Effective Dosage of Lactic Fermented Soymilk for Improving Lipid Metabolism in Rats

Harada, Tomoko; Tanaka, Maki; Tsuzuki, K.; Sugawara, Makoto; Takagi, Naohiro; Fukuda, Mitsuru

doi:10.3136/nskkk.57.175

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…The effects of lactic acid-fermented soymilk on lipid metabolism in rats fed an AIN-93G diet have been known [ 19 , 20 ]. In our previous paper [ 23 ], it was found that fermented soymilk diet containing 10% soy protein as final concentration was necessary to significantly enhance the lipid metabolism modulation in rats fed a cholesterol-free diet. Thus, in the present study, we examined the dose response of the lipid metabolism-modulation effect by using different concentrations of fermented soymilk in rats fed a high cholesterol diet.…”

Section: Discussionmentioning

confidence: 99%

Hypocholesterolemic Effects of Lactic Acid-Fermented Soymilk on Rats Fed a High Cholesterol Diet

Kobayashi

Hirahata

Egusa³

et al. 2012

Nutrients

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The effect of fermented soymilk on rats fed a high cholesterol diet was investigated to clarify the cholesterol-lowering function. Male Sprague-Dawley rats aged 7 weeks were fed a control diet (1% cholesterol, high cholesterol diet), high cholesterol diet containing 11.7% fermented soymilk diet (5% soy protein as final concentration, F-5), or high cholesterol diet containing 23.4% fermented soymilk diet (10% soy protein as final concentration, F-10) for 5 weeks. The liver weight and fat mass were decreased by the ingestion of fermented soymilk. The hepatic triglyceride and cholesterol levels in the F-5 and F-10 groups were significantly lowered compared to those in the control group. The plasma total cholesterol level of the F-10 group was significantly decreased. The expression of SREBP-2, a cholesterol synthesis-related gene, was significantly decreased in liver of the F-5 group, but the expression of CYP7a1, a cholesterol catabolism-related gene, was significantly increased. These results suggest that fermented soymilk can modulate the cholesterol metabolism in rats fed a high cholesterol diet.

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Section: Discussionmentioning

confidence: 99%

Hypocholesterolemic Effects of Lactic Acid-Fermented Soymilk on Rats Fed a High Cholesterol Diet

Kobayashi

Hirahata

Egusa³

et al. 2012

Nutrients

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show abstract

“…We have previously reported that fermented soymilk reduced the plasma and hepatic cholesterol concentrations in rats fed on a high-cholesterol diet 13) and that more than a 10% of soy protein in the diet was necessary to achieve a significant physiological effect on rats fed with a cholesterol-free diet by ingesting fermented soymilk. 14) Fermented soymilk prepared by using bifidobavterium breve YIT 4065 has been reported to improve the lipid metabolism. 12,15) We investigated in our previous study 16) the effects of lactic acid-fermented soymilk containing okara on the plasma and hepatic lipid profiles and expression of the lipid metabolism-related genes in rats.…”

mentioning

confidence: 99%

Effects of Lactic Acid-Fermented Soymilk on Lipid Metabolism-Related Gene Expression in Rat Liver

Kobayashi¹,

Harada²,

Takagi³

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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Effective Dosage of Lactic Fermented Soymilk for Improving Lipid Metabolism in Rats

Cited by 2 publications

References 13 publications

Hypocholesterolemic Effects of Lactic Acid-Fermented Soymilk on Rats Fed a High Cholesterol Diet

Hypocholesterolemic Effects of Lactic Acid-Fermented Soymilk on Rats Fed a High Cholesterol Diet

Effects of Lactic Acid-Fermented Soymilk on Lipid Metabolism-Related Gene Expression in Rat Liver

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