Effective Stereoselective Total Synthesis of 16,16-Dimethyl Prostaglandin E2

Resolvins D3 and E1 are important signaling molecules in the resolution of inflammation. Here, we report a convergent and flexible strategy to prepare these natural products using Hiyama–Denmark coupling of five- and six-membered cyclic alkenylsiloxanes to connect three resolvin fragments, and control the stereochemistry of the natural product (Z)-alkenes. The modular nature of this approach enables the synthesis of novel resolvin hybrids, opening up opportunities for more-extensive investigations of resolvin biology.

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Effective Stereoselective Total Synthesis of 16,16-Dimethyl Prostaglandin E2

Cited by 3 publications

References 17 publications

ChemInform Abstract: Effective Stereoselective Total Synthesis of 16,16‐Dimethyl Prostaglandin E₂.

ChemInform Abstract: Effective Stereoselective Total Synthesis of 16,16‐Dimethyl Prostaglandin E₂.

Total synthesis of E1 and E2 isoprostanes by diastereoselective protonation

A Modular, Enantioselective Synthesis of Resolvins D3, E1, and Hybrids

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Effective Stereoselective Total Synthesis of 16,16-Dimethyl Prostaglandin E2

Cited by 3 publications

References 17 publications

ChemInform Abstract: Effective Stereoselective Total Synthesis of 16,16‐Dimethyl Prostaglandin E2.

ChemInform Abstract: Effective Stereoselective Total Synthesis of 16,16‐Dimethyl Prostaglandin E2.

Total synthesis of E1 and E2 isoprostanes by diastereoselective protonation

A Modular, Enantioselective Synthesis of Resolvins D3, E1, and Hybrids

Contact Info

Product

Resources

About

ChemInform Abstract: Effective Stereoselective Total Synthesis of 16,16‐Dimethyl Prostaglandin E₂.

ChemInform Abstract: Effective Stereoselective Total Synthesis of 16,16‐Dimethyl Prostaglandin E₂.