Effect of zinc on hyperammonemia in sickle cell anemia subjects

Prasad, Ananda S.; Rabbani, Parviz; Warth, James A.

doi:10.1002/ajh.2830070404

Cited by 28 publications

(15 citation statements)

References 8 publications

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“…Zinc deficiency is relatively common in adults with SCD, affecting about 60%-70% of adult subjects in our center [23][24][25]. In SCD patients, our diagnosis of zinc deficiency is based on zinc levels in lymphocytes and granulocytes [12,20,[23][24][25].…”

Section: Studies In Persons With Scdmentioning

confidence: 99%

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Effects of Zinc Deficiency on Th1 and Th2 Cytokine Shifts

2000

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Nutritional deficiency of zinc is widespread throughout developing countries, and zinc-deficient persons have increased susceptibility to a variety of pathogens. Zinc deficiency in an experimental human model caused an imbalance between Th1 and Th2 functions. Production of interferon-gamma and interleukin (IL)-2 (products of Th1) were decreased, whereas production of IL-4, IL-6, and IL-10 (products of Th2) were not affected during zinc deficiency. Zinc deficiency decreased natural killer cell lytic activity and percentage of precursors of cytolytic T cells. In HuT-78, a Th0 cell line, zinc deficiency decreased gene expression of thymidine kinase, delayed cell cycle, and decreased cell growth. Gene expression of IL-2 and IL-2 receptors (both alpha and beta) and binding of NF-kappaB to DNA were decreased by zinc deficiency in HuT-78. Decreased production of IL-2 in zinc deficiency may be due to decreased activation of NF-kappaB and subsequent decreased gene expression of IL-2 and IL-2 receptors.

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Section: Studies In Persons With Scdmentioning

confidence: 99%

“…In SCD patients, our diagnosis of zinc deficiency is based on zinc levels in lymphocytes and granulocytes [12,20,[23][24][25]. Increased hemolysis in SCD patients releases a considerable amount of zinc, which circulates in the plasma pool.…”

Section: Studies In Persons With Scdmentioning

confidence: 99%

Effects of Zinc Deficiency on Th1 and Th2 Cytokine Shifts

2000

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“…We have previously shown that growth delays, hypogonadism in males, abnormal dark adaptation and hyperammonemia in SCD patients were related to zinc deficiency and corrected by zinc supplementation [24,[32][33][34]. I will now summarize our studies related to immune functions in SCD.…”

Section: Studies In Patients With Sickle Cell Disease (Scd)mentioning

confidence: 93%

“…Zinc deficiency is common in adult sickle cell disease (SCD) patients, affecting approximately 60-70% of adult subjects in our center [23][24][25]. Diagnosis of zinc deficiency in our laboratory is based on zinc levels in lymphocytes and granulocytes in SCD patients [12,20,[23][24][25].…”

Section: Studies In Patients With Sickle Cell Disease (Scd)mentioning

confidence: 99%

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Effects of zinc deficiency on immune functions

Prasad

2000

J. Trace Elem. Exp. Med.

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Effect of zinc supplementation on incidence of infections and hospital admissions in sickle cell disease (SCD)

et al. 1999

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Zinc deficiency is a common nutritional problem in adult sickle-cell disease (SCD) patients. Hyperzincuria and increased requirement of zinc due to continued hemolysis in SCD are probable bases for zinc deficiency in these patients. Zinc deficiency affects adversely T-helper 1 (TH 1) functions and cell mediated immunity and interleukin (IL)-2 production is decreased in zinc deficient subjects. We hypothesized that zinc supple-mentation will improve T-helper 1 function and decrease incidence of infections in patients with SCD. We tested this hypothesis in 32 SCD subjects who were divided in three groups (Grs A, B, and C). Grs A (n = 11) and B (n = 10) were zinc deficient based on cellular zinc criteria and Gr C (n = 11) were zinc sufficient. Gr A subjects were observed for 1 year (baseline), following which they received zinc acetate (50 to 75 mg of elemental zinc orally daily) for 3 years. Gr B subjects were observed for 1 year (baseline), following which they received placebo for 1 year and then switched to zinc supplementation (50 to 75 mg of elemental zinc orally daily) for 2 years. Gr C subjects did not receive any intervention inasmuch as they were zinc sufficient. Prolonged zinc supplementation resulted in an increase in lymphocyte and granulocyte zinc (P = 0.0001), and an increase in interleukin-2 production (P = 0.0001), decreased incidence of documented bacteriologically positive infections (P = 0.0026), decreased number of hospitalizations and decreased number of vaso-occlusive pain crisis (P = 0.0001). The predominant pathogens isolated were staphylococci and streptococci involving the respiratory tract and aerobic gram-negative bacteria , particularly Escherichia coli, involving the urinary tract. Further confirmation of our observations will require prospective studies of zinc supplementation in a larger number of SCD patients. Am.

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Effect of zinc on hyperammonemia in sickle cell anemia subjects

Cited by 28 publications

References 8 publications

Effects of Zinc Deficiency on Th1 and Th2 Cytokine Shifts

Effects of Zinc Deficiency on Th1 and Th2 Cytokine Shifts

Effects of zinc deficiency on immune functions

Effect of zinc supplementation on incidence of infections and hospital admissions in sickle cell disease (SCD)

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