This paper reviews the findings of experimental and laboratory research to determine whether there is sufficient evidence to support a uniform 0.05% blood alcohol concentration (BAC) as the legal limit for driving. Statistically significant and meaningful decrements in driving-related performance were identified at 0.05% BAC or below in many studies. Younger and inexperienced drinkers and drivers appear to be at greatest risk for alcohol-related traffic crashes. It is concluded that on scientific grounds, there is support for setting the legal limit at 0.05%. The setting of a uniform 0.05% BAC statutory limit should be but one effort within a comprehensive approach including other legal, social, behavioural and environmental strategies to deal with the drink driving problem.