Effective anticancer agents based-on two Pillar[5]arene derivatives for pancreas cancer cell lines: synthesis, apoptotic effect, caspase pathway

Karaselek, Mehmet Ali; Küççüktürk, Serkan; Duran, Tugce; Kurşunlu, Ahmed Nuri; Özmen, Mustafa; Bozdag, Ceren; Alkan, Selman; VARMAN, Alper; Yıldırım, Mehmet Aykut; Küçükkartallar, Tevfik; Vatansev, Celalettin

doi:10.1007/s10637-023-01343-w

Cited by 6 publications

(5 citation statements)

References 31 publications

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“…Experimental results demonstrated that 5Q-P5/10Q-P5 could induce apoptosis by changing cellular behavior and gene expression. [37] Polyamines are essential substances in most organisms that regulate cell proliferation and differentiation. Significantly, the proliferation of various tumor cells is closely related to the concentration of polyamines in cells.…”

Section: Pillararene-based Single Molecule Delivery Systemmentioning

confidence: 99%

“…Experimental results demonstrated that 5Q‐P5/10Q‐P5 could induce apoptosis by changing cellular behavior and gene expression. [ 37 ]…”

Section: Molecular‐scale Pillararene‐based Sdssmentioning

confidence: 99%

Section: Molecular‐scale Pillararene‐based Sdssmentioning

confidence: 99%

mentioning

confidence: 99%

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Pillararene‐Based Stimuli‐Responsive Supramolecular Delivery Systems for Cancer Therapy

Li,

Shen,

Yang

et al. 2024

Advanced Materials

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Cancer poses a significant challenge to global public health, seriously threatening human health and life. Although various therapeutic strategies, such as chemotherapy (CT), radiotherapy, phototherapy, and starvation therapy, have been applied to cancer treatment, their limited therapeutic effect, severe side effects, and unsatisfactory drug release behavior need to be carefully considered. Thus, there is an urgent need to develop efficient drug delivery strategies for improving cancer treatment efficacy and realizing on‐demand drug delivery. Notably, pillararenes, as an emerging class of supramolecular macrocycles, possess unique properties of highly tunable structures, superior host–guest chemistry, facile modification, and good biocompatibility, which have been widely used in cancer therapy to achieve controllable drug release and reduce the toxic side effects on normal tissues under various internal/external stimuli conditions. This review summarizes the recent advance of stimuli‐responsive supramolecular delivery systems (SDSs) based on pillararenes for tumor therapy from the perspectives of different assembly methods and hybrid materials, including molecular‐scale SDSs, supramolecular nano self‐assembly delivery systems, and nanohybrid SDSs. Moreover, the prospects and critical challenges of stimuli‐responsive SDSs based on pillararenes for cancer therapy are also discussed.This article is protected by copyright. All rights reserved

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Section: Pillararene-based Single Molecule Delivery Systemmentioning

confidence: 99%

“…Experimental results demonstrated that 5Q‐P5/10Q‐P5 could induce apoptosis by changing cellular behavior and gene expression. [ 37 ]…”

Section: Molecular‐scale Pillararene‐based Sdssmentioning

confidence: 99%

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Pillararene‐Based Stimuli‐Responsive Supramolecular Delivery Systems for Cancer Therapy

Li,

Shen,

Yang

et al. 2024

Advanced Materials

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“…The compounds were synthesized with a known procedure [19]. The synthesis steps of d-Q-P5 and p-Q-P5 macrocyclic compounds have been shown in Fig.…”

Section: The Synthesis Of D-q-p5 and P-q-p5mentioning

confidence: 99%

Impacts of potential anticancer agents based on pillar[5]arene for head and neck squamous cell carcinoma cells

Küççüktürk

Karaselek

Duran

et al. 2023

J Cancer Res Clin Oncol

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This study was conducted to investigate impacts of potential anticancer (associated with apoptosis and caspase pathways) of two newly synthesized derivatives of pillar[5]arene, named as d-Q-P5 and p-Q-P5, on Squamous cell carcinomas of the head and neck (HNSCC) cells. The MTT method was used to determine the IC 50 doses of the derivatives on HNSCC cells, and the changes in gene expression were analyzed by real-time polymerase chain reaction (qPCR). The apoptosis change was con rmed by ow cytometry analysis. The results showed that the d-Q-P5 and p-Q-P5 effectively inhibited the proliferation of the cells by upregulating proapoptotic genes (Bax, Bad, p53, Bak, and Apaf-1) and genes involved in the caspase pathway (Casp2, Casp3, and Casp9), while downregulating the antiapoptotic gene (Bcl-2). This study is the rst to demonstrate the potential anticancer effects of these two agents on HNSCC cells by positively regulating apoptosis gene expression.

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CRADD and cIAP1 antagonistically regulate caspase-9-mediated apoptosis in teleost

Wu,

Chen,

Yuan

et al. 2024

International Journal of Biological Macromolecules

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Effective anticancer agents based-on two Pillar[5]arene derivatives for pancreas cancer cell lines: synthesis, apoptotic effect, caspase pathway

Cited by 6 publications

References 31 publications

Pillararene‐Based Stimuli‐Responsive Supramolecular Delivery Systems for Cancer Therapy

Pillararene‐Based Stimuli‐Responsive Supramolecular Delivery Systems for Cancer Therapy

Impacts of potential anticancer agents based on pillar[5]arene for head and neck squamous cell carcinoma cells

CRADD and cIAP1 antagonistically regulate caspase-9-mediated apoptosis in teleost

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