Effect of Zinc Supplementation on Antioxidant Activity in Young Wrestlers

Kara, Ersan; Günay, Mehmet; Cicioğlu, İbrahim; Özal, Mehmet; Kılıç, Mehmet; Moğulkoç, Rasim; Baltacı, Abdülkerim Kasım

doi:10.1007/s12011-009-8457-z

Cited by 38 publications

(30 citation statements)

References 17 publications

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“…This observation is in agreement with the earlier study demonstrating an increase in serum zinc and GPx activity in volunteers obtaining zinc supplementation (Kara et al, 2010). The observed direct correlation between serum selenium level and GPx activity confi rm earlier data (Luoma et al, 1984;Kim et al, 2011).…”

supporting

confidence: 93%

Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

Skalny

Tinkov

Medvedeva

et al. 2015

Acta Sci Pol Technol Aliment

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Background.A signifi cant association between Zn and Se homeostasis exists. At the same time, data on the infl uence of zinc supplementation on selenium distribution in organs and tissues seem to be absent. Therefore, the primary objective of the current study is to investigate the infl uence of zinc asparaginate supplementation on zinc and selenium distribution and serum superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in Wistar rats. Material and methods. 36 rats were used in the experiment. The duration of the experiment was 7 and 14 days in the fi rst and second series, respectively. The rats in Group I were used as the control ones. Animals in Groups II and III daily obtained zinc asparaginate (ZnA) in the doses of 5 and 15 mg/kg weight, respectively. Zinc and selenium content in liver, kidneys, heart, muscle, serum and hair was assessed using inductively coupled plasma mass spectrometry. Serum SOD and GPx activity was analysed spectrophotometrically using Randox kits. Results. Intragastric administration of zinc asparaginate signifi cantly increased liver, kidney, and serum zinc content without affecting skeletal and cardiac muscle levels. Zinc supplementation also stimulated selenium retention in the rats' organs. Moreover, a signifi cant positive correlation between zinc and selenium content was observed. Finally, zinc asparaginate treatment has been shown to modulate serum GPx but not SOD activity. Conclusion. The obtained data indicate that zinc-induced increase in GPx activity may be mediated through modulation of selenium status. However, future studies are required to estimate the exact mechanisms of zinc and selenium interplay.

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supporting

confidence: 93%

Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

Skalny

Tinkov

Medvedeva

et al. 2015

Acta Sci Pol Technol Aliment

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“…Given the mechanisms of immune responses, it can be argued that tissue injury in the skeletal muscle resulting from exercise paves the way for activation of immune reactions (6). However, previous studies indicated that a cytokine response may be observed even after exercise that is not strenuous (7). The decisive factor distinguishing elevation of cytokines in response to the immune response to infections from the post-exercise elevation of cytokines is the increase observed in tumor necrosis factor-α (TNF-α) levels in inflammation.…”

Section: Introductionmentioning

confidence: 99%

Effect of a four-week exercise program on the secretion of IFN-γ, TNF-α, IL-2 and IL-6 cytokines in elite Taekwondo athletes

Kaya

2016

Biomedical Reports

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Abstract. The aim of the present study was to examine how a 4-week exercise program affects the serum levels of certain cytokines in Taekwondo athletes. The study involved 10 elite male Taekwondo athletes (mean age, 20.67±0.24 years; mean weight, 65.45±1.69 kg) who were studying at the Physical Education and Sports High School of Selçuk University (Konya, Turkey) in June 2014. The subjects were involved in a Taekwondo exercise program on every weekday for 4 weeks. The subjects were also engaged in an exercise to exhaustion session twice; once before starting the 4-week exercise program and once upon completion of the program. Blood samples were collected from the subjects in four rounds: During rest, upon fatigue, and before and after the 4-week exercise program. These samples were analyzed to establish the serum levels of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin (IL)-2 and IL-6 using enzyme-linked immunosorbent assay test kits. Pre-and post-exercise program, the IFN-γ and TNF-α levels did not show any significant difference. When compared with the pre-exercise levels, serum IL-2 levels of the subjects were found to be elevated after the 4-week exercise program. The highest serum IL-6 values were established after the subjects were exercised to fatigue before the exercise program was initiated (P<0.05). The 4-week exercise program resulted in a decrease in IL-6 levels (P<0.05). The findings of the study indicate that a 4-week exercise program did not result in significant changes in IFN-γ and TNF-α levels, but led to an increase in IL-2 levels. The notable finding of the present study is that a 4-week exercise program reduces cellular immune functions and, thus, the levels of IL-6, which negatively influences performance.

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“…Введение цинка в организм лаборатор-ных животных, не подверженных ФН, при-водило к статистически значимому повы-шению активности ГПО, что согласуется с полученными ранее данными [9]. Так, в частности, возможный механизм цинк-индуцированного повышения активности ГПО -модуляция уровня селена в организ-ме [12].…”

Section: Influence Of Zinc Administration On Its Tissue Concetration unclassified

Influence of zinc administration on its tissue concetration and activity of serum antioxidant enzymes in rats at physical activity

et al. 2015

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Aim. To investigate the effect of zinc supplementation at physical exercise on the distribution of the metal in the tissues and the activity of serum antioxidant enzymes. Methods. Physical activity was simulated using the treadmill. Laboratory animals were distributed to 6 even (n=12) groups. The first and fourth groups of animals received no zinc-containing additives and were imposed to low and high physical activity, respectively. Animals of the 2 and 3 as well as 5 and 6 groups received 5 and 15 mg/kg/day of zinc asparaginate intragastrically and were imposed to low and high physical activity, respectively. The zinc concentrantion in the organs and tissues was determined by inductively coupled plasma mass spectrometry. The activity of antioxidant enzymes was determined by spectrophotometry. Results. Administration of zinc asparaginate to the laboratory animals with low physical activity resulted in a dose-dependent increase of the metal concentration in liver and kidney parenchyma and blood serum, as well as in increase of serum glutathione peroxidase activity. Intensive physical activity for 14 days was accompanied by a significant increase in serum and kidney tissue zinc level. At the 7-day exposure to zinc at physical activity, a dose-dependent increase in zinc concentration in the organs and increase of serum glutathione peroxidase activity was registered. Zinc administration together with physical activity for 14 days did not result in a significant change in the balance of metal in the body of animals. In contrast to the 7-day exposure, a combination of factors studied for 14 days was accompanied by increased activity of superoxide dismutase, but not glutathione peroxidase. Conclusion. Physical activity of different duration has a significant effect on the zinc kinetics at oral administration, and the activity of serum antioxidant enzymes in laboratory animals.

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Effect of Zinc Supplementation on Antioxidant Activity in Young Wrestlers

Cited by 38 publications

References 17 publications

Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

Effect of a four-week exercise program on the secretion of IFN-γ, TNF-α, IL-2 and IL-6 cytokines in elite Taekwondo athletes

Influence of zinc administration on its tissue concetration and activity of serum antioxidant enzymes in rats at physical activity

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