Effect on splanchnic oxygenation of breast milk, fortified breast milk, and formula milk in preterm infants

Dani, Carlo; Coviello, Caterina; Montano, Simona; Remaschi, Giulia; Petrolini, Chiara; Strozzi, Maria Chiara; Maggiora, Elena; Sabatini, Miriam; Gazzolo, Diego

doi:10.1038/s41390-020-0935-1

Cited by 9 publications

(13 citation statements)

References 19 publications

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“…Recently, Dani et al (2020) 27 hypothesised that enteral feeding induces mesenteric haemodynamic changes in preterm infants, which may vary according to the milk used.…”

Section: Discussionmentioning

confidence: 99%

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LioNeo project: a randomised double-blind clinical trial for nutrition of very-low-birth-weight infants

et al. 2022

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We assessed the effectiveness of lyophilised banked human milk as a fortifier to feed very-low-birth-weight infants (VLBWIs). This study aimed to evaluate the safety and tolerability of human milk (HM) with HM lyophilisate as an additive compared to the standard additive (cow’s milk protein). In this Phase I double-blind randomised controlled clinical trial, set in the intensive and intermediate care units of a tertiary hospital, 40 very-low-birth-weight infants were enrolled and allocated into two groups: HM plus HM lyophilisate (LioNeo) or HM plus commercial additive (HMCA). The inclusion criteria were preterm infants, birth weight 750–1500 g, small or adequate for gestational age, exclusively receiving donor HM, volume ≥ 100 mL/kg/day, and haemodynamically stable. Participants were followed up for 21 consecutive days. The primary outcome measures were necrotising enterocolitis (NEC), late-onset sepsis (LOS), death, gastrointestinal bleeding or perforation, diarrhoea, regurgitation, vomiting, and abdominal distension. The LioNeo and HMCA groups had similar weights at baseline. The regression models showed no differences between the groups in terms of the primary outcomes. Diarrhoea, gastrointestinal perforation, NEC, and LOS were absent in the LioNeo group (1 LOS and 1 NEC in the HMCA group). Multiple regression analysis with the total volume of milk as a covariate did not show significant differences. The lyophilisation of donor HM was considered safe and tolerable for use in stable haemodynamically VLBWIs.

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“…Recently, Dani et al (2020) 27 hypothesised that enteral feeding induces mesenteric haemodynamic changes in preterm infants, which may vary according to the milk used.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Dani et al (27) hypothesised that enteral feeding induces mesenteric haemodynamic changes in preterm infants, which may vary according to the milk used. They evaluated changes in regional splanchnic oxygenation measured by near-IR spectroscopy in infants fed with MOM, fortified human milk (FHM) or preterm formula.…”

Section: Discussionmentioning

confidence: 99%

LioNeo project: a randomised double-blind clinical trial for nutrition of very-low-birth-weight infants

et al. 2022

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“…Dani et al studied the impact of maternal breast milk, fortified human milk, and preterm infant formula on srSO 2 at 30 and 120 min after initiation of a bolus feed in 25–31-week infants. srSO 2 persistently decreased in the preterm formula group, unlike in the two human milk groups, suggesting that formula feeding leads to higher splanchnic FTOE than human milk ( 34 ).…”

Section: Splanchnic Nirsmentioning

confidence: 91%

“…NIRS have been utilized to study the response to various types feeding regimens in the preterm infant population, including breast milk compared to formula and bolus compared to continuous feeds ( 34 – 36 ). Dani et al studied the impact of maternal breast milk, fortified human milk, and preterm infant formula on srSO 2 at 30 and 120 min after initiation of a bolus feed in 25–31-week infants.…”

Section: Splanchnic Nirsmentioning

confidence: 99%

Near-Infrared Spectroscopy in Extremely Preterm Infants

et al. 2021

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With advances in neonatal care, survival of premature infants at the limits of viability has improved significantly. Despite these improvement in mortality, infants born at 22–24 weeks gestation are at a very high risk for short- and long-term morbidities associated with prematurity. Many of these diseases have been attributed to abnormalities of tissue oxygenation and perfusion. Near-infrared spectroscopy utilizes the unique absorption properties of oxyhemoglobin and deoxyhemoglobin to provide an assessment of regional tissue oxygen saturation, which can be used to calculate the fractional tissue oxygen extraction. This allows for a non-invasive way to monitor tissue oxygen consumption and enables targeted hemodynamic management. This mini-review provides a brief and complete overview of the background and physiology of near-infrared spectroscopy, practical use in extremely preterm infants, and potential applications in the neonatal intensive care unit. In this mini-review, we aim to summarize the three primary application sites for near-infrared spectroscopy, disease-specific indications, and available literature regarding use in extremely preterm infants.

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“…We read with interest the paper by Dani et al 1 "Effect on splanchnic oxygenation of breast milk, fortified breast milk (FBM) and formula milk in preterm infants". Necrotising enterocolitis (NEC) remains an important morbidity in neonatal units, yet considerable uncertainties remain about the interaction between milk feeding regimes, use of human milk and milk fortifiers, gut microbiota and disturbances to gut blood flow in the pathogenesis.…”

mentioning

confidence: 99%

Letter to the Editor: Effect on splanchnic oxygenation of breast milk, fortified breast milk and formula milk in preterm infants

et al. 2020

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Effect on splanchnic oxygenation of breast milk, fortified breast milk, and formula milk in preterm infants

Cited by 9 publications

References 19 publications

LioNeo project: a randomised double-blind clinical trial for nutrition of very-low-birth-weight infants

LioNeo project: a randomised double-blind clinical trial for nutrition of very-low-birth-weight infants

Near-Infrared Spectroscopy in Extremely Preterm Infants

Letter to the Editor: Effect on splanchnic oxygenation of breast milk, fortified breast milk and formula milk in preterm infants

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