the dietary phytoestrogens and their effect on bone justifies the bone-conserving properties of isoflavones by the following bodies of experimental evidences showing tight similarities with an experimental pharmacological model from in vitro studies of cultured bone cells through animal models of osteoporosis to epidemiological and intervention studies on humans. Most of the in vitro studies with human and animal osteoblasts and osteoblast-like cell-lines have shown that daidzein and genistein have a stimulatory effect on protein synthesis and on alkaline phosphatase release (67,68). This effect is blocked by the addition of actinomycin or cycloheximide, suggesting that these isoflavones influence transcriptional or translational events (66).…”

Section: A Pharmacological Model: Phytoestrogens and Bone Healthmentioning

confidence: 99%

Phytoestrogens: Food or Drug?

Bacciottini¹,

Falchetti²,

Pampaloni³

et al. 2006

Postmenopausal Osteoporosis

View full text Add to dashboard Cite

SummaryWithin the past several years, the relation between diet and health has been accepted by the mainstream nutrition community and in this connection interest in the physiological role of bioactive compounds present in plants has dramatically increased over the last decade. The phytoestrogens are bioactive molecules present as nutritional constituents of widely consumed vegetables. Their name derives from the fact that they are able to bind to estrogen receptors and to induce an estrogenic/antiestrogenic response in target tissues. Natural estrogens are involved in a multiplicity of programmed events in target tissues as uterus, breast, pituitary gland and hormone responsive tumors. Phytoestrogens are present in many human foodstuffs including fruits (plum, pear, apple grape berries, …), vegetables (beans, sprouts, cabbage, spinach, soybeans, grains, hops, garlic, onion,…), wine, tea, and they have been identified in a number of botanical dietary supplements. They include a wide variety of structurally different compounds such as isoflavones, mainly found in soy, lignans found in grains, stilbenes found in the skin of grapes. Other less investigated compounds include flavones, flavans, isoflavanes and coumestans. The estrogenic or antiestrogenic activity of any chemicals depends on the ability of the compound to interact with the ERs (ERα α, ERβ β). This article reported the knowledge about the activity of phytoestrogens from a pharmacological point of view for their estrogenicity or antiestrogenicity.

show abstract