This article describes a randomized evaluation of The Reading Edge, a reading program for middle-school students. The Reading Edge was designed to integrate findings of research on cooperative learning and metacognitive reading strategies into a replicable reading instructional package that could be implemented effectively in Title I middle schools. In this study, 788 sixth graders in two cohorts in two high-poverty, rural middle schools were randomly assigned to participate in The Reading Edge or to continue with their existing reading programs. Each cohort participated for one year. In both years, observations of classroom use of metacognitive strategies, cooperative learning, and goal setting/feedback showed moderate levels of implementation in The Reading Edge classes but little use in control classes. Statistically significant differences were found combining across cohorts on the Gates-MacGinitie reading test total (p < 0.01), comprehension (p < 0.05), and vocabulary (p < 0.01) scales. Effects were similar for students who were high, average, and low in pre-test scores. Outcomes for the two cohorts were nearly identical. These findings support a conclusion that effects of The Reading Edge are modest but reliable in high-poverty middle schools.