The goal of the current study was to research the changes in hematological parameters: WBC count, RBCs
count, Hb, PCV, neutrophil, lymphocyte, and monocyte in albino mice infected with Aspergillus fumigatus
by intraperitoneal injection after induced immunosuppression by intraperitoneal injection of cortisone. The
current research also examined an attempt to reduce the infection load by treating with Solanum aculeastrum.
The result shows higher decreased significance (P≤0. 05) in RBCs, Hb, and PCV after being infected with A.
fumigatus 7. 1 ± 0. 8, 11. 3 ± 0. 5 and 41. 5 ± 2. 4, respectively, while the total WBC count, neutrophil,
lymphocyte, and monocytes were increased significantly (P≤0. 05) after treatment with S. aculeastrum in
groups infected with A. fumigatus, compared to other groups. According to these results, we conclude that the
alcoholic extract of S. Astrum has significant therapeutic and antifungal characteristics that lead to an increase
in the total WBC count and, therefore, is considered a necessary alternative therapy for increasing immunity.
Keywords: Cortisone, Hematology, Fungi, Iraq.