Optical glass is an isotropic amorphous solid material, due to its excellent performance, it has been widely used in various fields. However, during the milling process, the optical glass will have defects such as chipping and cracks on the surface, import and export, and side edges, these defects seriously affect the application of optical glass. In order to study the formation mechanism of defects such as chipping and cracks during optical glass processing, experimental and theoretical study of optical glass milling using ultrasonic vibration-assisted milling (UVAM), the chipping depth model of the export edge collapse was established. The results show that, the main reason for the edge chipping defect is that the optical glass will crack on the subsurface during processing, the propagation of these cracks causes the matrix material to tear and crumble. By comparing and analyzing the results of ultrasonic vibration milling and ordinary milling, ultrasonic vibration can significantly reduce this phenomenon, and it is found that the cutting depth and feed per tooth have a great influence on the export chipping depth value, and the influence of spindle speed is less. In addition, when the amplitude of the ultrasonic wave is applied, not only the import and export edge chipping phenomenon can be significantly improved, but also the surface quality can be significantly improved. Therefore, the application of ultrasonic vibration-assisted milling to the processing of optical glass can improve the surface and edge quality, which is help improve the application range of optical glass.