Effective body recomposition vs. misconceptions of the traditional weight loss strategies: TRCAP21 - a novel technological breakthrough in body recomposition

Abstract

Background: The prevalence of obesity has increased an astounding 30.5% to 42.2% over the last two decades despite numerous weight loss products and programs, thus qualifying it as an epidemic. Fat is the lightest of macromolecules, the highest energy reserve of the body, and the last reservoir of survival insurance to be expended. Water, muscle, and electrolytes are diminished prior to the expenditure of fat resources, the primary cause of rapid weight loss. Contrary to popular belief that only “weight gain” is the sole and correct parameter for evaluating healthy body recomposition, there are no less than 10 additional factors that contribute to a reduction in metabolic rate and an increase in fat storage. These are mostly ignored from considerations regarding the etiology of obesity. Our laboratory developed a novel formulation of D-ribose nicotinamide, alpha glycerol phosphorylcholine and four other evidence-based botanical constituents encapsulated in a Prodosomed stimulant- and sugar-free TRCAP21 (TrimRoxTM) formulation that effectively addresses those contributing factors. To investigate the feasibility of doing a 90-day randomized, double-blind placebo-controlled investigation, we conducted a 21-day concept validation pilot study on TRCAP21 in 9 subjects to assess changes in various body parts, including chest, upper arms, waist/belly, hips, and thighs, as well as body weight. Objective: This physician-supervised 21-day concept validation pilot study on TRCAP21 was conducted on 9 subjects to determine changes in anthropometric parameters including chest, upper arms, waist/belly, hips, and thighs, as well as body weight, and determine the effect of TRCAP21 on energy, mood, satiety, and sugar cravings.Materials and Methods: The study was conducted on nine male and female subjects (age: 47-70 years) to assess the efficacy of TrimRoxTM over a period of 21 consecutive days. Body weights and anthropometric measurements were conducted at the initiation and termination of the study. The effect of TRCAP21 was evaluated on energy level, mood elevation, satiety level, sugar cravings, overall health, and adverse events in the subjects.Results: The results demonstrated that all subjects experienced a reduction in size of one or more these body parts. In addition, it also led to significant improvements in mood elevation, satiety, reduced sugar cravings, elevated energy levels and overall mental and physical health. Intake of 1 packet twice a day (BID) before meals resulted in a significantly greater reduction of body measurements than consuming it once a day (OID). Surprisingly, body weight was reduced in all nine subjects from 2 lbs. to 11 lbs. The randomized double-blind placebo-controlled study is underway to confirm and further substantiate these findings. Conclusion: The TRCAP21 Prodosomed nutraceutical formulation combines the evidence-based efficacy of 6 key constituents, mostly of botanical origin, that act synergistically to restore aerobic cellular metabolism, boost energy level, mood elevation, improve satiety, reduce sugar cravings, reduce body fat in various body compartments as well as weight and improve overall health. Owing to the encapsulation of the components in unique concentric layers of liposome, their release takes place in a sustained and sequential manner. It will be worthwhile to explore its effect on the Gut-Brain Axis, especially the associated microbiome in order to obtain further insights to more accurately define the multiple mechanisms of action.Keywords: obesity, weight management, body recomposition, Aerobic body homeostasis, prodosome®, herbal nutraceuticals

Inflammatory responses and obesity: Nutrition as an epigenetic modulator

“…When the inflammatory response lingers and continues for a longer time, while the immune support system continues to provide white blood cells and multiple chemical messengers that lengthen the process, it is termed chronic inflammation. [1,5,6] Under these lengthy stressful conditions, white blood cells get distracted/misguided and finally invade the adjoining healthy cells, tissues, and organs. Chronic and low-grade inflammation becomes a silent killer that contributes to an array of diverse degenerative disorders including cardiovascular disease, arthritis, type 2 diabetes mellitus (T2DM), metabolic distress/syndrome, inflammatory bowel diseases (Crohn's disease) and ulcerative colitis, cancer, and diverse infectious conditions/diseases.…”

“…e cascade of events takes place including (a) enhanced oxidative stress and increased oxidative tissue damage, (b) increased immune system distress and exhaustion, which in turn can also trigger 'survival panic'; (c) premature aging; and (d) impaired aerobic metabolism, causing increased anaerobic glycolysis and metabolism, and drastically reducing AMPK levels, which is termed the energy coin. [5][6][7][8] Accumulation of atypical and uncontrolled growth of excessive fat is termed obesity, which interferes with the maintenance of healthy metabolism. e longer an individual is obese, the longer the body will exhibit a state of inflammation.…”

“…Placing a primary focus on the heaviness of the body or overweight does not provide an accurate perspective for determining healthy changes in metabolism, body composition, or size of the individual. [6] Fat is the lightest macromolecule in the human body and the last to be eliminated in the body…”

“…When the body is put into a survival mode, that is, survival panic, it upregulates survival insurance storage of these components, retards energy expenditure, and increases energy conservation, and brown and white adipose tissue deposition. [6,9] To combat the skyrocketing progression of obesity and metabolic syndrome around the world, it is important to explore different strategies of utilizing appropriate natural phytotherapeutics [Table 1] in conjunction with regular exercise and appropriate diet to combat obesity, metabolic syndrome, and attain a healthy and balanced lifestyle. [6] An ideal strategy will be to incorporate these ingredients to ideally synergize the gut-brain axis and appropriately influence the human gut microbe associations for optimal body homeostasis and achieve the system biology benefits noted in the table.…”

“…[6,9] To combat the skyrocketing progression of obesity and metabolic syndrome around the world, it is important to explore different strategies of utilizing appropriate natural phytotherapeutics [Table 1] in conjunction with regular exercise and appropriate diet to combat obesity, metabolic syndrome, and attain a healthy and balanced lifestyle. [6] An ideal strategy will be to incorporate these ingredients to ideally synergize the gut-brain axis and appropriately influence the human gut microbe associations for optimal body homeostasis and achieve the system biology benefits noted in the table. [23,24] CONCLUSION Two intricate molecular mechanisms adjudicate epigenetic modulation in a biological system, which are (a) DNA methylation and (b) histone modification.…”