2015
DOI: 10.1002/jmr.2466
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Effective epitope identification employing phylogenetic, mutational variability, sequence entropy, and correlated mutation analysis targeting NS5B protein of hepatitis C virus: from bioinformatics to therapeutics

Abstract: Hepatitis C virus (HCV) is considered as a foremost cause affecting numerous human liver-related disorders. An effective immuno-prophylactic measure (like stable vaccine) is still unavailable for HCV. We perform an in silico analysis of nonstructural protein 5B (NS5B) based CD4 and CD8 epitopes that might be implicated in improvement of treatment strategies for efficient vaccine development programs against HCV. Here, we report on effective utilization of knowledge obtained from multiple sequence alignment and… Show more

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Cited by 3 publications
(1 citation statement)
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“…A recent study by (Chawla et al, 2023) has used immunoinformatic techniques to predict and evaluate T-cell epitopes in the spike protein of the virus, paving the way for more targeted vaccine strategies. Another promising research direction is the identification of potential epitopes for FIPV using phylogenetic analysis, which can aid in the design of effective preventive measures (Aksono et al, 2023;Meshram & Gacche, 2015).…”
Section: Introductionmentioning
confidence: 99%
“…A recent study by (Chawla et al, 2023) has used immunoinformatic techniques to predict and evaluate T-cell epitopes in the spike protein of the virus, paving the way for more targeted vaccine strategies. Another promising research direction is the identification of potential epitopes for FIPV using phylogenetic analysis, which can aid in the design of effective preventive measures (Aksono et al, 2023;Meshram & Gacche, 2015).…”
Section: Introductionmentioning
confidence: 99%