Effect of zobo drink (Hibiscus sabdariffa water extract) on the pharmacokinetics of acetaminophen in human volunteers

Abstract

Acetaminophen, a common antipyretic-analgesic OTC drug is often administered orally anytime of the day with water or beverages irrespective of possible interactions. Zobo drink, is a sweetened water extract of the dried calyx of Hibiscus Sabdariffa. This work is designed to investigate the effect of zobo drink on an oral dose of acetaminophen. Six healthy male volunteers, ages 28.50 +/- 1.76 years, weighing 62.67 +/- 1.67kg participated in the study. The study was carried out in two phases. In the first phases an oral dose of acetaminophen (1g) was administered to the volunteers and in the second phases, zobo drink was ingested by the volunteers 1.30 h prior the administration of acetaminophen (1g). Acetaminophen concentration in plasma was determined using a validated spectrophotometric method. Pharmacokinetic values obtained were found to be in similar ranges as those previously reported. The absorption parameters t1/2a, Ka, Tmax, Cmax and AUC0-alpha showed no statistically significant changes (p>0.05) after the administration of zobo. There were however statistically significant changes (p<0.05) in Kbeta and t1/2beta of acetaminophen when administered after the zobo drink. This also resulted in 11.69% increase in ClT.

Identification and quantification of heavy metals in local drinks in Northern Zone of Nigeria

“…Small amount of delphinidin 3-monoglucoside, cyanidin 3-monoglucoside (chrysanthenin), and delphinidin are also present (Bernd and Franz, 1990). Juice made by cooking a quantity of calyces with water is used as a cold drink in the West Indies, tropical America, Jamaica, Mexico, Egypt and Nigeria as "Zobo" (Kolawole and Maduenyi, 2004). Kz is prepared from cereals (millet or guinea corn).…”

Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data

“…Other herbal products that have been implicated in drug interactions include betel nut ( Areca catechu , used for the preparation of a relaxing/refreshing beverage) [224], chlorella (Chlorella pyrenoidosa) , a unicellular fresh water green alga used mainly as a potential source of food and energy and also believed to have some therapeutic benefits [225], boldo (Peumus boldus) used as a choleretic/cholagogue drug [226], fenugreek (Trigonella foenum-graecum) , mostly used for the treatment of hypercholesterolaemia and diabetes mellitus [226], evening primrose oil (Oenothera biennis) , mostly used in dermatology as well as for the treatment of rheumatoid arthritis [227], maitake (Grifolia frondosa) , an edible mushroom with potential anticancer benefits [228], mistletoe (Viscum album) used as a palliative therapy for malignant tumors [229], prickly pear cactus (Opuntia polyacantha) , traditionally used in Mexico for the treatment of diabetes [230], goji (Lycium barbarum) , used in traditional Chinese medicine in cases of loss of energy, diabetes and liver disorders) [231,232], and hibiscus (Hybiscus sabdariffa) , used in folk medicine for the treatment of hypertension [233,234]. Details of such interactions are reported in table 1.…”

<i>In vitro</i> inhibitory activities of the extract of <i>Hibiscus sabdariffa</i> L. (family malvaceae) on selected cytochrome p450 isoforms

“…Prior clinical studies reported a decrease in the terminal half-life of acetaminophen without a significant corresponding change in AUC and clearance (Kolawole and Maduenyi, 2004); a reduction in the metabolic clearance of diclofenac (Fakeye et al, 2008) and a reduction in the bioavailability of chloroquine (Mahmoud et al, 1994) when these drugs were administered concomitantly with the extracts of H. sabdariffa. These drugs are metabolised by more than one CYP isoform: acetaminophen is metabolised by CYP isoforms 1A2, 2A6, 2D6, 2E1 and 3A4 (Patten et al, 1993); diclofenac by CYPs isoforms 2C9 and 3A4 (Tang et al, 1999) and chloroquine is metabolised by CYP2C8, 2D6 and 3A4/5 (Ducharme and Farinotti 1996; Kim et al, 2003).…”

“…Studies have shown that it can be used in the treatment of hypertension and it has actually been shown to have antihypertensive effect comparable to captopril, in man (Odigie et A common practice in some part of the world is the use of juices, sodas and sometimes herbal drinks such as the water beverage of Hibiscus sabdariffa (Zobo) to administer drugs (Huang & Lawrence 2004;Fakeye et al, 2007). The water extract of Hibiscus sabdariffa caused a reduction in the elimination of acetaminophen and diclofenac and also a reduction in the bioavailability of chloroquine (Mahmoud et al, 1994;Fakeye et al, 2007;Kolawole and Maduenyi, 2004). The mechanism responsible for this pharmacokinetic herb-drug interaction has not been fully elucidated.…”