2024
DOI: 10.3390/molecules29194713
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Effective Synthesis of mRNA during In Vitro Transcription with Fewer Impurities Produced

Wei He,
Qi Geng,
Guiying Ji
et al.

Abstract: The remarkable efficacy of COVID-19 vaccines has established mRNA as a highly promising biomedical technology. However, the adequate application of mRNA therapeutics necessitates additional measures to mitigate the inherent immunogenicity, which is predominantly caused by dsRNA. As a byproduct of the in vitro transcription of mRNA, dsRNA was reported to be originated through several distinct mechanisms, including the extension of 3′ loop-back hairpins, the extension of hybridized abortive transcripts, and prom… Show more

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