Effect of ω-3 fatty acid-containing phospholipids on blood catecholamine concentrations in healthy volunteers: a randomized, placebo-controlled, double-blind trial

Hamazaki, Kei; Itomura, Miho; Huan, Mingming; Nishizawa, Hiroto; Sawazaki, Shigeki; Tanouchi, Masatoshi; Watanabe, Shiro; Hamazaki, Tomohito; Terasawa, Katsutoshi; Yazawa, Kazunaga

doi:10.1016/j.nut.2004.07.020

Cited by 99 publications

(59 citation statements)

References 27 publications

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“…Indeed, recent work suggests that even modest supplementation with n-3 PUFAs reduces plasma norepinephrine, an important link to stress responses via NF-κB (52,53).…”

Section: Discussionmentioning

confidence: 99%

Depressive Symptoms, omega-6:omega-3 Fatty Acids, and Inflammation in Older Adults

Kiecolt‐Glaser

Belury

Porter

et al. 2007

Psychosomatic Medicine

196

149

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Objective-Depression and stress promote proinflammatory cytokine production. Dietary intakes of omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) also influence inflammation; high n-6:n-3 ratios enhance proinflammatory cytokine production, while n-3 has anti-inflammatory properties. This study addressed how interactions between PUFA levels and depressive symptoms were related to proinflammatory cytokine synthesis.Methods-Blood samples from 43 older adults (mean age = 66.67, SD=10.09) provided data on PUFAs and TNF-α, IL-6, and sIL-6r. Depressive symptoms were assessed by the CES-D.Results-Depressive symptoms and n-6:n-3 ratios worked together to enhance proinflammatory cytokines beyond the contribution provided by either variable alone, with substantial variance explained by their interaction: 13% for IL-6 and 31% for TNF-α, whereas full models accounted for 18% and 40%, respectively. Although predicted cytokine levels were fairly consistent across n-6:n-3 ratios with low depressive symptoms, higher n-6:n-3 ratios were associated with progressively elevated TNF-α and IL-6 levels as depressive symptoms increased. Higher levels of sIL-6r were associated with higher n-6:n-3 ratios. Six individuals who met criteria for major depressive disorder had higher n-6:n-3 ratios and TNF-α, IL-6, and sIL-6r levels than those who did not meet criteria; excluding these 6 individuals reduced the variance explained by the depressive symptoms and n-6:n-3 ratio interaction.Conclusions-Diets with high n-6:n-3 PUFA ratios may enhance risk for both depression and inflammatory diseases. Keywords depression; proinflammatory cytokines; omega-3; psychoneuroimmunology Depression is the most common psychiatric illness, and both major depression and subthreshold depressive symptoms carry substantial health risks (1,2). A number of wellcontrolled prospective studies have linked depressive symptoms with coronary heart disease (CHD), the leading cause of death in the United States (3); moreover, the nearly 60-fold variance in the annual prevalence of major depression across countries is very similar to the pattern for cardiovascular disease, which shows a strong comorbidity for depression (4,5 Epidemiological studies have demonstrated significant inverse relationships between annual fish consumption and prevalence of major depression (4). Fish oil is the prime source for two key omega-3 (n-3) polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexanoic acid (DHA). Several laboratories have provided evidence that depressed patients have, on average, lower plasma levels of n-3 PUFAs than nondepressed controls; furthermore, there are relationships within these populations between severity of depressive symptoms and lower plasma levels of the n-3 PUFAs (3-6). What is more, all but one of four randomized controlled trials reported significant improvement in the treatment of depression following n-3 PUFA supplementation compared to nonsupplemented controls (6). Significant relationships between lower n...

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“…Indeed, recent work suggests that even modest supplementation with n-3 PUFAs reduces plasma norepinephrine, an important link to stress responses via NF-κB (52,53).…”

Section: Discussionmentioning

confidence: 99%

Depressive Symptoms, omega-6:omega-3 Fatty Acids, and Inflammation in Older Adults

Kiecolt‐Glaser

Belury

Porter

et al. 2007

Psychosomatic Medicine

196

149

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“…In one study of healthy volunteers, O3 reduced plasma noradrenaline (norepinephrine) levels following 8 weeks of supplementation with 400 mg EPA and 300 mg DHA per day, which is associated with decreased activation of the hypothalamic-pituitaryadrenal (HPA) axis (Hamazaki et al 2005). These data suggested that O3 supplementation may lead to greater stability of the HPA axis that could result in lowered anxiety.…”

Section: Treatment Of Anxietymentioning

confidence: 99%

Omega-3 Supplementation for Psychotic Mania and Comorbid Anxiety in Children

Vesco

Lehmann

Gracious

et al. 2015

Journal of Child and Adolescent Psychopharmacology

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Objectives: Therapeutic benefits of omega-3 fatty acids (O3) for mood disorders, psychosis, and anxiety have been reported in the literature. The purpose of the present article is to provide a literature review of O3 supplementation for affective disorders and to illustrate the benefits of O3 with a case presentation of a young girl with a history of bipolar disorder-type 1 with psychotic features and generalized anxiety disorder. Methods: Reviewed literature includes treatment studies of the impact of O3 on child mood disorders supplemented by review of meta-analyses within the adult mood disorders literature. The subject of this case report participated in 11 in-depth diagnostic and functional assessments over 5 years as part of an unrelated study. Three years were presupplementation and 2 years were with supplementation with no other medication changes, thus making a naturalistic multiple-baseline singlesubject experiment. Results: Augmentation over a 2 year period was notable for clinically significant and sustained improvement in depressive, manic, and psychotic symptoms. Conclusion: O3 supplementation may be a safe, adjunct intervention for treating bipolar disorder in children and adolescents, even in the presence of psychotic and anxious features. The 2 year follow-up in this case offers hope of an accumulating and enduring benefit. Further research into mechanisms of O3 action and of combination treatment with other well-known interventions for mood disorders would be beneficial.

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“…Supplements derived from marine foods have been shown to have various functions in animal and clinical experiments. For example, unsaturated fatty acids, 1,2) carotenoids, 3) and functional peptides 4,5) are being increasingly used to treat and prevent a wide variety of lifestyle-related diseases and to improve the quality of life. In this study, we focused on the hepatoprotective effect of the thorny oyster, Spondylus varius.…”

mentioning

confidence: 99%

Hepatoprotective Effect of a Hot-Water Extract from the Edible Thorny OysterSpondylus variuson Carbon Tetrachloride-Induced Liver Injury in Mice

Koyama

Chounan

Uemura

et al. 2006

Bioscience, Biotechnology, and Biochemistry

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Effect of ω-3 fatty acid-containing phospholipids on blood catecholamine concentrations in healthy volunteers: a randomized, placebo-controlled, double-blind trial

Cited by 99 publications

References 27 publications

Depressive Symptoms, omega-6:omega-3 Fatty Acids, and Inflammation in Older Adults

Depressive Symptoms, omega-6:omega-3 Fatty Acids, and Inflammation in Older Adults

Omega-3 Supplementation for Psychotic Mania and Comorbid Anxiety in Children

Hepatoprotective Effect of a Hot-Water Extract from the Edible Thorny OysterSpondylus variuson Carbon Tetrachloride-Induced Liver Injury in Mice

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