Effect of zinc oxide nanoparticles incorporated into tissue conditioner on antifungal, physical, and mechanical properties

Abstract

This study evaluated the antifungal, physical, and mechanical properties of tissue conditioner incorporated with different amounts of zinc oxide nanoparticles (ZnOnps) at different storage times (0, 7, and 14 days). Specimens of 0, 5, 10, 15 wt% ZnOnps, or 15 wt% nystatin incorporated into tissue conditioner were fabricated (control, 5Zn, 10Zn, 15Zn, and Nys). The direct contact test (n=6) was performed to evaluate the antifungal effect against C. albicans suspension. The penetration depth (n=6) and tensile bond strength (n=8) were evaluated following ISO 13139. The 15Zn significantly reduced C. albicans cell number compared with control at all storage times (p<0.001). The penetration depths and tensile bond strengths of the 5Zn, 10Zn, 15Zn, and Nys were not significantly different compared with control at all storage times (p>0.05). In conclusion, the 15Zn provides antifungal effect up to 14 days without adverse effects on penetration depth and tensile bond strength.

Therapeutic Role of Nystatin Added to Tissue Conditioners for Treating Denture-Induced Stomatitis: A Systematic Review

“…Following the title screening, 35 abstracts were selected. A thorough screening of the abstracts resulted in total of 26 articles [30,40,41,43,45,47,48,[53][54][55][56][57][58][63][64][65][66][67][68][69][70][71][72][73][74][75]. Furthermore, nine articles [29,38,42,44,46,51,52,76,77] were added as a result of manual search, making a total of 35 articles for full text evaluations ( Figure 1).…”

“…Furthermore, nine articles [29,38,42,44,46,51,52,76,77] were added as a result of manual search, making a total of 35 articles for full text evaluations ( Figure 1). The reading of the 35 full-text articles permitted the selection of 25 studies (one animal study [47], three clinical studies [38,41,51], and 21 in-vitro studies [29,40,[42][43][44][45][46][52][53][54][55][56][57][58]63,66,70,72,[74][75][76]) meeting the inclusion criteria of this systematic review, and 10 articles were excluded ( Table 1). A meta-analysis (quantitative analysis) was not possible due to the high heterogeneity between the data of the included studies; therefore, only a qualitative analysis was performed.…”

“…Out of 25 papers, one was an animal study [47], three were clinical studies [38,41,51], and the remaining 21 were in-vitro studies [29,40,[42][43][44][45][46][52][53][54][55][56][57][58]63,66,70,72,[74][75][76].…”

“…Different TCs were used in various studies ( Table 2). The most commonly used TC was Viscogel [40][41][42][43]46,51,66,76] and Trusoft and Softone [45,47,[54][55][56][57]70,72,74], followed by GC soft liner [43,44,58], Lynal [52,66], Fitt [40], Dura conditioner [53], Acrosoft [29], Coe comfort [63], Coe soft [40], and Silagum-Comfort [75]. However, one study did not report the TC [38].…”

“…Nonetheless, there are associated unwanted effects, such as a bitter taste, nausea, mucosal irritation, and poor acceptance by patients [50]. Different studies have investigated the modified TCs with nystatin associated with efficacy [40,41,46,51], drug delivery [38,42], dimensional alterations and stability [52][53][54][55][56][57][58], and the stability and time period of the antifungal actions [44]. While there are plenty of studies published, the impact of nystatin in addition to TCs to treat DIS is still not conclusive.…”