Effect of δ-aminolevulinic acid on growth performance, nutrient digestibility, blood parameters and the immune response of weanling pigs challenged with Escherichia coli lipopolysaccharide

Chen, Y.J.; Kim, I.H.; Cho, J.H.; Min, Byung-Hwa; Yoo, J.S.; Wang, Q.

doi:10.1016/j.livsci.2007.04.015

Cited by 27 publications

(41 citation statements)

References 21 publications

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“…Previous ALA feeding trials in weanling pig models indicated that growth performance was not affected by ALA supplementation, which is in agreement with the current study (Mateo et al, 2006;Chen et al, 2008). An iron depletionrepletion study in chickens using an Fe-defi cient casein-dextrose diet provided clear evidence that dietary iron concentrations were associated with growth performance (Boling et al, 1998).…”

Section: Discussionsupporting

confidence: 93%

“…In the current study, both the bursa of fabricius and spleen weight were signifi cantly increased in the ALA treatment, which to some extent indicated that broilers in this treatment presented better immunity than in the other ones. Similarly, Chen et al (2008) also reported that ALA supplementation at the level of 10 mg/kg had a benefi cial effect on the immune response of weanling pigs during an infl ammatory challenge.…”

Section: Discussionmentioning

confidence: 81%

“…In that study, several other criteria also improved, e.g., serum total protein, iron concentration, as well as WBC and lymphocyte concentrations. According to a recent study, Chen et al (2008) also suggested that dietary ALA supplementation (10 mg/kg) can improve RBC and serum iron levels in weanling pigs. To our knowledge, the current study is the fi rst report of ALA supplementation in broiler diets.…”

Section: Discussionmentioning

confidence: 99%

“…A study conducted by Min et al (2004) reported that dietary ALA supplementation improved the iron status of weanling pigs. Chen et al (2008) also did a further experiment and showed that dietary ALA addition improved the immunity of weanling pigs in a bacteria challenge situation. However, to our knowledge, no study has been performed in chickens yet.…”

Section: Introductionmentioning

confidence: 99%

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Utilization of δ-aminolevulinic acid for livestock: blood characteristics and immune organ weight in broilers

et al. 2008

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A study was conducted to evaluate the effects of δ-aminolevulinic acid (ALA) on blood characteristics and immune organ weight in broilers. One-day-old broiler chicks were randomly assigned to one of four dietary treatments with six replicates of 20 chickens each. Treatments were basal diet supplemented with 0, 5, 10 and 15 mg/kg ALA. The two-phase experimental diets were formulated to meet the NRC requirements for chicks and fed for 5 weeks. Growth performance was not affected by supplementation of ALA during any of the experimental periods. Blood cell counts (WBC, RBC and lymphocyte), serum total protein, albumin, iron concentrations, and total iron binding capacity (TIBC) were also not infl uenced by dietary treatments. Haemoglobin concentration tended to increase with an increased ALA supplementation level (linear effect; P<0.10). Dietary ALA addition did not infl uence liver weight. However, spleen and bursa of fabricius weights were increased with the increased ALA supplementation level (linear effect; P<0.05). The current data indicate that supplementation of ALA in commercial broiler diets could partly improve haemoglobin concentration and immune organ weights, without infl uencing growth performance and other blood characteristics of broilers.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Utilization of δ-aminolevulinic acid for livestock: blood characteristics and immune organ weight in broilers

et al. 2008

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“…The results of studies conducted in weanling pigs demonstrated that dietary 0.05% ALA supplementation could improve Fe, hemoglobin, and lymphocyte concentration (Min et al, 2004) and red blood cell counts (Mateo et al, 2006). Chen et al (2008a) reported that 10 mg kg − 1 ALA can improve DM, N digestibility, the levels of hemoglobin, and WBC counts (Chen et al, 2008a) of blood. Livestock Science 135 (2011 However, the optimal levels of ALA being supplemented in other animals such as poultry are also of interest.…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary delta-aminolevulinic acid and vitamin C on growth performance, immune organ weight and ferrum status in broiler chicks

et al. 2011

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Effects of 5-Aminolevulinic Acid on Gene Expression, Immunity, and ATP Levels in Pacific White Shrimp, Litopenaeus vannamei

Pedrosa-Gerasmio

Tanaka

Sumi³

et al. 2018

Mar Biotechnol

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With the emergence of several infectious diseases in shrimp aquaculture, there is a growing interest in the use of feed additives to enhance shrimp immunity. Recently, the use of 5-aminolevulinic acid (5-ALA), a non-protein amino acid that plays a rate-limiting role in heme biosynthesis, has received attention for its positive effect on immunity in livestock animals. To evaluate the effect of 5-ALA in the Pacific white shrimp, Litopenaeus vannamei, we conducted microarray analysis, a Vibrio parahaemolyticus immersion challenge test, an ATP level assay, and gene expression analysis of some hemoproteins and genes associated with heme synthesis and degradation. Out of 15,745 L. vannamei putative genes on the microarray, 101 genes were differentially expressed by more than fourfold (p < 0.05) between 5-ALA-supplemented and control shrimp hepatopancreas. 5-ALA upregulated 99 of the 101 genes, 41 of which were immune- and defense-related genes based on sequence homology. Compared to the control, the 5-ALA-supplemented group had a higher survival rate in the challenge test, higher transcript levels of porphobilinogen synthase, ferrochelatase, catalase, nuclear receptor E75, and heme oxygenase-1 and higher levels of ATP. These findings suggest that dietary 5-ALA enhanced the immune response of L. vannamei to V. parahaemolyticus, upregulated immune- and defense-related genes, and enhanced aerobic energy metabolism, respectively. Further studies are needed to elucidate the extent of 5-ALA use in shrimp culture.

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Effect of δ-aminolevulinic acid on growth performance, nutrient digestibility, blood parameters and the immune response of weanling pigs challenged with Escherichia coli lipopolysaccharide

Cited by 27 publications

References 21 publications

Utilization of δ-aminolevulinic acid for livestock: blood characteristics and immune organ weight in broilers

Utilization of δ-aminolevulinic acid for livestock: blood characteristics and immune organ weight in broilers

Effects of dietary delta-aminolevulinic acid and vitamin C on growth performance, immune organ weight and ferrum status in broiler chicks

Effects of 5-Aminolevulinic Acid on Gene Expression, Immunity, and ATP Levels in Pacific White Shrimp, Litopenaeus vannamei

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