Effect of β₁‐adrenoceptor blockade on plasma levels of atrial natriuretic peptide during exercise in normal man

Abstract

Increased plasma levels of atrial natriuretic peptide (ANP) during exercise have been reported. To investigate the role of tachycardia as a stimulus for release of ANP during exercise the following study was undertaken. Graded exercise was performed in six healthy volunteers before and after beta 1-adrenoceptor blockade. Plasma levels of ANP were determined at different workloads in both cases. At rest and at all workloads during exercise plasma levels of ANP were higher after beta 1-adrenoceptor blockade than without. Therefore, it is unlikely that tachycardia is a major stimulus for secretion of ANP during exercise. It is suggested that increased right atrial pressure and/or pulmonary arterial blood pressure and increased plasma levels of catecholamines are important secretory stimuli for ANP during exercise.

Tertatolol Potentiates Exercise-Induced Atrial Natriuretic Peptide Release by Increasing Atrial Diameter in Healthy Subjects

“…Several studies have shown that exerciseinduced rise in plasma ANP is further en hanced by beta-blockers [8][9][10][11][12][13]. This may re sult from the decreased myocardial contractil ity, decreased frequency of emptying, and raised filling pressure during beta-blockade and/or from direct alphai-adrenoceptor stim ulation.…”

“…Increased resting levels of plasma ANP have been reported with atenolol in healthy subjects [9] and in patients with essential hypertension undergoing long-term treatment with beta-blockers [19]. Both the cardioselective atenolol and the nonselective tertatolol potentiate exercise-induced ANP increase [9,12], and despite their different hemodynamic actions, pindolol and propranolol produce similar rises in resting-and exercise-induced ANP release [11], Thus, beta-blocking drugs, independently of their cardioselectivity or their intrinsic sympathomimetic activity, in crease plasma ANP concentrations at rest and during physical exercise.…”

“…It has been shown that beta-blocking drugs potentiate [8][9][10][11][12][13], and the alpha r adrenoreceptor antagonist prazosin attenuates [13,14], exercise-induced increase in plasma ANP concentrations. The plasma-ANP-increasing effect of beta-blockers may result from the raised atrial distension consequent upon their negative inotropic action or from alpha r adrenergic stimulation due to increased sym pathetic tone during exercise.…”

The Alteration Of Plasma Atrial Natriuretic Peptide Levels Induced By Postural Changes In Archery Athletes

“…[4] Egzersiz kalp debisi, sağ atriyum basıncı ve gerimini artıran bir faktör olduğundan, egzersize bağlı ANP düzeyinde görülen değişimler bu zamana kadar çeşitli çalışmalarla incelenmiş ve ANP salgısının egzersizi takiben arttığı bildirilmiştir. [5][6][7][8][9][10] Plazma ANP düzeyinde egzersiz sonrası artış, sağlıklı kişilerde olduğu gibi, kalp yetmezliği olan [11] ve hipertansif [12] hastalarda da görül-mektedir. Atriyal natriüretik peptid salgısını etkileyen diğer faktörler arasında yapılan egzersizin tipi, cinsiyet, yaş ve postürün olduğu bildirilmiştir.…”

β1-Adrenergic receptor activation decreases ANP release via cAMP-Ca2+ signaling in perfused beating rabbit atria

“…According to many if not all reports, β-adrenoceptor (β-AR) blockade increases plasma atrial natriuretic peptide (ANP) levels in patients with essential arterial hypertension (Nakaoka et al 1987;Papadopoulos et al 1998) or coronary artery disease (Keller et al 1988), and in healthy volunteers (Thamsborg et al 1987;Bouissou et al 1989). β-AR blockade also accentuated plasma ANP levels in a population-based study (Luchner et al 1998).…”