Effect of Zn and Ga doping on bioactivity, degradation, and antibacterial properties of borate 1393-B3 bioactive glass

Mutlu, Nurshen; Kurtuldu, Fatih; Ünalan, Irem; Neščaková, Zuzana; Kaňková, Hana; Galusková, Dagmar; Michálek, Martin; Liverani, Liliana; Galusek, Dušan; Boccaccını, Aldo R.

doi:10.1016/j.ceramint.2022.02.192

Cited by 39 publications

(24 citation statements)

References 60 publications

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“…These BBGs showed low toxicity on human fibroblast cells. Mutlu et al 98 indicated that zinc oxide doping had a higher inhibitory effect against S. aureus (Gram-positive) bacteria than gallium doping. On the other hand, the two dopants had similar antibacterial effect against Escherichia coli (Gram-negative) bacteria.…”

Section: Applications Of Bbgsmentioning

confidence: 99%

“…These BBGs showed low toxicity on human fibroblast cells. Mutlu et al indicated that zinc oxide doping had a higher inhibitory effect against S. aureus (Gram-positive) bacteria than gallium doping.…”

Section: Applications Of Bbgsmentioning

confidence: 99%

“…The study also indicated that 0.3 and 0.5 mol % doping of BBG led to kerotinocyte migration and promoted wound healing. Gallium and zinc ions increase immune tolerance both in vitro and in vivo. ,, Deliormanlı et al implanted porous BBG scaffolds in the connective tissue of the subcutaneous area of Sprague–Dawley rats, and the histological study indicated that incorporation of up to 5 wt % of cerium oxide ions into the 13-93B3 network significantly increased blood vessel formation. Despite its antibacterial properties, incorporation of up to 3 wt % of gallium ions into 13-93B3 scaffold was shown to reduce angiogenesis in a rat subcutaneous implant model.…”

Section: Applications Of Bbgsmentioning

confidence: 99%

“…77 Studies indicate that ion doping has been found to be efficient against bacteria. 38,94,95,98 Silver oxide, tellurium oxide, cerium oxide, titanium oxide, zinc oxide, and gallium ions have been incorporated in various BBGs, and their antibacterial properties and cytocompatibility have been assessed. Adb-Allah et al 95 indicated that 2 mol % tellurium oxide doped 13-93B3 had higher antibacterial activity against Staphylococcus aureus (S. aureus) than 2 mol % zinc oxide, titanium oxide, and cerium oxide doped BBG.…”

Section: Applications Of Bbgsmentioning

confidence: 99%

See 3 more Smart Citations

Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions

Ege

Zheng

Boccaccını

2022

ACS Appl. Bio Mater.

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Since the early 2000s, borate bioactive glasses (BBGs) have been extensively investigated for biomedical applications. The research so far indicates that BBGs frequently exhibit superior bioactivity and bone healing capacity compared to silicate glasses. They are also suitable candidates as drug delivery devices for infection or disease treatment such as osteoporosis. Additionally, BBGs are also an excellent option for wound healing applications, which includes the availability of commercial (FDA approved) microfibrous BBG dressings to treat chronic wounds. By addition of modifying ions, the bone or wound healing capacity of BBGs can be enhanced. For instance, addition of copper ions into BBGs was shown to drastically increase blood vessel formation for wound healing applications. Moreover, addition of ions such as magnesium, strontium, and cobalt improves bone healing. Other recent research interest related to BBGs is focused on nerve and muscle regeneration applications, while cartilage regeneration is also suggested as a potential application field for BBGs. BBGs are commonly produced by melt-quenching; however, sol–gel processing of BBGs is emerging and appears to be a promising alternative. In this review paper, the physical and biological characteristics of BBGs are analyzed based on the available literature, the applications of BBGs are discussed, and future research directions are suggested.

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Section: Applications Of Bbgsmentioning

confidence: 99%

Section: Applications Of Bbgsmentioning

confidence: 99%

Section: Applications Of Bbgsmentioning

confidence: 99%

Section: Applications Of Bbgsmentioning

confidence: 99%

See 2 more Smart Citations

Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions

Ege

Zheng

Boccaccını

2022

ACS Appl. Bio Mater.

Self Cite

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“…Ga can replace Fe in the cytoplasm but, unlike Fe 3+ , Ga 3+ cannot be reduced to Ga 2+ , and the proteins become inactive [ 96 , 97 ]. Regarding Ga-containing BGs, gallium has been doped into both sol–gel and melt-quenching-derived glasses, and both have shown adequate efficiency against bacteria found in biomaterial-related infections [ 98 , 99 , 100 , 101 ]. Yazdi et al [ 102 ] synthesized a Ga-doped zinc borate bioactive glass manifesting a sustained and controlled release of ions for at least 28 days, which was consistent with the bacteriostatic activity against P. aeruginosa .…”

Section: Metal Ions Incorporated Bioactive Glasses With Antibiofilm E...mentioning

confidence: 99%

Antibiofilm Activity of Biocide Metal Ions Containing Bioactive Glasses (BGs): A Mini Review

Atkinson

2022

Bioengineering

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One of the major clinical issues during the implantation procedure is the bacterial infections linked to biofilms. Due to their tissue localization and the type of bacteria involved, bacterial infections at implant sites are usually difficult to treat, which increases patient morbidity and even mortality. The difficulty of treating biofilm-associated infections and the emergence of multidrug-resistant bacteria are further challenges for the scientific community to develop novel biomaterials with excellent biocompatibility and antibacterial properties. Given their ability to stimulate bone formation and have antibacterial properties, metal ion-doped bioactive glasses (BGs) have received considerable research. This mini review aims to be successful in presenting the developments made about the role of biocide metal ions incorporated into BGs against the development of bacterial biofilms and the spread of nosocomial diseases.

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Zn‐Loaded SBA‐1 and SBA‐15 Molecular Sieves for Combined Antimicrobial and Osteogenic Activity

Trinh

Tran

Arora

et al. 2023

Adv Materials Technologies

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possibilities [1] in various technologically advanced fields, including sensing, [2] energy, [3] catalysis, [4] and biomedical applications. [5] Among these, biomedical applications of mesoporous silica nanoparticles (MSNs) have gained momentum in the past decade with their diverse range of applications in drug delivery systems, bioimaging, biosensors, and biomarker or gene transfection carriers owing to their unique properties such as high surface area and large pore volume, tunable morphology and pore size, affordable surface modification and high bio-compatibility. [6] Recently, MSNs have been explored as artificial substitutes for bone tissue regeneration and remodeling. [7] The initial results gave a promising outlook in which MSNs gradually decomposed in simulated body fluids (SBF) at 37 °C[8] and promoted osteoinduction, osteoconduction, and osteointegration similar to the popular scaffold materials such as bioactive glasses, carbon-based materials, metals/ ceramic composites. [7a,9] Additionally, owing to their ordered porous structure, MSNs were used to load various drugs and antibiotics for bone disease treatment (bisphosphonate, oxytocin, ciprofloxacin), the antimicrobial effect, [10] or were supplemented with factors for supporting bone regeneration (metformin, calcium sulfate). [11] Mesoporous silica-based materials are currently being explored as a new type of bioscaffold for bone regeneration applications. Zinc(Zn) ion incorporation is shown to play an important role in promoting bone regeneration and also providing antimicrobial activity to the scaffold materials. In this work, the role of pore size, geometry, and ordered structure on the Zn loading and release performance of two different mesoporous silica, SBA-1 and SBA-15, are compared. Zn loading is varied from 2.5 to 10 wt% for both samples, and its effect on the antibacterial and osteogenic activity is evaluated. Zn loading up to 10 wt% has a negligible effect on the morphology and textural properties of the mesoporous silica samples. The inductively coupled plasma mass spectrometry (ICP-MS) analysis reveals that SBA-15 exhibits significantly higher Zn release in Luria-Bertani (LB) broth as compared to SBA-1 that is reflected in the higher antibacterial activity of SBA-15 against both gram-positive and gram-negative bacteria. Various assays show that 5 wt% Zn loading is sufficient to produce both bactericidal and inhibitory effects on bacterial cells. The 5 wt% Zn-loaded samples induce osteogenic differentiation ofavianized bone marow-derived stromal cells (TVA-BMSCs) though SBA-15 samples show better compatibility compared to SBA-1, suggesting that Zn incorporation can produce sufficient antibacterial effect and osteogenic differentiation of TVA-BMSCs.

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Effect of Zn and Ga doping on bioactivity, degradation, and antibacterial properties of borate 1393-B3 bioactive glass

Cited by 39 publications

References 60 publications

Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions

Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions

Antibiofilm Activity of Biocide Metal Ions Containing Bioactive Glasses (BGs): A Mini Review

Zn‐Loaded SBA‐1 and SBA‐15 Molecular Sieves for Combined Antimicrobial and Osteogenic Activity

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