Effect of Zinc Supplementation on the Status of Thyroid Hormones and Na, K, and Ca Levels in Blood Following Ethanol Feeding

Pathak, Rajiv; Dhawan, D. K.; Pathak, Ashima

doi:10.1007/s12011-010-8691-4

Cited by 13 publications

(6 citation statements)

References 33 publications

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“…The significant effect of nZnO at 30 mg/kg on serum growth hormone demonstrated in our study was in agreement with the result of Li et al [30] who reported that serum growth hormone level of piglets was elevated in the nano-Zn group than in the other groups. Meanwhile, no significant differences were found among treated groups in respect to serum TSH concentration, which is consistent with the previous report [36]. In contrast, Baweja et al [37] demonstrated that the levels of TSH were elevated after 8-weeks of zinc supplementation in female Westar rats.…”

Section: Discussionsupporting

confidence: 91%

Growth Performance, Serum Biochemical, Economic Evaluation and IL6 Gene Expression in Growing Rabbits Fed Diets Supplemented with Zinc Nanoparticles

Hassan

Mahmoud

El-Araby

2017

Zagazig Veterinary Journal

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Zinc nanoparticles showed a great potential as mineral feed supplements in animals than the conventional sources. However, this potential has not been applied in rabbit nutrition. Therefore, this study was designed to evaluate the effects of dietary nano-zinc oxide on the growth performance, serum biochemical, economic parameters and gene expression of interleukin-6 in growing rabbits. A total of 120 male, five-week-old New Zealand White (NZW) rabbits were randomly distributed into four equal groups. The control group (Z 0) was fed on a basal diet with zinc free premix; the other three experimental groups received the basal diet supplemented with 60 mg zinc oxide/kg diet (Z 1), 60 mg nano-zinc oxide/kg diet (Z 2) and 30 mg nano-zinc oxide/kg diet (Z 3), respectively. The results revealed that rabbits in the groups Z 2 and Z 3 had higher body weight, daily weight gain, daily feed intake, serum total protein, globulin, IgG and SOD when compared with those of groups Z 0 and Z 1 (P<0.001). In addition, growth hormone level was higher in Z 3 group than in the other groups, whereas no significant differences were recorded among the treated groups in respect to serum TSH concentration (P>0.05). Hepatic and serum zinc contents were high in Z 2 and Z 3 groups, but the copper contents were decreased. Rabbits of group Z 3 yielded the highest gross margin with the lowest expenses to produce 1 kg of live weight compared with the others. The production of IL6 in spleen was increased in Z 3 group than that in the other groups. Thus, it can be concluded that nano-zinc oxide at a concentration of 30 mg/kg diet may be used instead of the traditional zinc sources in rabbit diets.

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Section: Discussionsupporting

confidence: 91%

Growth Performance, Serum Biochemical, Economic Evaluation and IL6 Gene Expression in Growing Rabbits Fed Diets Supplemented with Zinc Nanoparticles

Hassan

Mahmoud

El-Araby

2017

Zagazig Veterinary Journal

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“…These experimental studies are expected to improve the clinicians' knowledge about the main supplements being used, in order to clarify the potential risks or side effects and support patients in their use. zinc modulation thyroid function [36][37][38][92][93][94][95][96] inositol involvement in the intracellular TSH signaling, via PIP-3 inositol supplementation decreased circulating T3 and FT3 concentrations thyroid diagnostic oncometabolite the treatment, in combination with seleno-methionine, declined the elevated levels of TSH in patients with AIT and subclinical hypothyroidism immune-modulatory effect of myo-inositol in association with seleno-methionine in patients with euthyroid AIT beneficial effects of myo-inositol, seleno-methionine or their combination on PBMC exposed in vitro to H2O2-induced oxidative stress in both control and women with HT protective effect of myo-inositol on thyroid cells myo-inositol, either alone or in association with T3 improved cardiac lipid content and function of streptozocin-induced diabetic rats Funding: This research received no external funding.…”

Section: Discussionmentioning

confidence: 99%

“…In adult male rats, thyroid function has been slightly damaged by the oral administration of 3 mL 30% ethanol [92]. The moderate decrease in serum T3 and T4 and increase in serum TSH was reversed by the 8-week administration of zinc (Zinc sulfate, 227 mL in the drinking water).…”

Section: Zincmentioning

confidence: 99%

Nutraceuticals in Thyroidology: A Review of in Vitro, and in Vivo Animal Studies

et al. 2020

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Nutraceuticals are defined as a food, or parts of a food, that provide medical or health benefits, including the prevention of different pathological conditions, and thyroid diseases, or the treatment of them. Nutraceuticals have a place in complementary medicines, being positioned in an area among food, food supplements, and pharmaceuticals. The market of certain nutraceuticals such as thyroid supplements has been growing in the last years. In addition, iodine is a fundamental micronutrient for thyroid function, but also other dietary components can have a key role in clinical thyroidology. Here, we have summarized the in vitro, and in vivo animal studies present in literature, focusing on the commonest nutraceuticals generally encountered in the clinical practice (such as carnitine, flavonoids, melatonin, omega-3, resveratrol, selenium, vitamins, zinc, and inositol), highlighting conflicting results. These experimental studies are expected to improve clinicians’ knowledge about the main supplements being used, in order to clarify the potential risks or side effects and support patients in their use.

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“…In humans, zinc supplementation brought the thyroid function back to normality in hypothyroidean patients. The majority of studies on zinc and the HT were focused on zinc supplementation, but these findings were not considered due to being out of the study aim [64,65,66].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Qualitative Dietary Protocol (Diet4Hashi) Application in Dietary Counseling in Hashimoto Thyroiditis: Study Protocol of a Randomized Controlled Trial

Wojtas

Wądołowska

Bandurska-Stankiewicz

2019

IJERPH

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The current state of knowledge related to diet in Hashimoto thyroiditis (HT) is far from satisfactory, as many HT subjects experience several disorders and report reduced quality of life. There are three aims of the study: (1) to develop a qualitative dietary protocol (QDP; ‘Diet4Hashi’) as a simple, graphic–text tool dedicated to TH subjects, (2) to evaluate the use of the QDP in dietetic counseling compared to conventional dietetic counseling (CDC) in HT women, and (3) to assess the impact of both the QDP and the CDC on the diet quality, quality of life, adiposity, and metabolic parameters of HT women. The QDP is based on subject self-monitoring supported with a graphic–text tool to help them in food selection and adequate food frequency consumption, while the CDC on oral explanation and printed sample menus were provided by a dietician. The QDP contains two lists: (A) foods recommended for consumption and (B) foods with limited consumption, along with indicated consumption frequency per day/week/month. Both approaches include the same dietary recommendations for HT extracted from the literature but differ in subject–dietician cooperation. To summarize the evidence regarding dietary recommendations in HT, the PubMed, Embase, and Cochrane Library databases (to March 2019) and the bibliographies of key articles were searched. The study is designed as a dietary intervention lasting six months in two parallel groups: experimental and control. In the experimental group, the QDP will be applied, while in the control group, the CDC will be applied. In total, the study will include a baseline of 100 women with diagnosed HT. The subjects will be randomly allocated into the experimental/control groups (50/50). Data related to diet quality and other lifestyle factors, nutrition knowledge, quality of life, thyroid function, body composition, blood pressure, serum fasting glucose, and lipid profile at baseline and after a six-month follow-up will be collected. This study was conducted to develop a dietary protocol (Diet4Hashi) that is easy to follow for HT subjects, and it will contribute to providing valuable data that are useful to dieticians and physicians. It is anticipated that this graphic–text qualitative dietary protocol, by improving food selection and diet quality, may reduce adiposity and improve metabolic parameters and the quality of life of HT women.

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Effect of Zinc Supplementation on the Status of Thyroid Hormones and Na, K, and Ca Levels in Blood Following Ethanol Feeding

Cited by 13 publications

References 33 publications

Growth Performance, Serum Biochemical, Economic Evaluation and IL6 Gene Expression in Growing Rabbits Fed Diets Supplemented with Zinc Nanoparticles

Growth Performance, Serum Biochemical, Economic Evaluation and IL6 Gene Expression in Growing Rabbits Fed Diets Supplemented with Zinc Nanoparticles

Nutraceuticals in Thyroidology: A Review of in Vitro, and in Vivo Animal Studies

Evaluation of Qualitative Dietary Protocol (Diet4Hashi) Application in Dietary Counseling in Hashimoto Thyroiditis: Study Protocol of a Randomized Controlled Trial

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