Effective doses of some cholinolytics in the treatment of anticholinesterase poisoning

Jović, R; Мilošević, Мiloš

doi:10.1016/0014-2999(70)90032-4

Cited by 23 publications

(2 citation statements)

References 8 publications

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“…We are in agreement with the hypothesis put forth by Jovic and Milosevic [36] that inhibition of cholinesterase by OP leads to such extensive alterations in function that a single‐compound treatment capable of counteracting all manifestations of the poisoning would be difficult, if not impossible, to achieve. Current therapeutic drugs that directly reactivate inhibited AChE are of little value in treatment unless combined with drugs that counteract the effects of accumulated ACh.…”

Section: Discussionsupporting

confidence: 91%

The use of carbamates, atropine, and 2-pyridine aldoxime methoiodide in the protection of Artemia salina against poisoning by carbophenothion

Sánchez-Fortún

Barahona

2001

Environmental Toxicology and Chemistry

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The acute toxicity of carbophenothion to three age classes of Artemia salina was evaluated. An increase in toxicity of carbophenothion was found following longer development of A. salina. The effect of pretreatment with the nonselective muscarinic antagonist atropine, the two reversible acetylcholinesterase-inhibitors physostigmine and pyridostigmine, and the cholinesterase-reactivating oxime 2-pyridine aldoxime methochloride (2-PAM) on carbophenothion-induced lethality in 24-h-old A. salina was also investigated. The lethal action of carbophenothion was completely prevented by pretreatment of A. salina with 2-PAM. Atropine and pyridostigmine afforded a maximal protection of approximately 87% and 72%, respectively, compared to control values. In contrast, physostigmine was ineffective. The inhibitory effects of combinations of 10(-5) M atropine with physostigmine, pyridostigmine, or 2-PAM were greater than those elicited by either drug alone, with the maximum protection afforded being 92.58%, 100%, and 100%, respectively. In the presence of 10(-7) M atropine, neither pyridostigmine nor 2-PAM provided additional inhibition of the lethality compared to that with either drug alone, whereas the protection afforded by 10(-7) M atropine plus physostigmine increased as the concentration of carbamate increased (up to 10(-3) M). Pretreatment with pyridostigmine or physostigmine plus 2-PAM (10(-6) M) slightly enhanced the maximal inhibition of carbophenothion lethality compared to that with either drug alone. It is suggested that the most active combined pretreatment studied here was physostigmine plus atropine.

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Section: Discussionsupporting

confidence: 91%

The use of carbamates, atropine, and 2-pyridine aldoxime methoiodide in the protection of Artemia salina against poisoning by carbophenothion

Sánchez-Fortún

Barahona

2001

Environmental Toxicology and Chemistry

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“…Notwithstanding, the use of scopolamine in medical management of OP toxicities pales in comparison to atropine despite evidence that seemed to suggest that scopolamine may be a more effective antidote than atropine (e.g., Anderson et al, 1994;Bertram et al, 1977;Capacio and Shih"1991;Harris et al, 1991;1994;Lennox et al, 1992;Janowsky et al, 1984;Jovic and Milosevic, 1970;Leadbeater et al, 1985;McDonough and Shih, 1993;Solana et al, 1991;Wescoe et al, 1948;Wills, 1963). In addition to its general antidotal effects, research from this institute Harris et al, 1994) has shown that scopolamine appeared to be a notably more powerful anticonvulsant than benzodiazepine derivatives (such as diazepam and midazolam) in animals intoxicated by soman (an extremely toxic chemical warfare agent).…”

Section: Dtsritsstonfmentioning

confidence: 99%

Scopolamine Antagonizes the Lethal Effects of O-isobutylS-2-(DIETHYLAMINO)ETHYL-methylphosphonothioatc (VR)

Chang¹,

DeBus²

2003

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Behavioral Toxicity of Anticholinesterase Agents: Methodological, Neurochemical, and Neuropsychological Aspects

Bignami

Rosić

Michałek

et al. 1975

Behavioral Toxicology

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Effective doses of some cholinolytics in the treatment of anticholinesterase poisoning

Cited by 23 publications

References 8 publications

The use of carbamates, atropine, and 2-pyridine aldoxime methoiodide in the protection of Artemia salina against poisoning by carbophenothion

The use of carbamates, atropine, and 2-pyridine aldoxime methoiodide in the protection of Artemia salina against poisoning by carbophenothion

Scopolamine Antagonizes the Lethal Effects of O-isobutylS-2-(DIETHYLAMINO)ETHYL-methylphosphonothioatc (VR)

Behavioral Toxicity of Anticholinesterase Agents: Methodological, Neurochemical, and Neuropsychological Aspects

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