Effect of γ-radiation on a polyanhydride implant containing gentamicin sulfate

Deng, Jie; Li, Luk; Stephens, Dennis; Tian, Yu-Hua; Harris, Frank W.; Cheng, Stephen Z. D.

doi:10.1016/s0378-5173(01)00885-7

Cited by 17 publications

(12 citation statements)

References 12 publications

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“…The aim of this work is to develop new oral controlled release caplets with tuneable release rates with zein as the sole excipient using a simple two-step processing, hot melt extrusion (HME) in combination with injection moulding (IM). The use of HME in combination with IM is a novel and effective way to create tuneable matrix dosage forms with precise shape and dimensions (14,15), which is critical for the systems in which the drug release rate is highly controlled by the dimension and shape of the device.…”

Section: Introductionmentioning

confidence: 99%

The Development of Direct Extrusion-Injection Moulded Zein Matrices as Novel Oral Controlled Drug Delivery Systems

et al. 2015

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Purpose To evaluate the potential of zein as a sole excipient for controlled release formulations prepared by hot melt extrusion.Methods Physical mixtures of zein, water and crystalline paracetamol were hot melt extruded (HME) at 80ºC and injection moulded (IM) into caplet forms. HME-IM Caplets were characterised using differential scanning calorimetry, ATR-FTIR spectroscopy, scanning electron microscopy and powder X-ray diffraction. Hydration and drug release kinetics of the caplets were investigated and fitted to a diffusion model. ResultsFor the formulations with lower drug loadings, the drug was found to be in the noncrystalline state, while for the ones with higher drug loadings paracetamol is mostly crystalline.Release was found to be largely independent of drug loading but strongly dependent upon device dimensions, and predominately governed by a Fickian diffusion mechanism, while the hydration kinetics shows the features of Case II diffusion. ConclusionsIn this study a prototype controlled release caplet formulation using zein as the sole excipient was successfully prepared using direct HME-IM processing. The results demonstrated the unique advantage of the hot melt extruded zein formulations on the tuneability of drug release rate by alternating the device dimensions.

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Section: Introductionmentioning

confidence: 99%

The Development of Direct Extrusion-Injection Moulded Zein Matrices as Novel Oral Controlled Drug Delivery Systems

et al. 2015

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“…Besides affecting the degradation pattern these also affect the physical state of the final polymer, which in turn govern their use either as solid implantable material or directly injectable carrier systems. Owing to the importance of anhydride bond in the controlled drug delivery application, different type of fatty acid polyanhydride biomaterials have been assessed as potential carrier for bioactive agent 3, 5, 6. The major limitation in synthesizing polymer containing fatty acid is the dearth of difunctionality of fatty acid so that it can be integrated in the polymer chain.…”

Section: Introductionmentioning

confidence: 99%

Hydroxy fatty acid based polyanhydride as drug delivery system: Synthesis, characterization, in vitro degradation, drug release, and biocompatibility

Jain

Modi

Kumar

2007

J Biomedical Materials Res

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Low molecular weight hydroxy fatty acid based polyanhydrides were synthesized by one pot method, a variable of typical melt-condensation and characterized by FTIR, NMR, DSC, and GPC. Polymer degrades by both surface and bulk erosion as trailed by weight loss, anhydride loss and surface morphology. Control over drug release was accessed with drugs featuring different aqueous solubility, that is, methotrexate (hydrophobic) and 5-fluorouracil (hydrophilic). Effect of loading, at 5, 10, and 20% w/w of methotrexate on release profiles was also studied and negligible effect was discovered. Biocompatibility of polymers was evaluated in SD rats after SC injection of the polymer. Histopathology revealed initial inflammation of the tissues near the injection site however healed with time. Overall, these polymers were found good to control the release of the entrapped drug and were found biocompatible in preliminary in vivo study. Due to their low melting temperatures they can be injected locally (SC or intratumorally) to from regional in situ depot and have a great potential as a drug carrier for localized delivery of anticancer drugs.

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“…One advantage is that the alternate amide groups in the main chains slow the rate of degradation and the degradation products are the respective nontoxic and compatible amino acids. Another important advantage is that the physical and mechanical properties are raised as a result of the incorporation of hydrogen bonds which reinforce the polymer by intermolecular attractive forces 11. In this study, we synthesized a novel amide‐containing polyanhydride derived from sebacic acid (SA) and L ‐alanine.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and degradation of poly(anhydride‐co‐amide)s and their blends with polylactide

Zhi-qin

et al. 2004

J. Polym. Sci. A Polym. Chem.

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In attempt to improve the properties of polyanhydrides based on aliphatic anhydrides, we synthesized novel polyanhydrides containing amide groups in the main chains. In this work, N,N′‐bis(L‐alanine)‐sebacoylamide (BSAM) was prepared from natural amino acid and sebacic acid (SA) and characterized by IR and 1H NMR. In addition, polymers of PBSAM, P[1,6‐bis(P‐carboxyphenoxy) hexane (CPH)‐BSAM], and P(CPH‐SA), blends of P(CPH‐SA)/polylactide (PLA), P(CPH‐BSAM)/PLA were also prepared and characterized by IR, gel permeation chromatography, and differential scanning calorimetry. The hydrolytic degradation of polyanhydrides and their blends with PLA (number‐average molecular weight = 2.90 × 105) was evaluated in 0.1 M phosphate buffer pH 7.4 at 37 °C. The results indicate that the existence of amide, aromatic, and ester bonds in the main chain of polymers slows down the degradation rate, and the tendency becomes clearer with the increasing amount of them, and the copolymers and their blends with PLA possess excellent physical and mechanical properties. These can make them more widely used in drug delivery and nerve regeneration. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 4311–4317, 2004

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Effect of γ-radiation on a polyanhydride implant containing gentamicin sulfate

Cited by 17 publications

References 12 publications

The Development of Direct Extrusion-Injection Moulded Zein Matrices as Novel Oral Controlled Drug Delivery Systems

The Development of Direct Extrusion-Injection Moulded Zein Matrices as Novel Oral Controlled Drug Delivery Systems

Hydroxy fatty acid based polyanhydride as drug delivery system: Synthesis, characterization, in vitro degradation, drug release, and biocompatibility

Synthesis, characterization, and degradation of poly(anhydride‐co‐amide)s and their blends with polylactide

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