Effect of zinc supplementation on infants with severe pneumonia

Xiao, Yuan; Qian, Suyun; Zheng, Lirong; Zhang, Zhe-Zhe

doi:10.1007/s12519-015-0072-9

Cited by 27 publications

(44 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite the earlier observed reduction of treatment failure risk (94) and case fatality [RR=0.67 (95% cI: 0.24-0.85)] (95) in children with severe pneumonia, a more recent study demonstrated that Zn supplementation in 2-24 months old children with radiologically verified pneumonia did not result in significant improvement of risk reduction of treatment failure (96). Moreover, Zn supplementation in Zn-deficient children with pneumonia until achievement of normal serum Zn levels did not improve clinical appearance of the disease (97).…”

Section: Pediatric Respiratory Infectionsmentioning

confidence: 88%

Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review)

et al. 2020

View full text Add to dashboard Cite

Section: Pediatric Respiratory Infectionsmentioning

confidence: 88%

Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review)

et al. 2020

View full text Add to dashboard Cite

“…Considering the known effects of zinc in regulating the immune system, trials have been conducted to investigate the efficacy of zinc in treating respiratory illnesses ( Table 8 ) [ 253 , 254 , 255 , 256 , 257 , 258 , 259 , 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 ].…”

Section: Zincmentioning

confidence: 99%

“…In a 2018 study, serum zinc levels were found to be significantly lower among pneumonia pediatric patients admitted to PICU compared with patients admitted to other wards; there was a statistically significant decrease in zinc level in critically ill children complicated by sepsis, mechanically ventilated and fatal cases [ 252 ]. Some studies reported similar duration of hospital stay, time to symptoms resolution, and risk of treatment failure in the intervention and in the control group [ 254 , 255 , 256 , 258 , 259 , 262 , 264 , 265 ], while others described partially positive results. Basnet and colleagues [ 260 ] found that zinc recepients recovered slightly faster than controls, although the difference was not statistically significant; Sempertegui et al [ 263 ] evidenced that a higher basal zinc concentration was associated with faster resolution of chest indrawing, although there was no difference in time needed to fully recover nor in the risk of treatment failure; Mahalanbis et al found a reduced duration of ALRI symptoms in boys, but not in girls [ 253 ].…”

Section: Zincmentioning

confidence: 99%

The Role of Micronutrients in Support of the Immune Response against Viral Infections

et al. 2020

View full text Add to dashboard Cite

Viral infections are a leading cause of morbidity and mortality worldwide, and the importance of public health practices including handwashing and vaccinations in reducing their spread is well established. Furthermore, it is well known that proper nutrition can help support optimal immune function, reducing the impact of infections. Several vitamins and trace elements play an important role in supporting the cells of the immune system, thus increasing the resistance to infections. Other nutrients, such as omega-3 fatty acids, help sustain optimal function of the immune system. The main aim of this manuscript is to discuss of the potential role of micronutrients supplementation in supporting immunity, particularly against respiratory virus infections. Literature analysis showed that in vitro and observational studies, and clinical trials, highlight the important role of vitamins A, C, and D, omega-3 fatty acids, and zinc in modulating the immune response. Supplementation with vitamins, omega 3 fatty acids and zinc appears to be a safe and low-cost way to support optimal function of the immune system, with the potential to reduce the risk and consequences of infection, including viral respiratory infections. Supplementation should be in addition to a healthy diet and fall within recommended upper safety limits set by scientific expert bodies. Therefore, implementing an optimal nutrition, with micronutrients and omega-3 fatty acids supplementation, might be a cost-effective, underestimated strategy to help reduce the burden of infectious diseases worldwide, including coronavirus disease 2019 (COVID-19).

show abstract

“…[ 17 ] In children with pneumonia, a common respiratory infectious disease, zinc deficiency is highly prevalent (76.0%), but zinc supplementation seemed to not affect clinical outcomes. [ 18 ] In dengue disease, the role of zinc deficiency in the pathogenesis is still controversial. Yuliana et al .…”

Section: Discussionmentioning

confidence: 99%

A randomized controlled trial of zinc supplementation as adjuvant therapy for dengue viral infection in Thai children

Rerksuppaphol

2018

Int J Prev Med

View full text Add to dashboard Cite

Background:Zinc deficiency is common in developing countries and increases the risk for several infectious diseases. Low serum zinc levels have been reported in children with dengue virus infection (DVI). This study aimed to assess the effects of zinc supplementation on DVI outcomes.Methods:A double-blinded, randomized trial was conducted in 50 children with dengue fever (DF)/dengue hemorrhagic fever admitted to the pediatric unit of MSMC Srinakharinwirot University Hospital, Thailand, between January 2016 and April 2017. Bis-glycinate zinc or placebo was orally administered three times a day for 5 days or until defervescence. The primary outcome was to evaluate the DVI defervescence phase; the secondary outcome was to assess hospitalization length and presence of severe DVI and zinc deficiency.Results:The mean time of defervescence was 29.2 ± 24.0 h in the supplementation group and 38.1 ± 31.5 h in the placebo group (P = 0.270). Meantime of hospital staying was 62.5 ± 23.8 h in the supplementation group and 84.7 ± 34.0 h in placebo group with the mean difference of hospital staying between groups of 22.2 h (95% confidence interval [CI]: 5.5–38.5 h; P = 0.010). Overall prevalence of zinc deficiency was 46%. Serum zinc levels increased from baseline to the end of the study. the mean gain was 26.4 μg/dL (95% CI: 13.6–39.1 μg/dL) in the supplementation group and 14.4 μg/dL (95% CI: 7.4–21.3 μg/dL) in placebo group. No signs of severe DVI were observed in both groups. Zinc supplementation was well tolerated.Conclusions:Overcoming zinc deficiency among Thai children may reduce DF duration and limit the hospitalization, in addition to other advantages that normal serum zinc levels have on overall children health.

show abstract

Effect of zinc supplementation on infants with severe pneumonia

Abstract: Zinc deficiency is common in infants with severe pneumonia. Normalization of zinc levels with zinc supplementation did not improve clinical outcomes of infants with pneumonia.

Cited by 27 publications

References 11 publications

Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review)

Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review)

The Role of Micronutrients in Support of the Immune Response against Viral Infections

A randomized controlled trial of zinc supplementation as adjuvant therapy for dengue viral infection in Thai children

Contact Info

Product

Resources

About