Effective combined therapy for pulmonary epithelioid hemangioendothelioma: A case report

Intradural Extramedullary Epithelioid Hemangioendothelioma of the Thoracic Spinal Cord: A Case Report

“…Reported chemotherapy regimens include (1) bevacizumab monotherapy; carboplatin, pemetrexed, and bevacizumab; carboplatin and etoposide; and adriamycin, dacarbazine, and ifosfamide for cytotoxic chemotherapy; (2) interferon alpha; and lenalidomide for immune therapy; (3) apatinib; sorafenib; pazopanib; and sirolimus for targeted therapies; and (4) combined chemotherapy such as apatinib combined with doxorubicin and cyclophosphamide. 19,20) In this case, surgical resection of intradural extramedullary EHE was effective for improving the patient's neurological findings, but a long-term outcome was poor without adjuvant therapies.…”

Hemangioendotelioma cardiaco primario recurrente: reporte de caso y revisión de la literatura

“…La quimioterapia ha sido usada en tumores avanzados y localizados en tejidos profundos. 38,39 Zhang et al 40 han usado el esquema apatinib asociado a doxorrubicina/ciclofosfamida en un HEE pulmonar con buen resultado y una supervivencia a los 24 meses. Según Din et al 41 de 7 casos 3 recibieron quimioterapia en HEE hepático; uno de ellos recibió carboplatino (3 ciclos) sin respuesta completa desarrollando metástasis pulmonar y muerte a los 5 años, otro paciente sin respuesta completa a la quimioterapia falleció a los 6 meses y el último paciente recibió pazopanib con una respuesta parcial, con un promedio de supervivencia de 2 años.…”

Soft Tissue Epithelioid Vascular Tumors: A Practical Clinico Pathological Diagnostic Approach

“…In a 64-year-old female patient with EHE of the lung, four cycles of apatinib combined with doxorubicin/cyclophosphamide were administered with stabilization of multiple bilateral nodules and significant improvement of disease-related symptoms such as chest tightness, chest pain and cough. Since the patient did not tolerate the combination treatment (due to nausea and neutropenia grade 3-4), chemotherapy was interrupted and she continued with apatinib monotherapy; the disease remained stable at a follow up of after 24 months (48).…”