Effective removal of solar lentigines by combination of pre– And post–fluorescent light energy treatment with picosecond laser treatment

Scarcella, G.; Gerber, Peter Arne; Edge, Deirdre; Nielsen, Michael Engelbrecht

doi:10.1002/ccr3.2839

Cited by 6 publications

(10 citation statements)

References 17 publications

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“…Prior studies have demonstrated the efficacy and safety of picosecond lasers in solar lentigines treatment, both alone or in combination therapy. Scarcella et al showed the success of solar lentigines removal and enhanced rejuvenation at treated areas, when using the 532‐nm picosecond laser in combination with bio‐photonic treatment 28,29 . To the best of our knowledge, ours is the first study to compare the KTP 532‐nm and alexandrite 755‐nm picosecond lasers for removing solar lentigines in darker skin types.…”

Section: Discussionmentioning

confidence: 84%

“…Scarcella et al showed the success of solar lentigines removal and enhanced rejuvenation at treated areas, when using the 532-nm picosecond laser in combination with bio-photonic treatment. 28,29 To the best of our knowledge, ours is the first study to compare the KTP 532-nm and alexandrite 755-nm picosecond lasers for removing solar lentigines in darker skin types. A relatively large population of 30 subjects and a total of 60 lentigines were recruited.…”

Section: Discussionmentioning

confidence: 99%

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Randomized, evaluator‐blinded comparative study of a potassium titanyl phosphate (KTP) 532‐nm picosecond laser and an alexandrite 755‐nm picosecond laser for the treatment of solar lentigines in Asians

Vachiramon

Namasondhi

Anuntrangsee

et al. 2022

J of Cosmetic Dermatology

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Background: Various pigment-specific lasers can be used to treat solar lentigines.However, the most effective treatment options remain to be explored to reduce complications, such as postinflammatory hyperpigmentation, especially in dark-skinned patients.Objectives: This study aims to compare the efficacy and safety between the KTP 532nm picosecond laser and the alexandrite 755-nm picosecond laser for the treatment of solar lentigines in Asians. Materials and Methods:Thirty patients who had at least two solar lentigines on their arms were enrolled. A total of 30 paired lentiginous lesions were randomly selected for a single treatment with either a KTP 532-nm picosecond laser or an alexandrite 755-nm picosecond laser. Mean luminance score (L*) was evaluated at baseline and at 6 and 12 weeks to determine treatment efficacy. Improvement was assessed by a blinded physician using a 5-point score. Satisfaction was rated by patients using a visual analog scale. All adverse events were documented. Results:All 30 patients completed the study. Both lasers showed significant improvement in mean L* from baseline (p < 0.001). With the parameter settings employed, lesions treated with the alexandrite 755-nm picosecond laser showed greater improvement in mean L* when compared with treatment with the KTP 532-nm picosecond laser at 12 weeks follow-up (p = 0.002). According to physician scoring, more than 50% improvement was observed in 25 and 19 lesions of the alexandrite 755-nm picosecond laser group and the KTP 532-nm picosecond laser group, respectively. Adverse events did not differ between groups. A significantly higher satisfaction score was observed with the alexandrite 755-nm picosecond laser at the last visit (p = 0.038). Conclusion:Both types of picosecond laser may be used to treat solar lentigines.Proper treatment settings and endpoint observation are the most important factor to achieve a successful outcome.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Randomized, evaluator‐blinded comparative study of a potassium titanyl phosphate (KTP) 532‐nm picosecond laser and an alexandrite 755‐nm picosecond laser for the treatment of solar lentigines in Asians

Vachiramon

Namasondhi

Anuntrangsee

et al. 2022

J of Cosmetic Dermatology

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“…It is typically associated with older age and is located on body areas with high sun exposure, such as the face and hands. 5 …”

Section: Introductionmentioning

confidence: 99%

“…Current treatments may include topicals (eg, hydroquinone, retinoids, steroids), cryotherapy, chemical peels (eg, glycolic acid, salicylic acid), or laser therapy. 5 , 12 However, many of these treatments are associated with negative side effects. Hydroquinone has been found to be effective for PIH and solar lentigines but is relatively slow to work and can cause hypersensitivity and acneiform eruptions.…”

Section: Introductionmentioning

confidence: 99%

12-Week, Single-Center Study of a Targeted Pigment-Correcting Dark Spot Treatment for Post-Inflammatory Hyperpigmentation and Solar Lentigines

Makino,

Huang,

Cheng

et al. 2023

CCID

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Purpose Post-inflammatory hyperpigmentation (PIH) and solar lentigines are dark spots of skin from excessive melanin production due to injury or UV exposure. This 12-week single-center study assessed the efficacy and tolerability of a novel targeted pigment-correcting spot treatment gel suspension cream (Dark Spot Treatment) for improving mild-to-moderate PIH or solar lentigines. Patients and Methods Female participants (N = 41) aged 25–65 with mild-to-moderate facial dark spots applied Dark Spot Treatment daily for 12 weeks. Investigators assessed overall hyperpigmentation, skin tone evenness, and dark spot intensity, contrast, and size at Weeks 2, 4, 8, and 12. Participant self-assessments occurred at Weeks 1, 2, 4, 8, and 12. Tolerability was assessed by clinical grading and participant reporting. Results Dark Spot Treatment improved overall hyperpigmentation, skin tone evenness, and dark spot intensity and contrast at Weeks 2 through 12, and dark spot size at Weeks 4 through 12 (all p < 0.001 compared to baseline). Participant self-assessments showed high overall satisfaction. Dark Spot Treatment was well tolerated. Conclusion The novel pigment-correcting Dark Spot Treatment significantly improved the appearance of PIH and solar lentigines, had high participant satisfaction, and was well tolerated.

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“…Furthermore, FLE has been shown to significantly impact healthy [ 16 ], inflamed, and disease-affected skin tissues. The latter being well-documented in clinical trials and case studies, for acne [ 17 , 18 ], rosacea [ 19 , 20 ], acne conglobate and hidradenitis suppurativa [ 21 ], acneiforme eruption [ 22 ], senile lentigines [ 23 , 24 ], and wound healing [ 13 , 25 , 26 , 27 ]. Finally, a series of case studies investigating the effect of FLE treatment on healing of acute second-degree burns showed accelerated wound healing as well as overall improvement of tissue structure in two cases of severe HTS after burn injuries, suggesting that FLE balances wound healing at different stages of the wound healing and remodeling process [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Fluorescent light energy modulates healing in skin grafted mouse model

et al. 2021

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Skin grafting is often the only treatment for skin trauma when large areas of tissue are affected. This surgical intervention damages the deeper dermal layers of the skin with implications for wound healing and a risk of scar development. Photobiomodulation (PBM) therapy modulates biological processes in different tissues, with a positive effect on many cell types and pathways essential for wound healing. This study investigated the effect of fluorescent light energy (FLE) therapy, a novel type of PBM, on healing after skin grafting in a dermal fibrotic mouse model. Split-thickness human skin grafts were transplanted onto full-thickness excisional wounds on nude mice. Treated wounds were monitored, and excised xenografts were examined to assess healing and pathophysiological processes essential for developing chronic wounds or scarring. Results demonstrated that FLE treatment initially accelerated re-epithelialization and rete ridge formation, while later reduced neovascularization, collagen deposition, myofibroblast and mast cell accumulation, and connective tissue growth factor expression. While there was no visible difference in gross morphology, we found that FLE treatment promoted a balanced collagen remodeling. Collectively, these findings suggest that FLE has a conceivable effect at balancing healing after skin grafting, which reduces the risk of infections, chronic wound development, and fibrotic scarring.

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Effective removal of solar lentigines by combination of pre– And post–fluorescent light energy treatment with picosecond laser treatment

Abstract: We present a novel treatment for removal of SL that is efficient and enables removal or lesions not immediately visible. Kleresca® FLE technology combined with picosecond laser treatment removes SL lesions and improves skin quality and appearance.

Cited by 6 publications

References 17 publications

Randomized, evaluator‐blinded comparative study of a potassium titanyl phosphate (KTP) 532‐nm picosecond laser and an alexandrite 755‐nm picosecond laser for the treatment of solar lentigines in Asians

Randomized, evaluator‐blinded comparative study of a potassium titanyl phosphate (KTP) 532‐nm picosecond laser and an alexandrite 755‐nm picosecond laser for the treatment of solar lentigines in Asians

12-Week, Single-Center Study of a Targeted Pigment-Correcting Dark Spot Treatment for Post-Inflammatory Hyperpigmentation and Solar Lentigines

Fluorescent light energy modulates healing in skin grafted mouse model

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