Effective antimicrobial activity of rifabutin against multidrug‐resistant <i>Helicobacter pylori</i>

Siavoshi, Farideh; Saniee, Parastoo; Malekzadeh, Reza

doi:10.1111/hel.12531

Cited by 12 publications

(8 citation statements)

References 44 publications

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“…From the 131 articles, 65 were excluded for the following reasons: meta‐analysis, review, non‐original research, conference abstract and article without full text (n = 55), and non‐relevant data or no data for susceptibility testing or no resistance data (n = 10). Finally, 66 studies 4,16‐80 were included in this systematic review and meta‐analysis (Supplementary Table ).…”

Section: Resultsmentioning

confidence: 99%

The increasing antimicrobial resistance of Helicobacter pylori in Iran: A systematic review and meta‐analysis

et al. 2020

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Background Antimicrobial resistance of Helicobacter pylori can result in eradication failure. Metadata on the antimicrobial resistance of H pylori in Iran could help to formulate H pylori eradication strategies in Iran. Methods A systematic review was performed after searching in MEDLINE, Scopus, Embase, Web of Science, and the Cochrane Library. A meta‐analysis was performed, and a comparison of the rates between children and adults; time periods (1999‐2010, 2011‐2016, 2017‐2019); and the methods used was carried out. Results A total of 66 studies investigating 5936 H pylori isolates were analyzed. The weighted pooled resistance (WPR) rates were as follows: clarithromycin 21% (95% CI 16‐26), metronidazole 62% (95% 57‐67), clarithromycin in combination with metronidazole 16% (95% CI 10‐23), ciprofloxacin 24% (95% CI 15‐33), levofloxacin 18% (95% CI 9‐30), erythromycin 29% (95% CI 12‐50), furazolidone 13% (95% CI 4‐27), tetracycline 8% (95% CI 5‐13), and amoxicillin 15% (95% CI 9‐22). During the three time periods, there was an increased resistance to amoxicillin, clarithromycin, ciprofloxacin, furazolidone, and tetracycline (P ˂ .05). Furazolidone and a clarithromycin/metronidazole combination had the higher resistance rates in children (P ˂ .05). Conclusion An increasing rate of resistance to amoxicillin, clarithromycin, ciprofloxacin, furazolidone, and tetracycline in Iranian H pylori isolates was identified. In children, the resistance to furazolidone and a combination of clarithromycin and metronidazole is higher compared to adults. As a stable, high resistance to metronidazole was found in children and adults in all Iranian provinces, we suggest that metronidazole should not be included in the Iranian H pylori eradication scheme.

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Section: Resultsmentioning

confidence: 99%

The increasing antimicrobial resistance of Helicobacter pylori in Iran: A systematic review and meta‐analysis

et al. 2020

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“…35 WHO has categorized clarithromycin-resistant H. pylori to have severely impacted the health of human beings. 6 High primary resistance against clarithromycin (20.9%-96%) has been observed…”

Section: Discussionmentioning

confidence: 99%

Primary antibiotic resistance of Helicobacter pylori in India over the past two decades: A systematic review

Dutta,

Jain,

Das

et al. 2024

Helicobacter

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BackgroundHelicobacter pylori antibiotic resistance has undergone vast changes in the last two decades. No systematic review has been done on the prevalence of antibiotic resistant H. pylori in India in the last two decades. We evaluated the pattern of resistance rates across various regions of India.Materials and MethodsA systematic review of the geographical variations in antibiotic resistance pattern of H. pylori was conducted using PubMed, Google Scholar, Web of Science, Science Direct, etc. for articles published between January 1, 2000 and May 30, 2023. Random effects‐model‐based Cochran's Q test, I2 statistics, and chi‐squared tests were used to measure heterogeneity.ResultsThe overall resistance was highest against metronidazole (77.65%) followed by amoxicillin (37.78%), levofloxacin (32.8%), clarithromycin (35.64%), furazolidone (12.03%), and tetracycline (11.63%). 14.7% of the H. pylori isolates were multi‐drug resistant. Under meta‐analysis of each antibiotic, high heterogeneity levels were observed having I2 ranges from 86.53% to 97.70% at p < 0.0001. In sub‐group analysis, Metronidazole has a stable rate of resistance as compared to other antibiotics. Other antibiotics have had a downtrend in the last 5 years except for levofloxacin, which has had an uptrend in the resistance rate for the past 5 years. Hence, one should avoid using metronidazole for any kind of first‐line treatment.ConclusionsMetronidazole resistance is high in most regions of India except Assam and Mumbai while clarithromycin is found to be ineffective in South India, Gujarat, and Kashmir. As compared to other antibiotics, resistance to amoxicillin is generally low except in certain regions (Hyderabad, Chennai, and the Gangetic belt of North India). Tetracycline and Furazolidone have the least resistance rates and should be part of anti‐ H. pylori regimens. The resurgence of high single and multidrug resistance to the commonly used drugs suggests the need for newer antibiotics and regular resistance surveillance studies.

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“…In the present work, only one strain was resistant to amoxicillin ( Hp1 strain), and no resistant strains to tetracycline were detected. In previous studies, the resistance rate to at least two antimicrobial agents were reported > 35% for H. pylori isolates [ 59 , 60 ]. Our results showed that five of the isolates were resistant to at least two antibiotics (35.7%).…”

Section: Discussionmentioning

confidence: 99%

Procyanidin-Rich Extract from Grape Seeds as a Putative Tool against Helicobacter pylori

Silván

Gutiérrez-Docio

Moreno-Fernández

et al. 2020

Foods

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Strains of Helicobacter pylori (H. pylori) resistant to various antibiotics have increased in recent years. In this context, the search for new therapeutic approaches is crucial. The aim of the present study was to demonstrate the antibacterial activity of a procyanidin-rich extract obtained from food-grade winery grape seeds against 14 H. pylori strains and elucidate its phenolic composition. Ten strains (71.4%) showed resistance to at least some of the tested antibiotics, while four isolates (28.6%) were susceptible to all antibiotics. Resistance to more than one class of antibiotics was observed in six strains (42.9%). The extract was able to inhibit the growth of all H. pylori strains in a range of a minimum inhibitory concentration (MIC) from 0.015 mg/mL to 0.125 mg/mL, confirming also the existence of a strain-dependent effect. The phenolic composition determined by reverse phase high pressure liquid chromatography, photodiode array, and mass spectrometry detection (RP-HPLC-PAD-MS) analysis revealed the presence of 43 individual compounds and allowed the quantification of 41 of them, including seven procyanidin tetramers, seven procyanidin pentamers, and six galloylated procyanidin dimers, trimers, and tetramers. The extract was composed mainly by catechin and procyanidin oligomers with a total amount of 5,801 mg/100 g, which represent 92% of the total individual phenolic content. Among them, the most abundant were catechins (2,047 mg/100 g), followed by procyanidin dimers (1,550 mg/100 g), trimers (1,176 mg/100 g), tetramers (436 mg/100 g), and pentamers (296 mg/100 g) that represent 35, 27, 20, 8, and 5%, respectively of the total flavanol constituents. The composition profile information may help to improve the production process of useful antibacterial extracts against H. pylori.

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Effective antimicrobial activity of rifabutin against multidrug‐resistant Helicobacter pylori

Cited by 12 publications

References 44 publications

The increasing antimicrobial resistance of Helicobacter pylori in Iran: A systematic review and meta‐analysis

The increasing antimicrobial resistance of Helicobacter pylori in Iran: A systematic review and meta‐analysis

Primary antibiotic resistance of Helicobacter pylori in India over the past two decades: A systematic review

Procyanidin-Rich Extract from Grape Seeds as a Putative Tool against Helicobacter pylori

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