“…The features include local statistics and texture modeling (Grim et al, 2009), wavelets (Rashed et al, 2007;Soltanian-Zadeha et al, 2004;Heinlein et al, 2003;Sentelle et al, 2002), and morphological features (Kallergi, 2004), and RIOs can be determined via segmentation followed by local thresholding, spatial filtering and active contours (Cheng et al, 2003;Hassanien, 2007; Cheng et al, 2004;. From the segmented ROIs, MCCs can be detected using heuristics (Sentelle et al, 2002), fuzzy sets (Hassanien, 2007;Cheng et al, 2004), sub-image decomposition and filtering (Nakayama et al, 2006), and machine learning algorithms such as decision tree, neural network and support vector machine Sajda et al, 2002;Bocchi et al, 2004), where shape features such as linear structure is widely used (Zwiggelaar et al, 2004;Nakayama et al, 2006;Ge et al, 2006;Wu et al, 2008).…”