Effective Method To Remove Metal Elements from Pharmaceutical Intermediates with Polychelated Resin Scavenger

Abstract

A catalytic reaction is an important methodology for the production of pharmaceuticals from the viewpoint of green and sustainable chemistry. Since elemental impurity levels should be controlled within acceptable limits in API, the development of removal of element is also important as well. The technology for removal of elements was developed using cost-effective poly-chelated resin scavenger. The precious elements were removed efficiently by passing through the packed cartridge filled with appropriate scavenger. The feasibility of the scavenger was evaluated and the application for actual manufacturing process is described. In contrast to another type of immobilized scavengers, poly-chelated resin scavenger provides an inexpensive method to scavenge several elements.

Stereoselective oxidative glycosylation of anomeric nucleophiles with alcohols and carboxylic acids

“…The oxidative glycosylation is easy to conduct: all substrates are indefinitely stable, the reactions are performed at room temperature, and, due to the significant difference in polarity between the tin by-products and glycosides, purification by column chromatography on silica gel is straightforward and efficient. Furthermore, various technologies are available to remove trace amounts of tin and transition metals 46 , 47 .…”

Electrochemical ipso‐Thiocyanation of Arylboron Compounds

“…Cyanations of thiols, aryldisulfides, or thioethers are limited by starting‐material availability. Thiocyanations of arenediazonium salts or aryl halides are efficient, but rely on the heavy metal copper as a mediator . Only some electron‐deficient aromatic systems can also be thiocyanated by metal‐free substitutions of aryl halides…”

“…Thiocyanations of arenediazonium salts [10] or aryl halides [11] are efficient, but rely on the heavy metal copper as a mediator. [12] Only some electron-deficient aromatic systems can also be thiocyanated by metalfree substitutions of aryl halides. [13] Electrophilic aromatic thiocyanations are non-regiospecific and are traditionally performed with complex reagents, such as N-thiocyanatosuccinimide, or strong oxidants, e. g. Br 2 or K 2 S 2 O 8 , to generate the pseudohalogen (SCN) 2 from thiocyanate salts.…”

Functionalized Polyisobutylene and Liquid/Liquid Separations as a Method for Scavenging Transition Metals from Homogeneously Catalyzed Reactions

“…This issue has been addressed in a variety of ways [3,4], and the oldest approach is to use solid state sequestrants. There is an immense arsenal of ion exchange resins and functionalized inorganic supports that can sequester metals or metal catalyst residues [5][6][7][8][9][10][11]. These materials like ion exchange resins are insoluble and have the advantage that they are physically separable from product solutions.…”