Effect of α-cyclodextrin and surfactants on stability nanoemulsion system of medium chain triglyceride (MCT)

Paramita, Vita; Novia, Sagitha Fitri; Ariyanto, Hermawan Dwi; Pramudono, Bambang; Yoshii, Hidefumi; Kusumayanti, Heny; Amalia, Rizka

doi:10.1016/j.matpr.2022.03.160

Materials Today: Proceedings

2022

DOI: 10.1016/j.matpr.2022.03.160

|View full text |Cite

Effect of α-cyclodextrin and surfactants on stability nanoemulsion system of medium chain triglyceride (MCT)

Vita Paramita

Sagitha Fitri Novia

Hermawan Dwi Ariyanto

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite1

Independent1

Authors

Journals

Cited by 2 publications

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Development and characterization of nanoemulsions containing Lippia origanoides Kunth essential oil and their antifungal potential against Candida albicans

Prado,

de Aguiar,

Prado

et al. 2024

Journal of Applied Microbiology

View full text Add to dashboard Cite

Aims Nanoemulsions based on plant essential oils have shown promise as alternatives against fungal pathogens by increasing the solubility and bioavailability of the active compounds of essential oils, which can improve their efficacy and safety. In the present study, we aimed to prepare and characterize nanoemulsions of Lippia origanoides essential oil, and analyze their antifungal activity against C. albicans in planktonic and biofilm form. Additionally, we sought to verify their cytotoxicity. Methods and Results Alginate nanoemulsions were prepared with different concentrations of essential oil, sunflower oil and surfactant to investigate ideal formulations regarding stability and antifungal efficiency. The results showed the nanoemulsions remained stable for longer than 60 days, with acidic pH, particle sizes ranging from 180.17 ± 6.86 nm to 497.85 ± 253.50 nm, zeta potential from -60.47 ± 2.25 to -43.63 ± 12, and polydispersity index from 0.004 to 0.622. The photomicrographs revealed that the addition of sunflower oil influenced the formation of the particles, forming nanoemulsions. The antifungal results of the essential oil and nanoemulsions showed that the MIC ranged from 0.078 to 0.312 mg mL−1. The nanoemulsions were more effective than the free essential oil in eradicating the biofilm, eliminating up to 89.7% of its mass. With regard to cytotoxicity, differences were found between the tests with VERO cells and red blood cells, and the nanoemulsions were less toxic to red blood cells than the free essential oil. Conclusions These results show that nanoemulsions have antifungal potential against strains of C. albicans in planktonic and biofilm forms.

show abstract

Development and characterization of nanoemulsions containing Lippia origanoides Kunth essential oil and their antifungal potential against Candida albicans

Prado,

de Aguiar,

Prado

et al. 2024

Journal of Applied Microbiology

View full text Add to dashboard Cite

show abstract

Optimization of Lemongrass Oil (Cymbopogon citratus) Emulsion with the Addition of Cethyl Alcohol as a Natural Cosurfactant

Pradasari,

Paramita

2024

Journal of Vocational Studies on Applied Research

Self Cite

View full text Add to dashboard Cite

Lemongrass oil (Cymbopogon citratus) is a plant that produces essential oils as a raw material for fragrance in cosmetics and perfumes. This study aims to determine the optimum conditions for the preparation of Lemongrass oil-wall emulsion (Tween 80 and Cethyl Alcohol) and to determine the effect of the independent variable in the form of the ratio of lemongrass oil-wall to the viscosity produced using the Response Surface Methodology (RSM). The novelty in this research is lemongrass oil with the addition of Tween 80 and Cethyl Alcohol as natural cosurfactants. Tests were carried out with three independent variables, namely stirring time (15, 20 and 25 minutes), stirring speed (20,000, 22,000 and 24,000 rpm) and lemongrass oil-wall ratio (1:3, 1:4, 1:5), which will be designed with the RSM method to obtain optimum operating conditions. Based on the results obtained, the optimal formula for lemongrass oil emulsion is on the 14th running result, which has a pH value of 6.4; density of 0.852; viscosity of 15,450 cP, type M/A, homogeneous and good stability without any change in colour, aroma, and texture. The influence of the lemongrass oil-wall ratio variable, namely the ratio variable, obtained a P-value of 0.000005, which means it is smaller than the value of α = 0.05 so that it can be said that the ratio has a significant effect on the viscosity of the emulsion.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Effect of α-cyclodextrin and surfactants on stability nanoemulsion system of medium chain triglyceride (MCT)

Cited by 2 publications

References 7 publications

Development and characterization of nanoemulsions containing Lippia origanoides Kunth essential oil and their antifungal potential against Candida albicans

Development and characterization of nanoemulsions containing Lippia origanoides Kunth essential oil and their antifungal potential against Candida albicans

Optimization of Lemongrass Oil (Cymbopogon citratus) Emulsion with the Addition of Cethyl Alcohol as a Natural Cosurfactant

Contact Info

Product

Resources

About