Effective Prediction of Preeclampsia by a Combined Ratio of Angiogenesis-related Factors

Lim, Ji Hyae; Kim, S.Y.; Park, S.Y.; Yang, Jae‐Hun; Kim, M.Y.; Ryu, Hyun Mee

doi:10.1097/01.aoa.0000344695.90980.c0

Cited by 20 publications

(24 citation statements)

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“…Accuracy of fetal sex detection was determined with the final delivery record. Receiver operating characteristics (ROC) curve analysis was performed to assess the optimal cutoff value as in our previous study (26). The optimal cutoff was set at 100% specificity for each factor.…”

Section: Discussionmentioning

confidence: 99%

Effective detection of fetal sex using circulating fetal DNA in first‐trimester maternal plasma

Lim¹,

Park²,

Kim³

et al. 2011

FASEB j.

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The aim of this study was to develop a simple and effective method for noninvasively detecting fetal sex using circulating fetal DNA from first-trimester maternal plasma. A study was conducted with maternal plasma collected from 203 women between 5 and 12 wk of gestation. The presence of circulating fetal DNA was confirmed by a quantitative methylation-specific polymerase chain reaction of the unmethylated-PDE9A gene (U-PDE9A). Multiplex real-time PCR was used to simultaneously quantify the amount of DYS14 and GAPDH in maternal plasma. The results were confirmed by phenotype at birth. Pregnancy outcomes and U-PDE9A concentrations were obtained in all cases, including 99 male-bearing and 104 female-bearing participants. At equivalent specificity (100%), the false-negative rate was 9.1% for DYS14 quantification cycle, 7.1% for DYS14 concentration, and 0.0% for the concentration ratio of DYS14/GAPDH, respectively. In male-bearing participants, DYS14, U-PDE9A, and GAPDH concentrations were significantly lower in the false-negative case than in correct case (P<0.001 in all). Moreover, DYS14, U-PDE9A, and GAPDH concentrations showed significantly positive associations with each other (P≤0.001 in all). The ratio of DYS14/GAPDH in maternal plasma was an effective biomarker for noninvasive fetal sex detection during the first trimester, indicating that it could be useful for clinical application.

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Section: Discussionmentioning

confidence: 99%

Effective detection of fetal sex using circulating fetal DNA in first‐trimester maternal plasma

Lim¹,

Park²,

Kim³

et al. 2011

FASEB j.

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“…Several angiogenic or anti-angiogenic proteins, such as soluble fms-like tyrosine kinase 1 (sFlt-1), soluble endoglin (sEng), placental protein 13 (PP-13), pregnancy-associated plasma protein-A (PAPP-A), neutrophil gelatinase-associated lipocalin (NGAL), placental growth factor (PlGF), and vascular endothelial growth factor (VEGF), are known to be associated with PE [8][9][10][11][12][13][14], and changes in their abundance occur even before the onset of clinical disease [15]. However, none of these is currently regarded as a useful biomarker of PE.…”

Section: Introductionmentioning

confidence: 99%

Expression changes of proteins associated with the development of preeclampsia in maternal plasma: A case‐control study

et al. 2016

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Defective deep placentation, involving abnormal transformation of the spiral arteries in the junctional zone of the myometrium, is known to cause significant obstetric complications, such as preeclampsia (PE), fetal growth restriction, and placental infarction leading to fetal death. Serological biomarkers to predict and diagnose PE would help antenatal care and reduce obstetric complications. To discover candidate PE biomarkers, we first performed global proteomic profiling of three pairs of plasma samples obtained from pregnant women in the early second trimester, who subsequently developed PE, and controls to identify candidate proteins that were abundant in the patients. We further evaluated the changes in the expression of PE-representing proteins in stored plasma samples of a cohort that subsequently developed PE and their matched controls by MRM-MS analysis. We identified that both complement C1s subcomponent (C1S) and protein AMBP were elevated in the plasma samples of the PE cohort before the manifestation of clinical disease. We propose that these proteins may be involved in the remodeling process of the spiral arteries even before PE manifestation. These proteins can serve as potential plasma biomarkers to predict the pregnant women having an increased risk of developing PE.

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“…74,85 Una relación sFLt-1:PlGF alterada entre las 22 y 26 semanas de gestación, es altamente predictora de preeclampsia. 86 El principal marcador bioquímico estudiado como predictor de preeclampsia es el ultrasonido Doppler de la arteria uterina, cuyo hallazgo anormal (índice de pulsatibilidad elevado y/o presencia de notch) en primer y segundo trimestre ha demostrado su utilidad como prueba de escrutinio. 83,87 uso se basa en la hipótesis del papel del estrés oxidativo en la patogénesis de la preeclampsia.…”

Section: Predicción Y Prevención De Preeclampsiaunclassified

Construcción y validación de una escala de factores de riesgo para complicaciones de preeclampsia

Elizalde-Valdés

Téllez-Becerril

López-Aceves

2016

Clínica e Investigación en Ginecología y Obstetricia

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Effective Prediction of Preeclampsia by a Combined Ratio of Angiogenesis-related Factors

Cited by 20 publications

References 0 publications

Effective detection of fetal sex using circulating fetal DNA in first‐trimester maternal plasma

Effective detection of fetal sex using circulating fetal DNA in first‐trimester maternal plasma

Expression changes of proteins associated with the development of preeclampsia in maternal plasma: A case‐control study

Construcción y validación de una escala de factores de riesgo para complicaciones de preeclampsia

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