Effect of Zingiber officinale Roscoe Extract on Antioxidant and Apoptosis in A2058 Human Melanoma Cells

Guon, Tae-Eun; Chung, Ha Sook

doi:10.17495/easdl.2016.6.26.3.207

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…Treatment of cells with Zingiber officinale Roscoe at concentrations of 0, 0.2, and 0.4 mg/mL for 24 hours significantly reduced cell viability. In addition, 70% ethanol extract of Zingiber officinale Roscoe showed antioxidant activity and inhibited the growth of A2058 cells, activating the mitochondrial apoptotic pathway of A2058 cells is mediated by modulating the expression of Bax and Bcl-2, which activates cleavage of caspases-3, caspases-9, and poly ADP-ribose polymerase (Guon et al, 2016). Whereas Oh et al (2018) study showed that Zerumbone (ZER) at concentrations above 20 μM exhibited a strong cytotoxic effect, ZER compounds significantly attenuated melanin accumulation in ⍺-melanocyte-stimulating hormone (α-MSH), stimulating mouse melanogenic B16F10 cells.…”

Section: Zingiber Officinale Roscoementioning

confidence: 99%

Phytochemical Profile and Anticancer Activity from Medicinal Plants Against Melanoma Skin Cancer: A Review

Fristiohady¹,

Asasutjarit²,

Purnama³

et al. 2022

Indonesian J. Sci. Technol

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Melanoma skin cancer is a malignant melanocyte tumor considered the most invasive and dangerous skin cancer, with an average five-year survival rate of less than 5% after metastasis. Thus, a new strategy for preventing and treating cancer from the natural product is required. Medicinal plants are the potential as an alternative against cancer. This review article aims to determine natural products from medicinal plants which have the potential as an anticancer in melanoma skin cancer in vitro and in vivo. 40 plants have been selected based on the selection criteria for anticancer compounds. In vitro studies showed that the plant can reduce cell viability through cell cycle inhibition and apoptosis induction and inhibit angiogenesis, invasion, and metastasis in human melanoma skin cancer. Therefore, further research is required to explore more plants, especially medicinal plants, their active compounds, and the mechanism of anticancer action to be used as standard herbal medicines.

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Section: Zingiber Officinale Roscoementioning

confidence: 99%

Phytochemical Profile and Anticancer Activity from Medicinal Plants Against Melanoma Skin Cancer: A Review

Fristiohady¹,

Asasutjarit²,

Purnama³

et al. 2022

Indonesian J. Sci. Technol

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“…. 생강에 대한 국내 연구는 마우스의 대장염 억제 효과 (Kim et al, 2014), 항산화 효과 (Guon & Chung, 2016;Jung & Park, 2013;Lee et al, 2020), 전립선비대 억제효과 ( Kim et al, 2020), 식품 첨가 관련 연구 (Hwang et al, 2015;Han & Kim, 2011;Lee, 2014) (Kim et al ., 2013a). A, 5 mg/mL; B, 1 mg/mL; C, 0.5 mg/mL; D, 0.25 mg/mL; E, control; -* , No inhibition.…”

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Antibacterial Effect and Deodorization Effect of Extracts from Different Parts of Zingiber officinale

Lee¹,

Kang²,

Ryu³

2020

Asian J Beauty Cosmetol

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Purpose: Using extracts from different parts of Zingiber officinale, we aimed to evaluate its antibacterial effect on skin flora and its deodorization effect on ammonia to determine its potential as an antimicrobial ingredient and functional herbal cosmetic ingredient. Methods: The antibacterial effect on skin flora was examined using the paper disc method and the deodorization effect on ammonia was examined by the gas detection method. Results: After evaluating the antibacterial effects of extracts from different parts (leaves, stems, and roots) of Zingiber officinale, antibacterial activity was observed against Staphylococcus aureus (S. aureus) at a concentration of 5 mg/mL. The leaf, stem, and root extracts had 3 mm, 3 mm, and 2mm clear zones, respectively. For the antibacterial effect against Staphylococcus epidermidis (S. epidermidis), there were 8 mm, 5 mm, and 4mm clear zones for the leaf, stem, and root extracts, respectively. For Propionibacterium acnes (P. acnes), a bacterium that causes acne, there were 4 mm, 3 mm, and 1mm clear zones for the leaf, stem, and root extracts, respectively. The results for Pityrosporum ovale (P. ovale) showed 6 mm, 5 mm, and 4 mm clear zones for the leaf, stem, and root extracts, respectively. For Malassezia furfur (M. furfu), there were 4 mm, 3 mm, and 2 mm clear zones for the leaf, stem, and root extract, respectively. For Candida albicans (C. albicans), there were 4 mm, 3 mm, and 2mm clear zones for the leaf, stem, and root extracts, respectively. Finally, after evaluating the antibacterial effect against Trichophyton mentagrophytes (T. mentagrophytes) at a concentration of 5 mg/mL, we found 6 mm, 4 mm, and 3 mm clear zones for the leaf, stem, and root extracts, respectively. After evaluating the deodorization effects of Zingiber officinale extracts on ammonia, at 120 min, the deodorization effect was 98%, 95%, and 91% for the leaf, stem, and root extracts, respectively. Conclusion: Among the three extracts of Zingiber officinale, the leaf extract had the highest antibacterial effect against the seven types of skin flora as well as the highest deodorization effect, thus confirming its potential as an antibacterial ingredient and functional herbal cosmetic ingredient.

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“…zingerone 등에 기인하며, 이 외에도 flavonoids, terpenoids 등 다양한 생리활성 화합물이 존재하는 것으로 보고되고 있다 (Guon and Chung, 2016). 생강 추출물 중의 하나인 6-gingerol은 cyclooxygenase-2 (COX-2) 활성을 효과적으로 억제한다고 밝혀졌으며 shogaol과 gingerol이 prostaglandin (PG) 및 leukotriene 합성 효소의 효과적인 억제제로 보 고되었다 (Kim et al, 2008).…”

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Modulation Effects on Acute Orofacial Inflammatory Pain in Rats by Curcuma longa L., Curcuma aromatica Salisb., Zingiber officinale Rosc. Extracts

Kim

Choi

Kim

et al. 2019

BSL

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Curcuma longa L. (C.L), Curcuma aromatica Salisb. (C.A) and Zingiber officinale Rosc. (Z.O) of Zingiberaceae plants which are well known as effects of natural anti-oxidant, anti-cancer and anti-inflammatory. We examined that the Zingiberaceae plants are involved in development and modulation of orofacial pain in rats. Male, 7-to 8-week-old, Sprague-Dawley rats weighing 240~280 g were used in this study. Experiments were performed using acute pain model that was caused by the injection of 5% formalin into the right vibrissa pad. The number of scratching or rubbing to the injection site was recorded for 9 consecutive 5-minute intervals following injection of formalin. The experimental groups were acute orofacial inflammatory pain; control group (formalin, 5%), vehicle group (5% formalin after sodium carboxymethyl cellulose), single administration group, single mixed administration group, repeated administration group. The experiments were performed various concentrations of Zingiberaceae plants extract. Therefore, oral administration of C.L, C.A, and Z.O (p.o., concentrations of 12.5, 25 mg/mL) in orofacial inflammatory pain model substantially decrease the nociceptive behavior in a concentration dependent manner. And it tended to decrease at low concentration (12.5 mg/ mL) of single mixed and repeated administration more than single administration. This result means that Zingiberaceae plants extract affects the modulation of acute orofacial inflammatory pain. Thus, Zingiberaceae plants extract may be a potential therapeutic treatment for orofacial inflammatory pain.

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Effect of Zingiber officinale Roscoe Extract on Antioxidant and Apoptosis in A2058 Human Melanoma Cells

Cited by 5 publications

References 27 publications

Phytochemical Profile and Anticancer Activity from Medicinal Plants Against Melanoma Skin Cancer: A Review

Phytochemical Profile and Anticancer Activity from Medicinal Plants Against Melanoma Skin Cancer: A Review

Antibacterial Effect and Deodorization Effect of Extracts from Different Parts of Zingiber officinale

Modulation Effects on Acute Orofacial Inflammatory Pain in Rats by Curcuma longa L., Curcuma aromatica Salisb., Zingiber officinale Rosc. Extracts

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