Effect of zinc supplementation on symptom reduction and length of hospital stay among pediatric patients with Coronavirus disease 2019 (COVID-19)

Alhajjaji, Ghufran Ibrahim; Alotaibi, Nouf H.; Abutaleb, Nada; Alotaibi, Mishal M.; Alhajjaji, Abdulrahman; Alotaibi, Abdulmalik S.; Alshehail, Bashayer; Alotaibi, Moawad E.

doi:10.1016/j.jsps.2023.02.011

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Zinc is widely acknowledged as an essential mineral in the context of COVID-19 infection due to its anti-viral characteristics [188] . Zinc supplementation has been correlated with reduced duration of hospitalization in pediatric patients with COVID-19 [189] . Omega-3 fatty acids have anti-inflammatory and immunomodulatory properties.…”

Section: Management and Essential Medicationsmentioning

confidence: 99%

Unmasking the enigma: An in-depth analysis of COVID-19 impact on the pediatric population

Ahmed,

Tapponi,

Widatallah

et al. 2023

Journal of Infection and Public Health

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Section: Management and Essential Medicationsmentioning

confidence: 99%

Unmasking the enigma: An in-depth analysis of COVID-19 impact on the pediatric population

Ahmed,

Tapponi,

Widatallah

et al. 2023

Journal of Infection and Public Health

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“…Результати іншого дослідження, проведеного також у Туреччині серед хворих на інфекцію COVID-19 віком від 3 місяців до 17 років, свідчать, що середні сироваткові значення таких МіБЕ, як Zn, Cu і селен (Se), є значно нижчими на початку захворювання порівняно з терміном закінчення стаціонарного лікування [5]. Щодо особливостей терапевтичних заходів, то в дітей різного віку застосування Zn-вмісного засобу на тлі інфекції COVID-19 супроводжується суттєвим зменшенням частоти випадків дихальної недостатності, легеневих ускладнень і тривалості госпіталізації [7]. Наразі практично значущим є проведення нових клінічних досліджень для підтвердження доцільності застосування окремих біолементів як складового компонента лікувального комплексу у хворих на інфекцію COVID-19 [14].…”

Section: оригінальні дослідженняunclassified

A linear regression analysis of the effect of bioelements on acute respiratory infections incidence in preschool children

Voloshin,

Marushko,

Savchenko

2023

MPU

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Purpose - to identify the bioelements having the most significant impact on the susceptibility of preschool children to frequent episodes of acute respiratory infections (ARI). Materials and methods. A total of 30 children (14 boys and 16 girls) aged 1-6 years, undergoing inpatient treatment on ARI, were involved in the clinical study. Two integral indicators of acute respiratory infections recurrence, i.e. the infection index and the resistance index, were taken into account for each patient. The children were tested by X-ray fluorescence analysis of 17 bioelements in their hair - Zn, Fe, Cu, Se, Mn, Cr, Co, Br, Ni, Rb, Sr, Sn, Pb, Ca, K, S, and Cl. The statistical processing of the obtained digital material was performed with IBM SPSS Statistics 28 licensed software. A linear regression analysis with stepwise involvement of predictors was applied. Results. In preschool children, there is a moderate negative correlation between hair Rb content and the calculated resistance index (ρ=-0.405; p=0.026; 95% CI: (-0.674)-(-0.042)), according to which lower concentrations of this bioelement are associated with more frequent episodes of ARI. Additionally, Rb has a statistically significant pairwise relationship with several other bioelements studied and the ratios between them. Rb was demonstrated to be directly and most closely correlated with K (ρ=0.842; p<0.001; 95% CI: 0.678-0.926). A prognostic model of the resistance index was obtained, using the linear regression analysis of independent factors. The formula of the prognostic model included only one of the factors studied - the ratio of Mn/Cr content in hair. The informativeness of the mentioned model was 24.9%, which is a quite significant value, taking into consideration a broad range of known predictors for recurrent respiratory infections. Conclusions. The findings are complementary to the available scientific data on the participation of the bioelements in providing resistance to frequent ARI in preschool children. It is planned to continue examining the status of particular bioelements in combination with other potential predictors of recurrent respiratory infections. The study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the local ethics committees of the institutions mentioned in the paper. An informed parental consent was obtained for the study in children. No conflict of interests was declared by the authors.

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Zinc as a potential prophylactic adjuvant therapy for prolonged hospitalization: A systematic review and meta‐analysis of an umbrella of randomized controlled trials

Atef Abdelsattar Ibrahim,

Bendary,

Sabt

et al. 2024

Nut in Clin Prac

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AimsThe present study evaluated the effect of oral zinc supplementation on shortening hospital length of stay.MethodsA systematic review was conducted for randomized control trials in patients who were hospitalized regardless of age and cause of admission. Studies were collected from PubMed, Web of Science, SCOPUS, and the Cochrane Library until July 2023. Results were compared between the zinc group and those who received a placebo and/or the standard therapy.ResultsEight studies were qualified for our meta‐analysis. Of the 1267 patients, 633 and 634 were in the zinc supplementation and control groups, respectively. The meta‐analysis found that oral zinc supplementation group experienced a lower length of hospital stay than the control group (mean difference, −0.43 days; 95% confidence interval, −0.65 to −0.22; P < 0.0001; heterogeneity, I2 = 20%).ConclusionThe administration of oral zinc supplements was associated with a slightly reduced duration of hospital stay.

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Effect of zinc supplementation on symptom reduction and length of hospital stay among pediatric patients with Coronavirus disease 2019 (COVID-19)

Cited by 3 publications

References 37 publications

Unmasking the enigma: An in-depth analysis of COVID-19 impact on the pediatric population

Unmasking the enigma: An in-depth analysis of COVID-19 impact on the pediatric population

A linear regression analysis of the effect of bioelements on acute respiratory infections incidence in preschool children

Zinc as a potential prophylactic adjuvant therapy for prolonged hospitalization: A systematic review and meta‐analysis of an umbrella of randomized controlled trials

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