Effective Enrichment of Plasmonic Hotspots for SERS by Spinning Droplets on a Slippery Concave Dome Array

Wu, Jialin; Cai, Jianpeng; Fan, Y. X.; Zhang, Ying; Fang, Hui; Yan, Sheng

doi:10.3390/bios12050270

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…Surface-enhanced Raman spectroscopy (SERS) is a highly sensitive method that provides the “fingerprint” information on analytes and has been used for identification and quantification of a wide range of analytes including chemicals, metabolites, macromolecules, and microorganisms. − Since the Raman scattering from the analytes is ultra weak, the plasmonic nanostructures are prepared to greatly enhance the Raman scattering of analytes, even enabling the single-molecule detection . Great efforts have been made to explore the utilization of SERS for sweat detection.…”

Section: Introductionmentioning

confidence: 99%

Self-Adhesive, Biocompatible, Wearable Microfluidics with Erasable Liquid Metal Plasmonic Hotspots for Glucose Detection in Sweat

Yuan,

Fang,

et al. 2023

ACS Appl. Mater. Interfaces

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Sweat is a noninvasive metabolite that can provide clinically meaningful information about physical conditions without harming the body. Glucose, a vital component in sweat, is closely related to blood glucose levels, and changes in its concentration can reflect the health status of diabetics. We introduce a self-adhesive, wearable microfluidic chip with erasable liquid metal plasmonic hotspots for the precise detection of glucose concentration in sweat. The self-adhesive, wearable microfluidic chip is made from modified polydimethylsiloxane (PDMS) with enhanced stickiness, enabling conformal contact with the skin, and can collect, deliver, and store sweat. The plasmonic hotspots are located inside the microfluidic channel, are generated by synthesizing silver nanostructures on liquid metal, and can be removed in the alkaline solution. It indicates the erasable and reproducible nature of the plasmonic hotspots. The detection method is based on surface-enhanced Raman spectroscopy (SERS), which allows for accurate detection of the glucose concentration. To enhance the sensitive detection of glucose, the SERS substrate is modified by 4-mercaptophenylboronic acid to achieve the limit of detection of 1 ng/L glucose, which is much lower than the physiological conditions (7.2–25.2 μg/L). The developed microfluidic chip is soft, stretchable, and nontoxic, bringing new possibilities to wearable sweat-sensing devices.

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Section: Introductionmentioning

confidence: 99%

Self-Adhesive, Biocompatible, Wearable Microfluidics with Erasable Liquid Metal Plasmonic Hotspots for Glucose Detection in Sweat

Yuan,

Fang,

et al. 2023

ACS Appl. Mater. Interfaces

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“…In recent years, hydrophobic materials have attracted more and more attention. They have broad application prospects in metal corrosion prevention [ 27 , 28 ], self-cleaning [ 29 , 30 ], oil-water separation [ 31 , 32 ], surface-enhanced Raman spectroscopy [ 33 , 34 ] and other aspects. In general, the surface hydrophobicity of solid materials is mainly affected by two factors, the rough structure and chemical composition of the surface.…”

Section: Introductionmentioning

confidence: 99%

Quantitative SERS Detection of TBBPA in Electronic Plastic Based on Hydrophobic Cu-Ag Chips

et al. 2022

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Tetrabromobisphenol A (TBBPA) was one of the most widely used brominated flame retardants. However, it easily contaminates nature and harms the environment and human health during its production and use. Therefore, it is necessary to strictly control the content of TBBPA in electronics. Surface-enhanced Raman spectroscopy has the advantages of being fast and sensitive, but it is difficult to obtain the SERS spectra of TBBPA because the hydrophobic TBBPA molecule is difficult to approach with the hydrophilic surface of common noble metal SERS substrates. In the present work, a hydrophobic Cu-Ag chip was developed for the SERS detection of TBBPA. The integration of the hydrophobic interaction and the Ag-Br bonding promoted the adsorption of TBBPA on the Cu-Ag chip, allowing for SERS detection. It was observed that both the hydrophobicity and bimetallic composition of the Cu-Ag chip played important roles in the SERS detection of TBBPA. Under the optimized conditions, the low limit of detection of the established SERS method for TBBPA was 0.01 mg L−1, within a linear range of 0.1–10 mg L−1. Combined with ultrasonic-assisted extraction, the substrate could be used for the quantitative determination of TBBPA in electronic products. Compared with the HPLC-UV method used as a national standard, the relative error of the SERS method for quantifying the TBBPA content in a mouse cable and shell was ±3% and ±7.7%, respectively. According to the SERS results, the recovery of TBBPA in the spiked mouse shell was 95.6%.

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“…For example, Liang Zhang et al employed evaporation-induced relatively uniform transients to detect creatinine in human serum to avoid the “coffee-ring” effect . Some research groups increased the resistance of analyte molecules to radial outward flow by using a hydrophobic substrate − and decreased droplet deposition on the contact line by using electrically controlled enrichment, , among other things. Although these methods have improved the detection reproducibility by effectively avoiding the “coffee-ring” effect, there are still some problems that need to be solved.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Detection Reproducibility of Surface-Enhanced Raman Scattering by Controlling Analytes under One Laser Spot

et al. 2022

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Surface-enhanced Raman scattering (SERS), as a sensitive analytical technique, is expected to be used for quantification of trace analytes. At the current stage, high detection reproducibility should be guaranteed for realizing quantification analysis of trace analytes. The main obstacle to achieving high detection reproducibility is the nonuniform distribution of analyte molecules on substrates, particularly, the “coffee-ring” effect introduced by the flow of solute to the pinning of the contact line. Herein, we report a method to tackle this problem by controlling the location of analytes through tuning the wettability of the SERS substrate. With the combination of silver-assisted chemical etching and photolithography, the ordered Si patterns grafted silver nanoparticles with tunable wettability were integrated into a SERS substrate. With this substrate, high detection reproducibility was achieved by confining all the analyte molecules on the area of active plasmonic hot-spots within one laser, and the quantitative analysis was realized with ultrahigh sensitivity. Furthermore, the substrate is applicable for high-throughput detection.

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Effective Enrichment of Plasmonic Hotspots for SERS by Spinning Droplets on a Slippery Concave Dome Array

Cited by 6 publications

References 27 publications

Self-Adhesive, Biocompatible, Wearable Microfluidics with Erasable Liquid Metal Plasmonic Hotspots for Glucose Detection in Sweat

Self-Adhesive, Biocompatible, Wearable Microfluidics with Erasable Liquid Metal Plasmonic Hotspots for Glucose Detection in Sweat

Quantitative SERS Detection of TBBPA in Electronic Plastic Based on Hydrophobic Cu-Ag Chips

Enhancing Detection Reproducibility of Surface-Enhanced Raman Scattering by Controlling Analytes under One Laser Spot

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