Effect of zinc substitution in hydroxyapatite coating on osteoblast and osteoclast differentiation under osteoblast/osteoclast co-culture

Meng, Guolong; Yao, Ruijuan; He, Jing; Wu, Yao; Wu, Fang

doi:10.1093/rb/rbz001

Cited by 16 publications

(16 citation statements)

References 28 publications

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“…Chemical elements, such as zinc [ 1 ], magnesium [ 46 ], calcium [ 47 ] and strontium [ 48 ], have been shown to exhibit superior properties for bone regeneration by promoting bone-related cell proliferation, differentiation and osteogenesis-related genes expression [ 49–51 ]. Recently, SR has received more attention owing to its ability to simultaneously modulate osteoclasts and osteoblasts through several pathways [ 28 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

“…The specialized mesenchymal cells, osteoblasts, are crucial for the mineralization of the skeleton and bone mass maintenance; In addition, osteoclasts also play an important role in bone resorption. The faults of osteoblast and osteoclast function are a major cause of terrible bone density [ 1 ], as it is seen in osteoporosis (OP), which is characterized by the loss of bone mass and an increased risk of fractures [ 2 , 3 ]. With an aging population in China, the morbidity rate of osteoporotic fracture has increased [ 4 , 5 ], increasing the need for implant materials.…”

Section: Introductionmentioning

confidence: 99%

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Strontium ranelate incorporated 3D porous sulfonated PEEK simulating MC3T3-E1 cell differentiation

Sun

Liu

Tan

et al. 2020

Regenerative Biomaterials

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Polyetheretherketone (PEEK) has been used as an implant material because it has similar mechanical properties to natural bone. However, inferior osseointegration and bioinertness hamper the clinical application of PEEK. In this study, the surfaces of sulfonated three-dimensional (3D) PEEK porous structures were loaded with different concentrations of strontium ranelate, a compound commonly used in the treatment or prevention of osteoporosis by promoting bone formation and inhibiting bone resorption. Field-emission scanning electron microscopy was used to characterize the topography of the structures, elemental carbon, oxygen and strontium contents were measured by X-ray photoelectron spectroscopy, and surface zeta potentials and water-contact angle were also measured. The results indicated that strontium ranelate was successfully loaded onto the 3D porous structures. In vitro cellular results showed that strontium ranelate-treated sulfonated PEEK (SP-SR) strengthened the adhesion of MC3T3-E1 cells. The activity of alkaline phosphatase, collagen secretion and extracellular matrix mineralization deposition of MC3T3-E1 cells were also improved on the surface of SP-SR. These results indicate that SP-SR could serve a new implant candidate for surgical treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Strontium ranelate incorporated 3D porous sulfonated PEEK simulating MC3T3-E1 cell differentiation

Sun

Liu

Tan

et al. 2020

Regenerative Biomaterials

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“…Meng et al [101] deposited zinc-substituted HA coating on the Ti-6Al-4V alloy substrates by liquid precursor plasma spraying technique. The zinc-substituted HA coating showed moderate effect on the promotion of osteogenic differentiation of BMDSCs and the ability to hinder osteoclastic activity of osteoclast-like cell precursor cells (RAW 264.7 cell line) at early stages of co-culture condition.…”

Section: Peekmentioning

confidence: 99%

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Kazimierczak

Przekora

2020

Coatings

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The main aim of bone tissue engineering is to fabricate highly biocompatible, osteoconductive and/or osteoinductive biomaterials for tissue regeneration. Bone implants should support bone growth at the implantation site via promotion of osteoblast adhesion, proliferation, and formation of bone extracellular matrix. Moreover, a very desired feature of biomaterials for clinical applications is their osteoinductivity, which means the ability of the material to induce osteogenic differentiation of mesenchymal stem cells toward bone-building cells (osteoblasts). Nevertheless, the development of completely biocompatible biomaterials with appropriate physicochemical and mechanical properties poses a great challenge for the researchers. Thus, the current trend in the engineering of biomaterials focuses on the surface modifications to improve biological properties of bone implants. This review presents the most recent findings concerning surface modifications of biomaterials to improve their osteoconductivity and osteoinductivity. The article describes two types of surface modifications: (1) Additive and (2) subtractive, indicating biological effects of the resultant surfaces in vitro and/or in vivo. The review article summarizes known additive modifications, such as plasma treatment, magnetron sputtering, and preparation of inorganic, organic, and composite coatings on the implants. It also presents some common subtractive processes applied for surface modifications of the biomaterials (i.e., acid etching, sand blasting, grit blasting, sand-blasted large-grit acid etched (SLA), anodizing, and laser methods). In summary, the article is an excellent compendium on the surface modifications and development of advanced osteoconductive and/or osteoinductive coatings on biomaterials for bone regeneration.

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“…Accordingly, several studies reported that the size of HAp nuclei in Zn 2+ -containing glass is more significant than that of Zn 2+ -free glass because each (few) HA nucleation sites had a better chance of absorbing Ca 2+ and PO 4 3- in SBF [ 55 , 56 ]. On the other hand, Silicium increases the electronegative surface and is a suitable microstructure for nucleation and apatite formation sites [ 57 , 58 ]. In our report here, as the soaking time increased to 21 days, the composite surface was gradually covered by a layer of HAp, and the diffusion of Zn 2+ from the composite into the solution became more complex than the diffusion of calcium due to the higher Zn-O bond energy (180 kJ/mol) compared with the Ca-O bond (110 kJ/mol).…”

Section: Discussionmentioning

confidence: 99%

Regeneration of Bone Defects in a Rabbit Femoral Osteonecrosis Model Using 3D-Printed Poly (Epsilon-Caprolactone)/Nanoparticulate Willemite Composite Scaffolds

Bardeei

Seyedjafari

Hossein

et al. 2021

IJMS

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Steroid-associated osteonecrosis (SAON) is a chronic disease that leads to the destruction and collapse of bone near the joint that is subjected to weight bearing, ultimately resulting in a loss of hip and knee function. Zn2+ ions, as an essential trace element, have functional roles in improving the immunophysiological cellular environment, accelerating bone regeneration, and inhibiting biofilm formation. In this study, we reconstruct SAON lesions with a three-dimensional (3D)-a printed composite made of poly (epsilon-caprolactone) (PCL) and nanoparticulate Willemite (npW). Rabbit bone marrow stem cells were used to evaluate the cytocompatibility and osteogenic differentiation capability of the PCL/npW composite scaffolds. The 2-month bone regeneration was assessed by a Micro-computed tomography (micro-CT) scan and the expression of bone regeneration proteins by Western blot. Compared with the neat PCL group, PCL/npW scaffolds exhibited significantly increased cytocompatibility and osteogenic activity. This finding reveals a new concept for the design of a 3D-printed PCL/npW composite-based bone substitute for the early treatment of osteonecrosis defects.

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Effect of zinc substitution in hydroxyapatite coating on osteoblast and osteoclast differentiation under osteoblast/osteoclast co-culture

Cited by 16 publications

References 28 publications

Strontium ranelate incorporated 3D porous sulfonated PEEK simulating MC3T3-E1 cell differentiation

Strontium ranelate incorporated 3D porous sulfonated PEEK simulating MC3T3-E1 cell differentiation

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Regeneration of Bone Defects in a Rabbit Femoral Osteonecrosis Model Using 3D-Printed Poly (Epsilon-Caprolactone)/Nanoparticulate Willemite Composite Scaffolds

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