Effect of zinc on the lipid peroxidation and the antioxidant defense systems of the alloxan-induced diabetic rabbits

Düzgüner, Vesile; Kaya, Şule

doi:10.1016/j.freeradbiomed.2007.02.021

Cited by 69 publications

(53 citation statements)

References 52 publications

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“…Our results show decreased activities of heart antioxidant enzymes catalase (CAT) and increased TBARS level in diabetic rats compared with the normal controls. These results are in concordance with other findings showing that hyperglycaemia is usually combined with oxidative stress establishment [19]. All these antioxidant system depletions were restored by the administration of Oleuropein at 16 mg/kg b. w a long of four weeks.…”

Section: Discussionsupporting

confidence: 93%

Heart Histopathology and Oxidative Features in Diabetic Rats and Protective Effects of Oleuropein

Jemai¹,

Sayadi²

2015

ABB

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Diabetes induced cardiac dysfunction and lesions are nowadays confirmed. In fact, Diabetes is a chronic metabolic disease, which is associated with oxidative stress and hyperglycaemia which have direct toxic effects on cardio-myocytes. Olive leaves extract compounds, such as Oleuropein, have been used in many therapeutic and preventive cases. The present study is designed to evaluate the effect of Oleuropein as antioxidant on the heart histological and oxidative features in diabetic rats. Diabetes was induced by alloxan at 180 mg/kg b.w by intra-peritoneal method once. Four weeks Oleuropein rich olive leaves administration restore significantly the heart histological alteration established by diabetes and enhanced the cardiac antioxidant potential.

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Section: Discussionsupporting

confidence: 93%

Heart Histopathology and Oxidative Features in Diabetic Rats and Protective Effects of Oleuropein

Jemai¹,

Sayadi²

2015

ABB

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“…The hyperglycemia also induces the elevation of the plasma levels of urea and creatinine, which are considered as significant markers of renal dysfunction, and all theses changes decrease the body, kidney and liver weights of animals. These findings are in agreement with Igarashi et al (19) and Duzguner and Sule Kaya (20) who reported that alloxan induced inhibition of SOD and CAT activities and increased cholesterol, triglyceride, lipid peroxidation and hepatic and renal indices of toxicity in diabetic animals.…”

Section: Discussionsupporting

confidence: 92%

1α,25 Dihydroxyvitamin D3: Therapeutic and Preventive Effects against Oxidative Stress, Hepatic, Pancreatic and Renal Injury in Alloxan-Induced Diabetes in Rats

Hamden

Carreau

Jamoussi

et al. 2009

J Nutr Sci Vitaminol

119

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Summary Diabetes mellitus is a major endocrine disorder and a growing health problem in most countries which can be ameliorated by numerous bio-molecules such as 1 ␣ ,25 dihydroxyvitamin D3 [1 ␣ ,25(OH)2VD3]. With this in mind, the current study investigated the therapeutic and preventive effects of 1 ␣ ,25(OH)2VD3 on diabetes and its side effects: toxicity in liver, pancreas and kidneys. Our results show that administration of 1 ␣ ,25(OH)2VD3 in diabetic rats increased the plasmatic insulin level, favored the normal blood glucose levels and normalized the hepatic glycogen concentration. In addition, 1 ␣ ,25(OH)2VD3 enhanced superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) (by 207, 52 and 72%, respectively) compared to diabetic rats. It also reduced lipid peroxidation and the indices of toxicity in liver and kidneys by significantly decreasing alkaline phosphatases (PAL), aspartate and lactate transaminase (AST and ALT) activities, total and direct bilirubin, triglycerides (TG), cholesterol, creatinine, urea and iron levels in diabetic rats. Moreover, the plasmatic non-enzymatic antioxidant level of HDL-cholesterol, magnesium (Mg), calcium (Ca) and copper (Cu) increased after 1 ␣ ,25(OH)2VD3 administration. The administration of 1 ␣ ,25(OH)2VD3 in diabetic rats protects against alloxan-induced histological changes in pancreas. Conclusion: from these data, it is concluded that 1 ␣ ,25(OH)2VD3 might be useful for the therapy and prevention of diabetes and the numerous side effects especially toxicity in liver, pancreas and kidneys and this protective effect is more obvious in our preventive experiment.

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“…Although, diabetes-related complications, which cause death, are vascular complications (Afridi et al 2008). It has been shown that in the various tissues of diabetic rats there were increased lipid peroxidation and altered antioxidant enzymes (Sekeroglu et al 2000;Duzguner and Kaya 2007;Jin et al 2008). In this study, results showed that diabetic rats showed improved oxidative stress by enhanced lipid peroxidation and antioxidant enzymes activities.…”

Section: Discussionmentioning

confidence: 51%

Lead Nitrate Induced Testicular Toxicity in Diabetic and Non-Diabetic Rats: Protective Role of Sodium Selenite

Apaydın

Kalender

Baş

et al. 2014

Braz. arch. biol. technol.

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Effect of zinc on the lipid peroxidation and the antioxidant defense systems of the alloxan-induced diabetic rabbits

Cited by 69 publications

References 52 publications

Heart Histopathology and Oxidative Features in Diabetic Rats and Protective Effects of Oleuropein

Heart Histopathology and Oxidative Features in Diabetic Rats and Protective Effects of Oleuropein

1α,25 Dihydroxyvitamin D3: Therapeutic and Preventive Effects against Oxidative Stress, Hepatic, Pancreatic and Renal Injury in Alloxan-Induced Diabetes in Rats

Lead Nitrate Induced Testicular Toxicity in Diabetic and Non-Diabetic Rats: Protective Role of Sodium Selenite

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