Effective Prevention and Management of Tumor Lysis Syndrome in Children With Cancer

Chung, Joanne Wai Yee; Tam, Ching Janice; Chiu, Sau Ying

doi:10.1177/1043454214555551

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…TLS occurs when tumour cells are destroyed and lysed due to chemotherapy or rapid, aggressive, and spontaneous lysis of proliferating tumour cells (Li et al, 2015). Tumour cells lyse and release various intracellular components, such as nucleic acids, which can develop into hyperuricemia and AKI (Edeani & Shirali, 2016;Aslan et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Paediatric patients have the highest percentage of TLS because they have an increased sensitivity to chemotherapy (Li et al, 2015). Cytotoxic-nephrotoxic chemotherapy can trigger tumour cell lysis such as methotrexate, vincristine, cytarabine, and daunorubicin (Arozal et al, 2010;Lameire, 2014;Sury, 2019;Bewersdorf & Zeiden, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Tumour lysis syndrome (TLS) is a critical oncological emergency (Li et al, 2015). It is found in children with 25% leukaemia and 23% lymphoma tumours of the central nervous system by 16.6% and 8-10% of neuroblastoma (Tazi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Allopurinol administration on the uric acid level and kidney function in paediatrics with tumour lysis syndrome (TLS) and high-risk TLS

Yulistiani,

Kharismawati,

Ugrasena

et al. 2023

Pharm Educ

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Background: Tumor lysis syndrome (TLS) is a life-threatening oncologic emergency because of the release of tumour cell components such as uric acid, which can lead to hyperuricemia and acute kidney injury (AKI). Objective: To analyse serum uric acid, creatinine, and BUN levels pre- and post-allopurinol administration. Method: This study was a prospective observational study conducted from March to July 2020. Inclusion criteria were haematological malignancies in paediatric patients with TLS and high-risk TLS who received allopurinol 10 mg/kg/day in 2-3 divided doses. Collected data were the serum uric acid, creatinine, and BUN levels pre- and post-allopurinol administration. Result: There were 14 sample in total during the study. There was a significant difference in uric acid level on day six after allopurinol administration compared to baseline in patients with high-risk TLS (p < 0.05). Conclusion: Allopurinol was inadequate in reducing uric acid levels in TLS patients but adequate in reducing uric acid levels in patients with high-risk TLS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of Allopurinol administration on the uric acid level and kidney function in paediatrics with tumour lysis syndrome (TLS) and high-risk TLS

Yulistiani,

Kharismawati,

Ugrasena

et al. 2023

Pharm Educ

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show abstract

“…TLS is commonly seen in patients with acute leukemia or Burkitt-type non-Hodgkin lymphomas (NHL), in whom tumor burden is high, cellular turnover is rapid, chemotherapeutic susceptibility is high and leukocyte counts are elevated. 2 Between 20 -50% of these cases eventually die unless TLS is appropriately diagnosed and treated. 3 The most commonly encountered neurological emergencies include spinal cord compression, convulsions, cerebrovascular accidents, increased intracranial pressure and improper intrathecal drug administrations.…”

mentioning

confidence: 99%

Evaluation of pediatric patients with an oncologic emergency: Single center experience

et al. 2018

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In this study, we aimed to prospectively analyze the emergency diagnosis and clinical characteristics of the oncologic emergency patients admitted, as well as to evaluate the approach considerations to the cases, their treatment, patient outcomes and the prognostic factors. A total of 88 oncologic emergency patients (90 oncologic emergency hospitalizations), except for febrile neutropenia, were admitted to the pediatric oncology department between July 2014 and December 2015. A total of 30 cases of tumor lysis syndrome, 19 hyperleukocytosis, 11 convulsion, 7 spinal cord compression, 7 hemorrhagic cystitis, 9 pleural effusion, 6 vena cava superior syndrome, 4 typhlitis, 3 anuria, 4 gastrointestinal bleeding, 3 hypercalcemia, 4 acute respiratory distress syndrome, 2 acute massive hepatomegaly and 1 increased intracranial pressure were identified. Sixty-five (72.2%) of the study patients had a primary oncologic disease, whereas 25 (27.8%) had a recurring condition. The most common presenting complaint was fever (23.3%) followed by breathing difficulties (22.2%). Fifty-nine patients (65.6%) recovered and were discharged home, while 31 cases (34.4%) died. Tumor lysis syndrome was the most frequently encountered emergency condition in the pediatric oncology patient group. Oncologic emergencies need to be approached quickly and systematically in the light of current scientific knowledge.

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Pediatric Oncology Nursing Research in Low- and Middle-Income Countries

et al. 2020

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Effective Prevention and Management of Tumor Lysis Syndrome in Children With Cancer

Cited by 5 publications

References 22 publications

Effect of Allopurinol administration on the uric acid level and kidney function in paediatrics with tumour lysis syndrome (TLS) and high-risk TLS

Effect of Allopurinol administration on the uric acid level and kidney function in paediatrics with tumour lysis syndrome (TLS) and high-risk TLS

Evaluation of pediatric patients with an oncologic emergency: Single center experience

Pediatric Oncology Nursing Research in Low- and Middle-Income Countries

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