Effect on Liver and Splanchnic Circulation of Graded Flow Rates through Portal-Systemic Bypass during Acute Portal Occlusion

Hepatic Oxygen Supply, Energy Charge, and Histological Findings in Dogs with Portal Vein Arterialization.

“…The portcaval shunting, called portal vein anastomosis (PVA), reduces total hepatic blood flow volume (THBF), which results in decreased oxygen supply to hepatic cells because the oxygen supply completely depends on THBF which consists of hepatic artery (HAF) and portal vein blood flow (PVF). It has been generally accepted that the most important factor for maintaining liver functions is oxygen supply to hepatic cells since ligation of the hepatic artery [5,13] or portal vein [7,10,11] induces severe hepatic failure. Therefore, portal vein arterialization in addition to PVA (PA) is considered to be one available technique for preventing liver disfunctions associated with ischemic conditions caused by PVA and/or some hepatic disorders.…”