Effect of Zingiber officinale on liver oxidative status and biochemical parameters in rats exposed to paraquat

Almasi, Hossein; Habibian, Reza; Kamali, Midia

doi:10.1007/s00580-012-1544-0

Cited by 2 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering the fact that these levels are in the normal range for AST and ALT, it seems that they are not appropriate factors for predicting severe poisoning. Furthermore, in their study, Almasi et al[ 45 ] showed that exposure to paraquat could lead to liver cell damage and increase in AST and ALT levels in rats, which could be treated by prescribing ginger extract. It seems that routine treatment by NAC played a role in improving liver cells’ performance and decreased AST and ALT in a number of patients in this study.…”

Section: Discussionmentioning

confidence: 99%

Discernment scheme for paraquat poisoning: A five-year experience in Shiraz, Iran

Kavousi-Gharbi

Jalli

Kazerouni

et al. 2017

WJEM

View full text Add to dashboard Cite

AIMTo evaluate various schemes for paraquat poisoning and different variables that influence the outcome of acute paraquat poisoning.METHODSIn a cross-sectional study, the information about all cases of acute paraquat poisoning who were admitted to teaching hospitals affiliated to Shiraz University of Medical Sciences, in a five year period (September 2010 to September 2015) were evaluated. The variables included: Demographic data, medical assessment, therapeutic options, laboratory findings, and the outcomes. Data were analyzed using SPSS, version 22. Significant difference between groups was tested using t-test for continues outcomes and χ2 test for categorical. The significance level was considered to be P < 0.05.RESULTSA total of 104 patients (66.3% male) were evaluated. The mean age of the female patients was 22.81 ± 9.87 years and the male patients’ was 27.21 ± 11.06 years. Ninety seven (93.3%) of all the cases were suicide attempts with mortality rate of 43.2%. Despite the necessity for emergency hemodialysis during the first 6 h of intoxication, none of the patients had dialysis during this time. Immunosuppressive and corticosteroid medications were not administrated in adequate dosage in 31.1% and 60% of the patients, respectively. Ingestion of more than 22.5 cc of paraquat and increase in creatinine level were the most important predictors of mortality.CONCLUSIONTreatment should start immediately for these patients. Moreover, creating a clinical guideline according to the findings can have an impact on the treatment procedure which seems to be necessary.

show abstract

Section: Discussionmentioning

confidence: 99%