We examine the predictive capabilities of first-principles theoretical methods to calculate the phonon-and impurity-limited electron mobilities for a number of technologically relevant two-dimensional materials in comparison to experiment. The studied systems include perfect graphene, graphane, germanane and MoS 2 , as well as graphene with vacancies, and hydrogen, gold, and platinum adsorbates. We find good agreement with experiments for the mobilities of graphene (μ = 2 × 10 5 cm 2 V −1 s −1 ) and graphane (μ = 166 cm 2 V −1 s −1 ) at room temperature. For monolayer MoS 2 we obtain μ = 225 cm 2 V −1 s −1 . This value is higher than what is observed experimentally (0.5-200 cm 2 V −1 s −1 ) but is on the same order of magnitude as other recent theoretical results. For bulk MoS 2 we obtain μ = 48 cm 2 V −1 s −1 . We obtain a very high mobility of 18 200 cm 2 V −1 s −1 for single-layer germanane. The calculated reduction in mobility from the different impurities compares well to measurements where experimental data are available, demonstrating that the proposed method has good predictive capabilities and can be very useful for validation and materials design.