Effect of α-tocopherol on the metabolic control and oxidative stress in female type 2 diabetics

Blé-Castillo, Jorge L.; Carmona-Díaz, Elizabeth; Méndez, José D.; Larios-Medina, Francisco J.; Medina-Santillán, Roberto; Villanueva, Cleva; Díaz-Zagoya, Juan C.

doi:10.1016/j.biopha.2005.05.002

Cited by 48 publications

(54 citation statements)

References 39 publications

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“…Subjects on insulin, hormonal therapy, antioxidant supplements, smokers, and with hypertensive were excluded [134]. The investigators reported a 46% reduction in erythrocyte MDA and a significant increase (p < 0.001) in serum total antioxidant in the α-tocopherol group post supplementation when compared to baseline [134]. These results are in conflict with other studies investigating the effect of antioxidant supplementation on oxidative stress markers in subjects with Type 2 DM and may be unreliable.…”

Section: Otherscontrasting

confidence: 54%

“…Most investigators excluded subjects who were already taking the supplement in question, while some asked subjects to stop taking any type of antioxidant supplements weeks prior to the start of the study [129,134]. Gaede et al [6] asked their subjects to stop taking vitamin C and E and ACE-inhibitors 8 weeks prior to the start of the supplementation period, although hypoglycemic drugs continued to be used.…”

Section: Othersmentioning

confidence: 99%

“…Although the investigators documented the percentage of subjects taking oral hypoglycemics, anti-hypertensives, lipid-lowering drugs, aspirin, and statins, analysis of the data did not take account any influence these drugs may have had on the results. In a study by Ble-Castillo et al, Type 2 DM subjects were randomized to receive 800IU α-tocopherol per day (n = 13) or placebo (n = 21) for 6 weeks [134]. Subjects on insulin, hormonal therapy, antioxidant supplements, smokers, and with hypertensive were excluded [134].…”

Section: Othersmentioning

confidence: 99%

“…In a study by Ble-Castillo et al, Type 2 DM subjects were randomized to receive 800IU α-tocopherol per day (n = 13) or placebo (n = 21) for 6 weeks [134]. Subjects on insulin, hormonal therapy, antioxidant supplements, smokers, and with hypertensive were excluded [134]. The investigators reported a 46% reduction in erythrocyte MDA and a significant increase (p < 0.001) in serum total antioxidant in the α-tocopherol group post supplementation when compared to baseline [134].…”

Section: Othersmentioning

confidence: 99%

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Antioxidant properties of drugs used in Type 2 diabetes management: could they contribute to, confound or conceal effects of antioxidant therapy?

Choi

2017

Redox Report

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Objectives: This is a narrative review, investigating the antioxidant properties of drugs used in the management of diabetes, and discusses whether these antioxidant effects contribute to, confound, or conceal the effects of antioxidant therapy. Methods: A systematic search for articles reporting trials, or observational studies on the antioxidant effect of drugs used in the treatment of diabetes in humans or animals was performed using Web of Science, PubMed, and Ovid. Data were extracted, including data on a number of subjects, type of treatment (and duration) received, and primary and secondary outcomes. The primary outcomes were reporting on changes in biomarkers of antioxidants concentrations and secondary outcomes were reporting on changes in biomarkers of oxidative stress. Results: Diabetes Mellitus is a disease characterized by increased oxidative stress. It is often accompanied by a spectrum of other metabolic disturbances, including elevated plasma lipids, elevated uric acid, hypertension, endothelial dysfunction, and central obesity. This review shows evidence that some of the drugs in diabetes management have both in vivo and in vitro antioxidant properties through mechanisms such as scavenging free radicals and upregulating antioxidant gene expression. Conclusion: Pharmaceutical agents used in the treatment of type 2 diabetes has been shown to exert an antioxidant effect..

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Section: Otherscontrasting

confidence: 54%

Section: Othersmentioning

confidence: 99%

Section: Othersmentioning

confidence: 99%

Section: Othersmentioning

confidence: 99%

See 2 more Smart Citations

Antioxidant properties of drugs used in Type 2 diabetes management: could they contribute to, confound or conceal effects of antioxidant therapy?

Choi

2017

Redox Report

View full text Add to dashboard Cite

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“…Our findings may partially explain the inconsistent and mostly disappointing results with antioxidant use in diabetic patients (Darko et al 2002;Heart Protection Study Collaborative Group 2002;Ble-Castillo et al 2005;Lonn et al 2005;Lu et al 2005;Belch et al 2008;Song et al 2009;Kataja-Tuomola et al 2010) since inflammation rather than oxidative stress is the major contributor to diabetes vascular dysfunction. Consistent with this notion, endothelial function improved in type 2 diabetic patients treated with rosiglitazone, an agent that reduces inflammation but not oxidative stress (Kelly et al 2007).…”

Section: Discussionmentioning

confidence: 56%

Weight and inflammation are the major determinants of vascular dysfunction in the aortae of db/db mice

Sallam

Fisher

Golbidi

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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The key roles that obesity, hyperglycemia, hyperlipidemia, inflammation, and oxidative stress play in the progression of diabetes vascular complications are well recognized; however, the relative contribution and importance of these individual factors remain uncertain. At 6, 10, or 14 weeks old, blood samples and thoracic aortae were collected from db/db mice and their non-diabetic controls. Plasma samples were analyzed for glucose, 8-isoprostane, CRP, triglycerides, LDL, and HDL as markers of glycemic status, oxidative stress, inflammation, and dyslipidemia, respectively. The responses of the aortic rings to high KCl, phenylephrine (PE), acetylcholine (ACh), and sodium nitroprusside were examined. Statistical methods were used to estimate the strength of the association between plasma variables and vascular functions. Systemic inflammation occurred in db/db mice at an earlier age than did hyperglycemia or oxidative stress. Aortae of db/db showed augmented contractions to PE which were positively correlated with weight, plasma glucose, 8-isoprostane, and CRP. Also, db/db mice showed impaired endothelium-dependent ACh vasorelaxation which was negatively correlated with weight, plasma glucose, and 8-isoprostane. Multivariate analysis and stepwise modeling show that CRP is the major determinant of the contractile responses, while weight and HDL are the major determinants of ACh-induced relaxation. Among the traditional risk factors of obesity, hyperglycemia, oxidative stress, inflammation, and dyslipidemia, our study reveals that weight and inflammation are the major determinants of vascular dysfunction in the aortae of db/db mice. Our findings partially resolve the complexity of diabetes vasculopathies and suggest targeting weight loss and inflammation for effective therapeutic approaches.

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Targeting Complications of Diabetes with Antioxidants

Golbidi

Laher

2017

Nutritional Antioxidant Therapies: Treatments and Perspectives

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Effect of α-tocopherol on the metabolic control and oxidative stress in female type 2 diabetics

Cited by 48 publications

References 39 publications

Antioxidant properties of drugs used in Type 2 diabetes management: could they contribute to, confound or conceal effects of antioxidant therapy?

Antioxidant properties of drugs used in Type 2 diabetes management: could they contribute to, confound or conceal effects of antioxidant therapy?

Weight and inflammation are the major determinants of vascular dysfunction in the aortae of db/db mice

Targeting Complications of Diabetes with Antioxidants

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