Anisotropic superconducting properties including the upper critical field Hc2, thermal activation energy U0, and critical current density Jc are systematically studied in a large Ca1−xLaxFeAs2 single crystal (x ∼ 0.18). The obtained Hc2 bears a moderate anisotropy γ of approximately 2–4.2, located between those of “122” Ba1−xKxFe2As2 (1 < γ < 2) and “1111” NdFeAsO1−xFx (5 < γ < 9.2). Both the magnitude of U0 and its field dependence are very similar to those of NdFeAsO1−xFx, also indicating anisotropic superconductivity. Moreover, high and anisotropic Jc’s exceeding 105 A/cm2 have been calculated from the magnetization hysteresis loops, indicating the existence of strong bulk-dominated pinning in the present superconducting material.