Effective Evaluation of Finger Sensation Evoking by Non-Invasive Stimulation for Sensory Function Recovery in Transradial Amputees

Wang, Yingying; Peng, Fang; Tang, Xi; Jiang, Naifu; Lan, Tian; Li, Xiangxin; Zheng, Yue; Huang, Jianping; Samuel, Oluwarotimi Williams; Wang, Hui; Wu, Kai; Li, Guanglin

doi:10.1109/tnsre.2022.3155756

Cited by 15 publications

(8 citation statements)

References 34 publications

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“…Invasive techniques are based on the stimulation of nerves using implantable electrodes such as spiral cuffs 10 , Flat Interface Nerve Electrodes (FINEs) 11 , 12 , Transverse Intrafascicular Multichannel Electrodes (TIMEs) 13 or Utah Slanted Electrode Arrays (USEAs) 14 , or using epidural stimulation 15 . On the other hand, non-invasive techniques are based on the use of superficial electrodes positioned on the residual limb at the position of the main peripheral nerves (TENS) 16 – 18 . Whatever the kind of interface, electrical stimulation is typically performed using rectangular charge-balanced waveforms 19 .…”

Section: Introductionmentioning

confidence: 99%

Non-rectangular neurostimulation waveforms elicit varied sensation quality and perceptive fields on the hand

Collu

Earley

Barbaro

et al. 2023

Sci Rep

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Electrical stimulation of the nerves is known to elicit distinct sensations perceived in distal parts of the body. The stimulation is typically modulated in current with charge-balanced rectangular shapes that, although easily generated by stimulators available on the market, are not able to cover the entire range of somatosensory experiences from daily life. In this regard, we have investigated the effect of electrical neurostimulation with four non-rectangular waveforms in an experiment involving 11 healthy able-bodied subjects. Weiss curves were estimated and rheobase and chronaxie values were obtained showing increases in stimulation time required to elicit sensations for some waveforms. The localization of the sensations reported in the hand also appeared to differ between waveforms, although the total area did not vary significantly. Finally, the possibility of distinguishing different charge- and amplitude-matched stimuli was demonstrated through a two-alternative-forced-choice (2AFC) match-to-sample task, showing the ability of participants to successfully distinguish between waveforms with similar electrical characteristics but different shapes and charge transfer rates. This study provides evidence that, by using different waveforms to stimulate nerves, it is possible to affect not only the required charge to elicit sensations but also the sensation quality and its localization.

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Section: Introductionmentioning

confidence: 99%

Non-rectangular neurostimulation waveforms elicit varied sensation quality and perceptive fields on the hand

Collu

Earley

Barbaro

et al. 2023

Sci Rep

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“…Similar interesting phenomena have also been observed. Both the amplitude and latency of the maximum ERP peaks for the amputee were smaller than those for the able-bodied subjects ( Wang et al, 2022 ). One possible explanation is that the peripheral nerves regenerated in the stump were different from the intact one in structure and characteristics.…”

Section: Discussionmentioning

confidence: 71%

Substitutive proprioception feedback of a prosthetic wrist by electrotactile stimulation

Yichen

Yufeng

et al. 2023

Front. Neurosci.

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ObjectiveSensory feedback of upper-limb prostheses is widely desired and studied. As important components of proprioception, position, and movement feedback help users to control prostheses better. Among various feedback methods, electrotactile stimulation is a potential method for coding proprioceptive information of a prosthesis. This study was motivated by the need for proprioception information for a prosthetic wrist. The flexion-extension (FE) position and movement information of the prosthetic wrist are transmitted back to the human body through multichannel electrotactile stimulation.ApproachWe developed an electrotactile scheme to encode the FE position and movement of the prosthetic wrist and designed an integrated experimental platform. A preliminary experiment on the sensory threshold and discomfort threshold was performed. Then, two proprioceptive feedback experiments were performed: a position sense experiment (Exp 1) and a movement sense experiment (Exp 2). Each experiment included a learning session and a test session. The success rate (SR) and discrimination reaction time (DRT) were analyzed to evaluate the recognition effect. The acceptance of the electrotactile scheme was evaluated by a questionnaire.Main resultsOur results showed that the average position SRs of five able-bodied subjects, amputee 1, and amputee 2 were 83.78, 97.78, and 84.44%, respectively. The average movement SR, and the direction and range SR of wrist movement in five able-bodied subjects were 76.25, 96.67%, respectively. Amputee 1 and amputee 2 had movement SRs of 87.78 and 90.00% and direction and range SRs of 64.58 and 77.08%, respectively. The average DRT of five able-bodied subjects was less than 1.5 s and that of amputees was less than 3.5 s.ConclusionThe results indicate that after a short period of learning, the subjects can sense the position and movement of wrist FE. The proposed substitutive scheme has the potential for amputees to sense a prosthetic wrist, thus enhancing the human-machine interaction.

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“…Additionally, regular PHMs also make it easier to position the stimulus electrodes, a vital factor for successful sensation induction. Our previous studies also proved that the phantom fingers' sensations could only be successfully induced when TENS is applied to appropriate PHMs (Wang et al, 2022). However, the mechanism of PHM formation is still unclear, and the two most plausible theories, such as peripheral nerve regeneration of the stump and extensive cerebral reorganization after amputation, are not yet fully understood (Björkman et al, 2016;Strauss et al, 2019).…”

Section: Introductionmentioning

confidence: 94%

Electrical nerve stimulation for sensory-neural pathway reconstruction in upper-limb amputees

Wang

Liu²,

Zeng³

et al. 2023

Front. Neurosci.

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IntroductionThe loss of the neural sensory function pathways between the stump limbs and the brain greatly impacts the rehabilitation of limb function and the daily lives of amputees. Non-invasive physical stressors, such as mechanical pressure and transcutaneous electrical nerve stimulation (TENS), could be potential solutions for recovering somatic sensations in amputees. Previous studies have shown that stimulating the residual or regenerated nerves in the stumps of some amputees can produce phantom hand sensations. However, the results are inconclusive due to unstable physiological responses caused by inaccurate stimulus parameters and positions.MethodsIn this study, we developed an optimal TENS strategy by mapping the distribution of the nerves in the stump skin that elicitsphantom sensations known as a “phantom hand map.” We evaluated the effectiveness and stability of the confirmed stimulus configuration in a long-term experiment using single- and multi-stimulus paradigms. Additionally, we evaluated the evoked sensations by recording electroencephalograms (EEG) and analyzing brain activities.ResultsThe results demonstrated that various types of intuitive sensations for amputees could be stably induced by adjusting TENS frequencies, particularly at 5 and 50 Hz. At these frequencies, 100% stability of sensory types was achieved when the stimuli were applied to two specific locations on the stump skin. Furthermore, at these locations, the stability of sensory positions was 100% across different days. Moreover, the evoked sensations were objectively supported by specific patterns of event-related potentials in brain responses.DiscussionThis study provides an effective method for developing and evaluating physical stressor stimulus strategies, which could play an important role in the somatosensory rehabilitation of amputees and other patients suffering from somatomotor sensory dysfunction. The paradigm developed in this study can provide effective guidelines for stimulus parameters in physical and electrical nerve stimulation treatments for a variety of symptoms related to neurological disorders.

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Effective Evaluation of Finger Sensation Evoking by Non-Invasive Stimulation for Sensory Function Recovery in Transradial Amputees

Cited by 15 publications

References 34 publications

Non-rectangular neurostimulation waveforms elicit varied sensation quality and perceptive fields on the hand

Non-rectangular neurostimulation waveforms elicit varied sensation quality and perceptive fields on the hand

Substitutive proprioception feedback of a prosthetic wrist by electrotactile stimulation

Electrical nerve stimulation for sensory-neural pathway reconstruction in upper-limb amputees

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