Effective factors on iontophoretic transdermal delivery of memantine and donepezil as model drugs

Takmaz, Evrim Atilay; Yener, Gülgün

doi:10.1016/j.jddst.2021.102438

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…This is an important measure of quality for transdermal patches. [23]. The degree of the swelling property was determined by using the formula, Degree of swelling = Final weight − Initial weight Initial weight…”

Section: Swelling Indexmentioning

confidence: 99%

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Design, Development, and Evaluation of Transdermal Patches Containing Memantine Hydrochloride

VALEVETI,

PASHIKANTI

2023

Int J App Pharm

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Objective: This study aimed to develop an effective transdermal drug delivery system of memantine hydrochloride (MH), an anti-Alzheimer's drug, to improve patient compliance and optimize drug therapy in patients with dementia who often have difficulties adhering to oral medication schedules. Methods: Various transdermal patches of MH were prepared using the box-Behnken design of experiments with different polymer combinations. The fabricated patches were evaluated for properties like thickness, folding endurance, drug content uniformity, in vitro drug release, and diffusion studies. An optimal formulation was selected based on the results and further studied for pharmacokinetic parameters in rabbits. The results were compared to conventional tablets containing the same polymer combination. Results: Formulation B2 containing Hydroxy Propyl Methyl Cellulose (HPMC) 137.5 mg, Ethyl Cellulose (EC) 400 mg, and xanthan gum 300 mg had a flux of 212.24 μg/cm2/h, the permeability of 2.32 cm/h, and 27.95% release at 8h, with first-order and non-Fickian drug release kinetics. It was non-irritating, and in vitro release studies showed sustained release for up to 48 h. In vivo studies in rabbits also indicated superior drug absorption and sustained release from the patches compared to tablets. Conclusion: The optimized transdermal patch formulation had the potential to provide a prolonged release of MH for over 2 d and reduce the frequency of dosing. However, further studies are warranted to confirm the efficacy, safety, and pharmacokinetics of the patches in human models before clinical use.

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Section: Swelling Indexmentioning

confidence: 99%

“…The lower permeability of EC could be due to its tighter polymer chains, which allow for slower drug diffusion. Lower permeability can indicate slower drug release from a patch [23].…”

Section: Steady-state Fluxmentioning

confidence: 99%

Design, Development, and Evaluation of Transdermal Patches Containing Memantine Hydrochloride

VALEVETI,

PASHIKANTI

2023

Int J App Pharm

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“…An ideal surface pH close to the pH of the skin or neutral pH provides compatibility and tolerability. 21…”

Section: Surface Phmentioning

confidence: 99%

“…The weight increase of the patch was measured at regular intervals until the constant weight reached. 21 The degree of the swelling property was determined by using the formula, Drug content uniformity A 2 by 2 cm section was dissolved in 100 mL pH 7.4 buffer solution to measure the drug entrapped in the patch. The solution was shaken for 24 hours to completely dissolve the patch and then filtered.…”

Section: Swelling Indexmentioning

confidence: 99%

Design, Development, and Evaluation of Transdermal Patches Containing Donepezil Hydrochloride

SK,

2022

IJDDT

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This study aimed to develop a donepezil hydrochloride (DH) transdermal drug delivery system to address non-compliance due to dementia in Alzheimer’s patients. DH has a low dose, balanced hydrophilicity/lipophilicity, and low toxicity making it suitable for transdermal. DH transdermal patches were prepared using a polymer and plasticizer matrix system via box-Behnken design and evaluated for properties. Formulation B2 containing hydroxy propyl methyl cellulose (HPMC), ethyl cellulose (EC), and xanthan gum was optimal, exhibiting a maximum of ~99.17% in-vitro drug release for 48 hours. In-vivo pharmacokinetic parameters studied in rabbits were superior to commercial DH tablets. The study demonstrates the potential for DH transdermal patches as an alternative to oral medication for Alzheimer’s patients. The patches can provide sustained release for prolonged periods without requiring multiple doses. However, further confirmation is needed via in-vivo pharmacodynamic and human pharmacokinetic studies.

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Topical Drug Delivery Using Liposomes and Liquid Crystalline Phases for Skin Cancer Therapy

Nogueira¹,

Martins²,

Lima³

et al. 2023

Advances in Novel Formulations for Drug Delivery

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Effective factors on iontophoretic transdermal delivery of memantine and donepezil as model drugs

Cited by 5 publications

References 16 publications

Design, Development, and Evaluation of Transdermal Patches Containing Memantine Hydrochloride

Design, Development, and Evaluation of Transdermal Patches Containing Memantine Hydrochloride

Design, Development, and Evaluation of Transdermal Patches Containing Donepezil Hydrochloride

Topical Drug Delivery Using Liposomes and Liquid Crystalline Phases for Skin Cancer Therapy

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