Effective suppression of concentration polarization by nanofiltration membrane surface pattern manipulation: Numerical modeling based on LIF visualization

Shang, Wentao; Li, Xiaoyan; Liu, Wenjie; Yue, Sanfeng; Eiff, David von; Sun, Feiyun; An, Alicia Kyoungjin

doi:10.1016/j.memsci.2020.119021

Cited by 26 publications

(18 citation statements)

References 59 publications

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“…However, no membrane is perfectly flat, and therefore experiments need to be conducted to validate these models. Interestingly, Shang et al recently reported using CFD models that predicted 100 µm triangular and cambered micro-patterned membranes would decrease concentration polarization [40]. These differing models provided motivation for this study to gain experimental results to compare to these computational studies.…”

Section: Introductionmentioning

confidence: 96%

“…Membrane surface patterning has been studied extensively to reduce fouling [9,10,[30][31][32][33][34][35][36][37][38]. Other studies have investigated the use of patterns to control the wetting of surfaces and membranes [30,40,41]. ElSherbiny et al showed that 10-20 µm line-and-groove patterns connected by branches caused a slight decrease in concentration polarization on RO membranes [37].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Nanopatterning on Concentration Polarization during Nanofiltration

Ward¹,

Fickling²,

Weinman³

2021

Membranes

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Membranes used for desalination still face challenges during operation. One of these challenges is the buildup of salt ions at the membrane surface. This is known as concentration polarization, and it has a negative effect on membrane water permeance and salt rejection. In an attempt to decrease concentration polarization, a line-and-groove nanopattern was applied to a nanofiltration (NF) membrane. Aqueous sodium sulfate (Na2SO4) solutions were used to test the rejection and permeance of both pristine and patterned membranes. It was found that the nanopatterns did not reduce but increased the concentration polarization at the membrane surface. Based on these studies, different pattern shapes and sizes should be investigated to gain a fundamental understanding of the influence of pattern size and shape on concentration polarization.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Effect of Nanopatterning on Concentration Polarization during Nanofiltration

Ward¹,

Fickling²,

Weinman³

2021

Membranes

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“…Membrane filtration relies on the mesh size of the hydrogel and can be influenced by some factors including solute concentration and temperature. 42,44 The mesh size of hydrogel depends on many factors, such as crosslinker and polymer concentrations and stimulus. 44 The influence of DNA concentration in the hydrogel was first investigated.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…35−39 Besides, hydrogels are porous three-dimensional (3D) networks filled with aqueous media, which are capable of encapsulating macromolecules 40,41 and separation process. 42 Conventional detection methods based on DNA hydrogel rely on target-induced crosslinker disruption, resulting in gel-to-sol transition and release of encapsulated species. However, most of the reported methods are carried out by encapsulating cargoes in the hydrogel, 40,41 and few reports are used for the detection of biological macromolecules.…”

mentioning

confidence: 99%

“…Recently, because the inclusion of an analyte-responsive DNA crosslinker allows for gel transition in response to various stimuli including pH, metal ions, and molecules, , intelligent DNA hydrogel has attracted a lot of attention for sensing, biomimetics, intelligent drug delivery, and biomedical engineering. − Besides, hydrogels are porous three-dimensional (3D) networks filled with aqueous media, which are capable of encapsulating macromolecules , and separation process . Conventional detection methods based on DNA hydrogel rely on target-induced crosslinker disruption, resulting in gel-to-sol transition and release of encapsulated species.…”

mentioning

confidence: 99%

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Distance-Based Biosensor for Ultrasensitive Detection of Uracil-DNA Glycosylase Using Membrane Filtration of DNA Hydrogel

et al. 2021

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In the deoxyribonucleic acid (DNA) repair pathways, DNA repair enzymes have great significance for genomic integrity. As one important initiator of the base-excision repair pathway, the aberrant activity of uracil-DNA glycosylase (UDG) is closely associated with many diseases. Herein, we developed a simple distance-based device for visual detection of UDG activity using a load-free DNA hydrogel. The DNA hydrogel consists of polyacrylamide–DNA chains being bridged by a single-stranded DNA crosslinker containing a responsive uracil base site. UDG can recognize and remove the uracil, resulting in the cleavage effect of the DNA crosslinker strand with the assistance of endonuclease IV (Endo IV). Plugging one end of the capillary tube, the DNA hydrogel acting as a filter membrane separator would control molecules to flow into the tube. The integrity of the DNA hydrogel networks is affected by the excision of UDG. Therefore, taking full advantage of membrane filtration of the DNA hydrogel, the activity of UDG can be quantitatively detected via reading the distance of the red indicator solution in the capillary tube. Without any instruments and complicated procedures, this method realizes high sensitivity and specificity for the detection of UDG as low as 0.02 mU/mL and can even measure UDG in complex cell samples. Additionally, this method is simple, universal, and can be used to screen inhibitors, which shows great potential for point-of-care testing, clinical diagnosis, and drug discovery.

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