Effective Apnea-Hypopnea Index (“Effective AHI”): A New Measure of Effectiveness for Positive Airway Pressure Therapy

Abstract

Significant disease burden, as objectively measured by the Effective AHI, may still exist in many patients with severe OSA in whom PAP therapy is not utilized for the entire sleep period. The WP is a reasonably accurate device to measure the Effective AHI.

Outcome after one year of upper airway stimulation for obstructive sleep apnea in a multicenter German post‐market study

“…The impact of therapy adherence was recognized in the new concept of effective AHI and a new finding on rapid eye movement (REM) AHI. Effective AHI is a measure of treatment effectiveness for CPAP that accounts for OSA events when CPAP is being used (CPAP on) and when it is not (CPAP off) . Boyd et al reported in a cohort of patients with severe OSA an effective AHI of 18.3 ± 16.1 per hour compared with 4.0 ± 2.8 per hour when CPAP on.…”

“…Effective AHI is a measure of treatment effectiveness for CPAP that accounts for OSA events when CPAP is being used (CPAP on) and when it is not (CPAP off). 29 30 The metabolic benefits of CPAP therapy may not be achieved with the typical adherence of 4 hours per night. These studies suggest that an increased therapy adherence may have cardiovascular and metabolic benefits; therefore, UAS as a new OSA treatment option may elucidate these treatment effects in future research.…”

Maxillomandibular Advancement Improves Multiple Health-Related and Functional Outcomes in Patients With Obstructive Sleep Apnea: A Multicenter Study

“…18 Furthermore, a recent study has indicated that CPAP therapy may be necessary for the entire sleep period to predictably control OSA. 19 Several observational studies and meta-analyses have indicated that maxillomandibular advancement (MMA) surgery may be a clinically effective alternative therapy for OSA patients who cannot tolerate CPAP therapy, as measured by changes in the apneahypopnea index (AHI). [20][21][22] MMA also may result in improvement in patient-centered outcomes such as subjective sleepiness [23][24][25] and health-related QOL.…”

Aberrant DNA methylation of the toll-like receptors 2 and 6 genes in patients with obstructive sleep apnea

“…Fifthly, to assess the compliance and adherence of CPAP management by using CPAP >4 hours per night for 6 months might be insufficient. Further reassessment of compliance and adherence of CPAP management by using residual AHI (eg, "effective AHI [43]) is warranted. Sixthly, further in vitro study is needed to establish the cause-and-effect relationship between intermittent hypoxia and aberrant DNA methylation of the TLR2 and TLR6 genes.…”