2021
DOI: 10.1021/acsami.0c22746
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Effective Antibacterial Activity of Degradable Copper-Doped Phosphate-Based Glass Nanozymes

Abstract: Copper-containing antimicrobials are highly valuable in the field of medical disinfectants owing to their well-known high antimicrobial efficacy. Artificially synthesized nanozymes which can increase the level of reactive oxygen species (ROS) in the bacterial system have become research hotspots. Herein, we describe the design and fabrication of degradable Cu-doped phosphate-based glass (Cu-PBG) nanozyme, which can achieve excellent antibacterial effects against Gram-positive and Gram-negative bacteria. The an… Show more

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Cited by 92 publications
(70 citation statements)
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“…3 ). 54 Different from silver and copper, gold does not readily dissociate into ions due to its higher inertness and stability. 55 It is necessary to endow AuNPs with antibacterial activity by grafting some compounds on their surface.…”
Section: Selective Strategies For the Antibacterial Regulation Of Nan...mentioning
confidence: 99%
“…3 ). 54 Different from silver and copper, gold does not readily dissociate into ions due to its higher inertness and stability. 55 It is necessary to endow AuNPs with antibacterial activity by grafting some compounds on their surface.…”
Section: Selective Strategies For the Antibacterial Regulation Of Nan...mentioning
confidence: 99%
“…Similarly, degradable Cu-doped phosphate-based glass (Cu-PBG) nanozyme has an effective antibacterial activity against Gram-positive and Gram-negative bacteria both in vitro and in vivo, by increasing the level of ROSs and releasing copper [99].…”
Section: Selection Of Amr By Oxidative Stressmentioning
confidence: 99%
“…One of them is AGXX ® —which is composed of two transition metals, silver and ruthenium—causes an oxidative and metal stress response as well as strong protein damage to kill MRSA [ 16 ]. Similarly, degradable Cu-doped phosphate-based glass (Cu-PBG) nanozyme has an effective antibacterial activity against Gram-positive and Gram-negative bacteria both in vitro and in vivo, by increasing the level of ROSs and releasing copper [ 99 ].…”
Section: Selection Of Amr By Other Environmental Stress Factorsmentioning
confidence: 99%
“…On the one hand, some metal ions with anti-biofouling capabilities, such as Cu 2+ and Ag + , are also released into the water system along with the degradation of PSB polymer, which can effectively enhance the anti-biofouling performance. [27,28] On the other hand, the regulation of metal ions is a feasible method to control the mechanical properties and degradation properties of the material. 2) Degradation causes change in the chemical composition of the material interface.…”
Section: Application In Anti-biofoulingmentioning
confidence: 99%