Effective Thermal Penetration Depth in Photo-Irradiated Ex Vivo Human Tissues

Stolik, S.; Delgado, José A.; Anasagasti, L.; Olivares‐Pérez, A.

doi:10.1089/pho.2010.2948

Cited by 9 publications

(6 citation statements)

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“…While the optical scattering regulates the light propagation direction and can be ascribed to the interaction of the photons with cellular and subcellular structures, light absorption entails a localized temperature increase due to the presence of specific tissue chromophores 16 . Penetration depth is the measure of how deeply light can penetrate the medium and depends on the tissue scattering and absorption properties, whose combined effect leads to the effective transport coefficient, which ultimately rules light attenuation for a highly scattering medium 17 .…”

Section: Introductionmentioning

confidence: 99%

Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies

Lanka

Bianchi

Farina

et al. 2022

Sci Rep

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This work reports the optical properties of porcine pancreatic tissue in the broad wavelength range of 600–1100 nm. Absorption and reduced scattering coefficients (µa and µs′) of the ex vivo pancreas were obtained by means of Time-domain Diffuse Optical Spectroscopy. We have investigated different experimental conditions—including compression, repositioning, spatial sampling, temporal stability—the effect of the freezing procedure (fresh vs frozen-thawed pancreas), and finally inter-sample variability. Good repeatability under different experimental conditions was obtained (median coefficient of variation less than 8% and ~ 16% for µa and µs′, respectively). Freezing–thawing the samples caused an irreversible threefold reduction of µs′ and no effect on µa. The absorption and reduced scattering spectra averaged over different samples were in the range of 0.12–0.74 cm−1 and 12–21 cm−1 with an inter-sample variation of ~ 10% and ~ 40% for µa and µs′, respectively. The calculated effective transport coefficient (µeff) for fresh pancreatic tissue shows that regions between 800–900 nm and 1050–1100 nm are similar and offer the lowest tissue attenuation in the considered range (i.e., µeff ranging from 2.4 to 2.7 cm−1). These data, describing specific light-pancreas interactions in the therapeutic optical window for the first time, provide pivotal information for planning of light-based thermotherapies (e.g., laser ablation) and instruction of light transport models for biophotonic applications involving this organ.

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Section: Introductionmentioning

confidence: 99%

Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies

Lanka

Bianchi

Farina

et al. 2022

Sci Rep

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“…After selecting a suitable thermosensitive nanocarrier, noninvasive hyperthermia should also be considered carefully. Although near-infrared (NIR)-mediated photothermal treatment has been employed widely in this field, its drawbacks with respect to depth-limitation restrict its application in clinical studies (Stolik et al, 2000). Compared to photothermal treatment, superparamagnetic nanoparticleinduced magnetic hyperthermia (MH) has more potential for tumor treatment because of the high penetration of alternative magnetic field (AMF) in the human body.…”

Section: Introductionmentioning

confidence: 99%

“…As reported in previous studies (Stolik et al, 2000;Manzoor et al, 2012;Li et al, 2013;Qu et al, 2014b;Mo et al, 2019;Qu et al, 2022), we designed magnetothermally sensitive micelles (MTMs), which integrate MT and MH into one versatile drug delivery system to enhance simultaneous drug accumulation and drug penetration in the tumor (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Enhanced tumor penetration for efficient chemotherapy by a magnetothermally sensitive micelle combined with magnetic targeting and magnetic hyperthermia

Wang

Wang²,

Chen³

et al. 2022

Front. Pharmacol.

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The high accumulation and poor penetration of nanocarriers in tumor is a contradiction of nanomedicine, which reduces the efficacy of chemotherapy. Due to the positive effect of hyperthermia on in vivo drug diffusion, we designed a magnetothermally sensitive micelle (MTM) by integrating magnetic targeting (MT), magnetic hyperthermia (MH), and magnetothermally responsive drug release to facilitate simultaneous drug accumulation and penetration in tumor. Accordingly, we synthesized a cyanine7-modified thermosensitive polymer with phase transition at 42.3°C, and utilized it to prepare drug-loaded MTMs by encapsulating superparamagnetic MnFe2O4 nanoparticles and doxorubicin (DOX). The obtained DOX–MTM had not only high contents of DOX (9.1%) and MnFe2O4 (38.7%), but also some advantages such as superparamagnetism, high saturation magnetization, excellent magnetocaloric effect, and magnetothermal-dependent drug release. Therefore, DOX–MTM improved in vitro DOX cytotoxicity by enhancing DOX endocytosis under the assistance of MH. Furthermore, MT and MH enhanced in vivo DOX–MTM accumulation and DOX penetration in tumor, respectively, substantially inhibiting tumor growth (84%) with excellent biosafety. These results indicate the development of an optimized drug delivery system with MH and MH-dependent drug release, introducing a feasible strategy to enhance the application of nanomedicines in tumor chemotherapy.

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“…Independentemente do sítio de absorção, esta energia é absorvida pelos cromóforos* intracelulares e convertida em energia metabólica (ver apêndice). STOLIK et al, 2011).…”

Section: Efeitos Do Laser Em Baixa Intensidade Na Estimulação Daunclassified

“…Respaldados na literatura, adotamos um comprimento de onda na faixa do infravermelho, que é o mais apropriado para que se possa atingir o tecido ósseo (WAN;PARRISH, 1981;KOLA´ROVA´;DITRICHOVA´;WAGNER, 1999;FRANZEN, 2004;LIZARELLI, 2007;SOUSA et al, 2011;STOLIK et al, 2011). Observe no quadro 1, transcrito parcialmente, que todos os autores utilizaram o comprimento de onda na faixa do infravermelho (CRUZ et al, 2004;LIMPANICHKUL et al, 2006;YOUSSEF, et al, 2008;CAMACHO;CUJAR, 2010;SOUSA et al, 2011;DOSHI-MEHTA;BHAD-PATIL, 2012;GENC, et al, 2012).…”

Section: Dosimetriaunclassified

Avaliação da influência do laser de baixa intensidade como recurso de ancoragem ortodôntica e na supressão da dor

Sousa¹

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Aos meus filhos Aos meus filhos Aos meus filhos Aos meus filhos Bárbara e Bruno Bárbara e Bruno Bárbara e Bruno Bárbara e Bruno Há momentos que nem as mais belas palavras podem transmitir o intenso e forte sentimento, e para esses momentos cabe o olhar... Olhando para vocês tenho a convicção de que o melhor e maior projeto de toda a minha vida, sem dúvida nenhuma, foi tê-los como filhos, fazendo parte da minha vida. Agradeço a vocês pela paciência e pelo tempo roubado. O tempo roubado não se consegue de volta, mas o tempo presente é possível fazer valer à pena. Amo vocês! "A vida não se mede pelo tempo que durou e sim por momentos especiais que se eternizou".

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Effective Thermal Penetration Depth in Photo-Irradiated Ex Vivo Human Tissues

Abstract: The effective thermal penetration depth has been defined, and this could be useful for developing models to describe the thermal effects with a separate analysis of the tissue itself and the blood that irrigates it.

Cited by 9 publications

References 44 publications

Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies

Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies

Enhanced tumor penetration for efficient chemotherapy by a magnetothermally sensitive micelle combined with magnetic targeting and magnetic hyperthermia

Avaliação da influência do laser de baixa intensidade como recurso de ancoragem ortodôntica e na supressão da dor

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