In this paper, an error-detection-coding-aided iterative hard decision interference cancellation (EDC-IHIC) scheme for multiple-input multiple-output systems employing hybrid automatic repeat request (HARQ) for multi-packet transmission is developed and investigated. In the EDC-IHIC scheme, only packets identified as error-free by the EDC are submitted to the interference cancellation (IC) stage for cancellation from the received signals. Therefore, the possibility of error propagation, including inter-transmission error propagation, can be eliminated using EDC-IHIC. Because EDC must be implemented in systems that employ HARQ to determine packet retransmission, error propagation can be prevented without the need for additional redundancy. The results of simulations conducted herein verify that the EDC-IHIC scheme outperforms conventional hard decision IC schemes in terms of the packet error rate in various environments.