Autonomous driving scenarios face the need for millisecond real-time response, which has led to the study of mobile networks with high speed and ultra-low latency. Software-defined networking (SDN) is recognized as a key technology for next-generation networks because it contains advanced functions such as centralized control, software-based traffic analysis, and forwarding rules for dynamic updates. In this paper, an SDN with flexible architecture is considered and a transport component is proposed. The component based on mesh topology is an example of joint route prediction and forwarding. First, different from existing transport protocols, the component can adopt a software-defined stream access control strategy that includes an extended forwarding mechanism (retransmission) to improve the shortterm response performance. Second, we evaluate the impact of route prediction on transport network performance by using offline training and prediction. The key challenge here is that a suitable model needs to be trained from a limited training sample dataset, which will dynamically update the forwarding rules based on current and historical facts (network data). By introducing a parallel neural network classifier, an intelligent route arrangement is implemented in this work. Experimental results over different traffic patterns verify the advantages of the design. Not only does it enhance the flexibility of SDN, but it also significantly reduces the signaling overhead of the transport network without reducing the network throughput.INDEX TERMS SDN, traffic control, routing, machine learning, prediction.